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Quick Systemic Lupu...
Quick Systemic Lupus Activity Questionnaire (Q-SLAQ): a simplified version of SLAQ for patient-reported disease activity
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- Svenungsson, E. (författare)
- Karolinska Institutet,Karolinska University Hospital,Karolinska Inst, Dept Med Solna, Div Rheumatol, Stockholm, Sweden.;Karolinska Univ Hosp, Rheumatol, Stockholm, Sweden.
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- Gunnarsson, I. (författare)
- Karolinska Institutet,Karolinska University Hospital,Karolinska Inst, Dept Med Solna, Div Rheumatol, Stockholm, Sweden.;Karolinska Univ Hosp, Rheumatol, Stockholm, Sweden.
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- Illescas-Backelin, V. (författare)
- Karolinska Institutet,Karolinska Inst, Dept Med Solna, Div Rheumatol, Stockholm, Sweden.
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- Trysberg, Estelle, 1960 (författare)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Univ Gothenburg, Dept Rheumatol & Inflammat Res, Gothenburg, Sweden.
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- Jönsen, Andreas (författare)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund SLE Research Group,Forskargrupper vid Lunds universitet,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,Lund Univ, Dept Clin Sci Lund, Rheumatol, Lund, Sweden.
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- Leonard, Dag, 1975- (författare)
- Uppsala universitet,Uppsala University,Reumatologi,Science for Life Laboratory, SciLifeLab,Uppsala Univ, Sweden
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- Sjöwall, Christopher (författare)
- Linköpings universitet,Linköping University,Linköping Univ, Div Inflammat & Infect Rheumatol, Dept Biomed & Clin Sci, Linköping, Sweden.,Avdelningen för inflammation och infektion,Medicinska fakulteten,Region Östergötland, Reumatologiska kliniken i Östergötland
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- Pettersson, S. (författare)
- Karolinska Institutet,Karolinska University Hospital,Karolinska Univ Hosp, Rheumatol, Stockholm, Sweden.;Karolinska Inst, Div Physiotherapy, Dept Neurobiol Care Sci & Soc, Stockholm, Sweden.
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(creator_code:org_t)
- 2021-05-10
- 2021
- Engelska.
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Ingår i: Lupus Science & Medicine. - : BMJ. - 2053-8790. ; 8
- Relaterad länk:
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https://lupus.bmj.co...
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http://dx.doi.org/10... (free)
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://liu.diva-por... (primary) (Raw object)
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Objectives Most indices of disease activity in SLE combine physicians' assessments and laboratory tests. However, there is also a need to capture patients' perspectives of disease activity. Consequently, we need new, preferably quick and easy instruments to collect this information, which can be very useful for online consultations and registry purposes. We compared patients' assessments of SLE disease impact/activity, as reported by a shorter version of the Quick Systemic Lupus Activity Questionnaire (Q-SLAQ), with physicians' assessments using SLE Activity Measure (SLAM) and SLE Disease Activity Index (SLEDAI-2K) and with the original Systemic Lupus Activity Questionnaire (SLAQ). Methods Patients with SLE (n=115), with a disease duration of 15 years (IQR 17), completed the Q-SLAQ prior to physicians' assessments by SLAM and SLEDAI-2K. A second set of patients (n=85) with similar characteristics filled out Q-SLAQ and SLAQ. Spearman's rho correlations were explored between patients' total Q-SLAQ and subscales (Symptom Score, Patient's Global Disease Activity) and physicians' SLAM and SLEDAI-2K, with and without laboratory items (SLAM-nolab and SLEDAI-2K-nolab) and SLAQ. Corresponding items in Q-SLAQ and SLAM were compared. Results Correlations between patients' and physicians' assessments were higher for SLAM-nolab (total Q-SLAQ, rho=0.71; Symptom Score, rho=0.67; and Patient's Global Disease Activity, rho=0.68) than for the original SLAM (total Q-SLAQ, rho=0.53; Symptom Score, rho=0.50; and Patient's Global Disease Activity, rho=0.53). Regarding specific symptoms, fatigue (rho=0.72) and alopecia (rho=0.71) correlated best, while pulmonary/respiratory symptoms correlated least (rho=0.19, p=0.039). Physicians assessment with SLEDAI-2K-nolab correlated weakly with patients' assessments (total Q-SLAQ, rho=0.30; Symptom Score, rho=0.30; and Patient's Global Disease Activity, rho=0.36). Bivariate correlations between Q-SLAQ and SLAQ were good (rho=0.82-0.96). Conclusions Q-SLAQ and the original SLAQ performed equally well, demonstrating that the shorter Q-SLAQ can safely be used to monitor patients' perception of disease impact/activity. We also noted an intriguing discrepancy between physicians' and patients' evaluations of pulmonary/respiratory symptoms, which requires further investigations.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Nyckelord
- lupus erythematosus
- systemic
- outcome assessment
- health care
- autoimmune diseases
- activity index
- erythematosus
- validation
- responsiveness
- assessments
- discordance
- validity
- criteria
- burden
- Rheumatology
- lupus erythematosus
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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