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Per-pass analysis o...
Per-pass analysis of acute ischemic stroke clots: impact of stroke etiology on extracted clot area and histological composition.
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Fitzgerald, Seán (author)
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Rossi, Rosanna (author)
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Mereuta, Oana Madalina (author)
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Jabrah, Duaa (author)
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Okolo, Adaobi (author)
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Douglas, Andrew (author)
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Molina Gil, Sara (author)
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Pandit, Abhay (author)
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McCarthy, Ray (author)
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Gilvarry, Michael (author)
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- Dunker, Dennis (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för radiologi,Institute of Clinical Sciences, Department of Radiology
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- Nordanstig, Annika, 1974 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
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- Ceder, Erik (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för radiologi,Institute of Clinical Sciences, Department of Radiology
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- Redfors, Petra (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
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- Jood, Katarina, 1966 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
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- Dehlfors, Niclas (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för radiologi,Institute of Clinical Sciences, Department of Radiology
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Magoufis, Georgios (author)
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Tsivgoulis, Georgios (author)
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Brinjikji, Waleed (author)
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Kallmes, David F (author)
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O'Hare, Alan (author)
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Power, Sarah (author)
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Brennan, Paul (author)
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Alderson, Jack (author)
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Nagy, András (author)
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Vadász, Ágnes (author)
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Psychogios, Klearchos (author)
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Szikora, Istvan (author)
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- Tatlisumak, Turgut (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
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- Rentzos, Alexandros, 1979 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för radiologi,Institute of Clinical Sciences, Department of Radiology
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Thornton, John (author)
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Doyle, Karen M (author)
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(creator_code:org_t)
- 2020-12-09
- 2021
- English.
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In: Journal of neurointerventional surgery. - : BMJ. - 1759-8486 .- 1759-8478. ; 13, s. 1111-1116
- Related links:
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https://jnis.bmj.com...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Initial studies investigating correlations between stroke etiology and clot composition are conflicting and do not account for clot size as determined by area. Radiological studies have shown that cardioembolic strokes are associated with shorter clot lengths and lower clot burden than non-cardioembolic clots.To report the relationship between stroke etiology, extracted clot area, and histological composition at each procedural pass.As part of the multi-institutional RESTORE Registry, the Martius Scarlett Blue stained histological composition and extracted clot area of 612 per-pass clots retrieved from 441 patients during mechanical thrombectomy procedures were quantified. Correlations with clinical and procedural details were investigated.Clot composition varied significantly with procedural passes; clots retrieved in earlier passes had higher red blood cell content (H4=11.644, p=0.020) and larger extracted clot area (H4=10.730, p=0.030). Later passes were associated with significantly higher fibrin (H4=12.935, p=0.012) and platelets/other (H4=15.977, p=0.003) content and smaller extracted clot area. Large artery atherosclerotic (LAA) clots were significantly larger in the extracted clot area and more red blood cell-rich than other etiologies in passes 1-3. Cardioembolic and cryptogenic clots had similar histological composition and extracted clot area across all procedural passes.LAA clots are larger and associated with a large red blood cell-rich extracted clot area, suggesting soft thrombus material. Cardioembolic clots are smaller in the extracted clot area, consistent in composition and area across passes, and have higher fibrin and platelets/other content than LAA clots, making them stiffer clots. The per-pass histological composition and extracted clot area of cryptogenic clots are similar to those of cardioembolic clots, suggesting similar formation mechanisms.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Fitzgerald, Seán
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Rossi, Rosanna
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Mereuta, Oana Ma ...
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Jabrah, Duaa
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Okolo, Adaobi
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Douglas, Andrew
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show more...
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Molina Gil, Sara
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Pandit, Abhay
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McCarthy, Ray
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Gilvarry, Michae ...
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Dunker, Dennis
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Nordanstig, Anni ...
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Ceder, Erik
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Redfors, Petra
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Jood, Katarina, ...
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Dehlfors, Niclas
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Magoufis, Georgi ...
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Tsivgoulis, Geor ...
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Brinjikji, Walee ...
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Kallmes, David F
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O'Hare, Alan
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Power, Sarah
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Brennan, Paul
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Alderson, Jack
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Nagy, András
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Vadász, Ágnes
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Psychogios, Klea ...
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Szikora, Istvan
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Tatlisumak, Turg ...
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Rentzos, Alexand ...
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Thornton, John
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Doyle, Karen M
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Radiology Nuclea ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Journal of neuro ...
- By the university
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University of Gothenburg