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Adiponectin Associa...
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Zhang, YuanGothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Wallenberg Centre for Molecular and Translational Medicine,Institute of Medicine, Department of Rheumatology and Inflammation Research
(author)
Adiponectin Associates with Rheumatoid Arthritis Risk in Overweight and Obesity Independently of Other Adipokines
- Article/chapterEnglish2021
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LIBRIS-ID:oai:gup.ub.gu.se/306265
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https://gup.ub.gu.se/publication/306265URI
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https://doi.org/10.3390/jcm10132791DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-187300URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:147019811URI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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We recently reported that increased serum adiponectin was associated with rheumatoid arthritis (RA) risk in subjects with obesity. We hereby aim to determine if other adipokines associate with RA risk and if the association between adiponectin and RA is independent of other adipokines. Two nested-case control studies were performed in two different cohorts: 82 participants of the Swedish Obese Subjects (SOS) study who developed RA during follow-up matched with 410 controls, and 88 matched pairs from the Medical Biobank of Northern Sweden. Baseline levels of circulating adipokines were measured using ELISA. In a multivariable analysis in the SOS cohort, higher adiponectin was associated with an increased risk of RA independently of other adipokines (OR for RA risk: 1.06, 95% CI: 1.01-1.12, p = 0.02). No association between leptin, resistin, and visfatin levels and the risk of RA was detected. In the cohort from the Medical Biobank of Northern Sweden, higher adiponectin was associated with an increased risk of RA only in participants with overweight/obesity (OR: 1.17, 95% CI: 1.01-1.36, p = 0.03), independently of other adipokines. Our results show that in individuals with overweight/obesity, higher circulating levels of adiponectin, but not leptin, resistin, or visfatin, were associated with an increased RA risk.
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Johansson, LindaUmeå universitet,Reumatologi(Swepub:umu)lijo0115
(author)
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Andersson-Assarsson, Johanna C.,1974Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xanjoh
(author)
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Taube, MagdalenaGothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xtaubm
(author)
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Peltonen, M.
(author)
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Svensson, Per-Arne,1969Gothenburg University,Göteborgs universitet,Institutionen för vårdvetenskap och hälsa,Institute of Health and Care Sciences(Swepub:gu)xsvper
(author)
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Herder, C.
(author)
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Rudin, Anna,1961Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research(Swepub:gu)xrudan
(author)
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Carlsson, Lena M S,1957Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xcarle
(author)
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Rantapää-Dahlqvist, SolbrittUmeå universitet,Reumatologi(Swepub:umu)sora0001
(author)
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Maglio, Cristina,1983Gothenburg University,Göteborgs universitet,Wallenberg Centre for Molecular and Translational Medicine(Swepub:gu)xmagcr
(author)
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Göteborgs universitetInstitutionen för medicin, avdelningen för reumatologi och inflammationsforskning
(creator_code:org_t)
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In:Journal of Clinical Medicine: MDPI AG10:132077-0383
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Zhang, Yuan
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Johansson, Linda
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Andersson-Assars ...
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Taube, Magdalena
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Peltonen, M.
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Svensson, Per-Ar ...
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Herder, C.
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Rudin, Anna, 196 ...
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Carlsson, Lena M ...
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Rantapää-Dahlqvi ...
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Maglio, Cristina ...
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- MEDICAL AND HEALTH SCIENCES
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and Clinical Medicin ...
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University of Gothenburg
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Umeå University
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Karolinska Institutet