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  • Bengtsson, DanielLinköpings universitet,Linköping University,Kalmar County Hospital,Dept Internal Med, Halsogrand 2, S-39185 Kalmar, Sweden.;Linköping Univ, Dept Biomed & Clin Sci, Linköping, Sweden.,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Department of Internal Medicine, Kalmar, Region of Kalmar County , Kalmar, Sweden (author)

Psychotropic Drugs in Patients with Cushing's Disease Before Diagnosis and at Long-Term Follow-Up: A Nationwide Study

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • 2021-02-10
  • The Endocrine Society,2021

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/306068
  • https://gup.ub.gu.se/publication/306068URI
  • https://doi.org/10.1210/clinem/dgab079DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-89505URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-180269URI
  • https://lup.lub.lu.se/record/b5b76a88-1431-4900-a2b6-b61c3465cd1cURI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-447921URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-174801URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:146783170URI

Supplementary language notes

  • Language:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agencies:Medical Research Council of Southeast SwedenSwedish state under the agreement between the Swedish government and the county councilsALF-agreement ALFGBG-771841 936463Skåne University Hospital
  • Funding: Medical Research Council of Southeast SwedenUK Research & Innovation (UKRI)Medical Research Council UK (MRC); Swedish government; county councils; ALF [ALFGBG-771841, ALFGBG-936463]; Skane University Hospital
  • Context: Psychiatric symptoms are common in Cushing's disease (CD) and seem only partly reversible following treatment. Objective: To investigate drug dispenses associated to psychiatric morbidity in CD patients before treatment and during long-term follow-up. Design: Nationwide longitudinal register-based study. Setting: University Hospitals in Sweden. Subjects: CD patients diagnosed between 1990 and 2018 (N = 372) were identified in the Swedish Pituitary Register. Longitudinal data was collected from 5 years before, at diagnosis, and during follow-up. Four matched controls per patient were included. Cross-sectional subgroup analysis of 76 patients in sustained remission was also performed. Main outcome measures: Data from the Swedish Prescribed Drug Register and the Patient Register. Results: In the 5-year period before and at diagnosis, use of antidepressants (odds ratio [OR] 2.2 [95% confidence interval (CI) 1.3-3.7]) and 2.3 [1.6-3.5]), anxiolytics [2.9 (1.6-5.3) and 3.9 (2.3-6.6)], and sleeping pills [2.1 (1.2-3.7) and 3.8 (2.4-5.9)] was more common in CD than controls. ORs remained elevated at 5-year follow-up for antidepressants [2.4 (1.53.9)] and sleeping pills [3.1 (1.9-5.3)]. Proportions of CD patients using antidepressants (26%) and sleeping pills (22%) were unchanged at diagnosis and 5-year follow-up, whereas drugs for hypertension and diabetes decreased. Patients in sustained remission for median 9.3 years (interquartile range 8.1-10.4) had higher use of antidepressants [OR 2.0 (1.1-3.8)] and sleeping pills [2.4 (1.3-4.7)], but not of drugs for hypertension. Conclusions: Increased use of psychotropic drugs in CD was observed before diagnosis and remained elevated regardless of remission status, suggesting persisting negative effects on mental health. The study highlights the importance of early diagnosis of CD, and the need for long-term monitoring of mental health.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Ragnarsson, Oskar,1971Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Department of Internal Medicine and Clinical Nutrition, Institute of Medicine at Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; The Department of Endocrinology, Sahlgrenska University Hospital, Gothenburg, Sweden,Univ Gothenburg, Inst Med, Dept Internal Med & Clin Nutr, Sahlgrenska Acad, Gothenburg, Sweden.;Sahlgrens Univ Hosp, Dept Endocrinol, Gothenburg, Sweden.(Swepub:gu)xragos (author)
  • Berinder, K.Karolinska Institutet,Karolinska Institute,Department of Endocrinology, Karolinska University Hospital, Stockholm, Sweden; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden,Karolinska Univ Hosp, Dept Endocrinol, Stockholm, Sweden.;Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden. (author)
  • Dahlqvist, PerUmeå University,Umeå universitet,Avdelningen för medicin,Umeå Univ, Dept Publ Hlth & Clin Med, Umeå, Sweden.,Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden(Swepub:umu)perdat96 (author)
  • Edén Engström, BrittUppsala universitet,Linköping University,Uppsala University,Department of Medical Sciences, Endocrinology and Mineral Metabolism, Uppsala University, Uppsala, Sweden; Department of Endocrinology and Diabetes, Uppsala University Hospital, Uppsala, Sweden,Endokrinologi och mineralmetabolism,Uppsala Univ Hosp, Dept Endocrinol & Diabet, Uppsala, Sweden.(Swepub:uu)brittee (author)
  • Ekman, Bertil,1958-Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Endokrinmedicinska kliniken(Swepub:liu)berek83 (author)
  • Hoybye, C.Karolinska Institutet,Karolinska Institute,Department of Endocrinology, Karolinska University Hospital , Stockholm, Sweden; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden,Karolinska Univ Hosp, Dept Endocrinol, Stockholm, Sweden.;Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden. (author)
  • Burman, PiaLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Department of Endocrinology, Skåne University Hospital, University of Lund, Malmö, Sweden,Lund Univ, Skane Univ Hosp, Dept Endocrinol, Malmö, Sweden.(Swepub:lu)med-bap (author)
  • Wahlberg, Jeanette,1969-Linköpings universitet,Örebro University,Linköping University,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Endocrinology and Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden,Linköping Univ, Dept Endocrinol Linköping, Linköping, Sweden.;Linköping Univ, Dept Hlth Med & Caring Sci, Linköping, Sweden.;Örebro Univ, Fac Med Sci, Örebro, Sweden.,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Endokrinmedicinska kliniken(Swepub:liu)jeawa98 (author)
  • Linköping UniversityKalmar County Hospital (creator_code:org_t)

Related titles

  • In:Journal of Clinical Endocrinology & Metabolism: The Endocrine Society106:6, s. 1750-17600021-972X1945-7197

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