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Long-Term Prognosti...
Long-Term Prognostication for 20 114 Women With Small and Node-Negative Breast Cancer (T1abN0)
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- Jaraj, D. (författare)
- Clinical Epidemiology Division, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden; Department of Surgery, Capio St Görans Hospital, Stockholm, Sweden
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- Hoijer, J. (författare)
- Unit of Biostatistics, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
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- Widman, L. (författare)
- Karolinska Institutet
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- Ahlgren, J. (författare)
- Department of Oncology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden; Regional Cancer Centre, Uppsala Örebro Health Care Region, Uppsala, Sweden
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- Arnesson, Lars-Gunnar (författare)
- Linköpings universitet,Institutionen för biomedicinska och kliniska vetenskaper,Medicinska fakulteten,Region Östergötland, Kirurgiska kliniken US
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- Einbeigi, Zakaria, 1962 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Institute of Clinical Sciences, Department of Oncology,Department of Medicine, Southern Älvsborg Hospital, Borås, Sweden; Department of Oncology, Institute of Clinical Sciences, Sahlgrenska Academy, Sahlgrenska University Hospital, Gothenburg, Sweden
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- Klintman, M. (författare)
- Department of Oncology and Radiation Physics, Skåne University Hospital, Lund University, Lund, Sweden
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- Vikhe Patil, Eva (författare)
- Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Kirurgiska kliniken US
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- Sund, Malin (författare)
- Umeå universitet,Kirurgi,Department of Surgical and Perioperative Sciences/Surgery, Umeå University, Umeå, Sweden
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- Fredriksson, I. (författare)
- Karolinska Institutet
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- Bergh, J. (författare)
- Karolinska Institutet
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- Andreas, P. (författare)
- Clinical Epidemiology Division, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden
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(creator_code:org_t)
- 2020-09-26
- 2021
- Engelska.
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Ingår i: Jnci Cancer Spectrum. - : Oxford University Press (OUP). - 2515-5091. ; 5:1
- Relaterad länk:
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https://academic.oup...
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://liu.diva-por... (primary) (Raw object)
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background: Although small, node-negative breast cancer (ie, T1abN0) constitutes 20% of all newly diagnosed breast cancers, data on prognosis and prognostic factors are limited. Methods: We conducted a population-based cohort study including 20 114 Swedish women treated for T1abN0 breast cancer from 1977 onward. Patient and tumor data were collected from Swedish breast cancer registries. Cohort subjects were followed through linkage to the Cause of Death Register. We calculated the cumulative incidence of breast cancer-specific and overall death and used Cox regression to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). Results: During a median follow-up of 9.1 years (range = 0-38), 915 women died of breast cancer and 5416 of any cause. The 10-, 20-, and 30-year cumulative incidences of breast cancer death were 3.4% (95% CI = 3.1% to 3.7%), 7.6% (95% CI = 7.1% to 8.2%), and 10.5% (95% CI = 9.6% to 11.4%), respectively. The multivariable hazard ratios and 95% confidence intervals of breast cancer death were 0.92 (95% CI = 0.88 to 0.97) for each additional calendar year of diagnosis, 4.38 (95% CI = 2.79 to 6.87) for grade 3 vs grade 1 tumors, 0.43 (95% CI = 0.31 to 0.62) for progesterone receptor-positive vs progesterone receptor-negative disease, and 2.01 (95% CI = 0.99 to 4.07) for HER2-positive vs HER2-negative disease. Women with grade 3 vs grade 1 tumors had a 56% increased risk of death from any cause (HR = 1.56, 95% CI = 1.30 to 1.88). Conclusions: The risk of breast cancer death in T1abN0 disease continues to increase steadily beyond 10 years after diagnosis, has improved over time, and varies substantially by tumor characteristics.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Nyckelord
- population
- validation
- recurrence
- prognosis
- mortality
- carcinoma
- outcomes
- trials
- death
- size
- Oncology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Jaraj, D.
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Hoijer, J.
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Widman, L.
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Ahlgren, J.
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Arnesson, Lars-G ...
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Einbeigi, Zakari ...
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visa fler...
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Klintman, M.
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Vikhe Patil, Eva
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Sund, Malin
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Fredriksson, I.
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Bergh, J.
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Andreas, P.
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kirurgi
- Artiklar i publikationen
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Jnci Cancer Spec ...
- Av lärosätet
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Göteborgs universitet
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Umeå universitet
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Linköpings universitet
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Karolinska Institutet