Outcome after acute ischemic stroke is linked to sex-specific lesion patterns

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MARC

Bonkhoff, A. K.Massachusetts General Hospital (author)

Outcome after acute ischemic stroke is linked to sex-specific lesion patterns

Article/chapterEnglish2021

Publisher, publication year, extent ...

2021-06-02
Springer Science and Business Media LLC,2021

Numbers

LIBRIS-ID:oai:gup.ub.gu.se/306396
https://gup.ub.gu.se/publication/306396URI
https://doi.org/10.1038/s41467-021-23492-3DOI
https://lup.lub.lu.se/record/aba63928-44d6-4bb6-9bb9-7ea74c43c1abURI

Supplementary language notes

Language:English

Part of subdatabase

SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Acute ischemic stroke affects men and women differently. In particular, women are often reported to experience higher acute stroke severity than men. We derived a low-dimensional representation of anatomical stroke lesions and designed a Bayesian hierarchical modeling framework tailored to estimate possible sex differences in lesion patterns linked to acute stroke severity (National Institute of Health Stroke Scale). This framework was developed in 555 patients (38% female). Findings were validated in an independent cohort (n=503, 41% female). Here, we show brain lesions in regions subserving motor and language functions help explain stroke severity in both men and women, however more widespread lesion patterns are relevant in female patients. Higher stroke severity in women, but not men, is associated with left hemisphere lesions in the vicinity of the posterior circulation. Our results suggest there are sex-specific functional cerebral asymmetries that may be important for future investigations of sex-stratified approaches to management of acute ischemic stroke.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Neurovetenskaper hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Neurosciences hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Neurologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Neurology hsv//eng
aged
Bayes theorem
brain ischemia
brain mapping
brain stem
cerebral revascularization
cohort analysis
diagnostic imaging
female
human
image processing
male
middle aged
nuclear magnetic resonance imaging
pathology
procedures
risk factor
sensorimotor cortex
severity of illness index
sex factor
thalamus
treatment outcome
vascularization
very elderly
Aged
80 and over
Cohort Studies
Humans
Image Processing
Computer-Assisted
Ischemic Stroke
Magnetic Resonance Imaging
Risk Factors
Sex Factors
Aged, 80 and over
Bayes Theorem
Brain Mapping
Brain Stem
Cerebral Revascularization
Female
Image Processing, Computer-Assisted
Male
Middle Aged
Sensorimotor Cortex
Severity of Illness Index
Thalamus
Treatment Outcome

Added entries (persons, corporate bodies, meetings, titles ...)

Schirmer, M. D. (author)
Bretzner, M. (author)
Hong, S. (author)
Regenhardt, R. W. (author)
Brudfors, M. (author)
Donahue, K. L. (author)
Nardin, M. J. (author)
Dalca, A. V. (author)
Giese, A. K. (author)
Etherton, M. R. (author)
Hancock, B. L. (author)
Stanne, Tara M,1979Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Department of Laboratory Medicine(Swepub:gu)xmcdta (author)
McIntosh, E. C. (author)
Attia, J. (author)
Benavente, O. R. (author)
Bevan, S. (author)
Wasselius, JohanLund University,Lunds universitet,Diagnostisk radiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Diagnostic Radiology, (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital(Swepub:lu)oft-jws (author)
Donatti, A. (author)
Jern, Christina,1962Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Department of Laboratory Medicine(Swepub:gu)xjerch (author)
Heitsch, L. (author)
Holmegaard, LukasGothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience(Swepub:gu)xhollu (author)
Jood, Katarina,1966Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience(Swepub:gu)xjooka (author)
Jimenez-Conde, J. (author)
Kittner, S. J. (author)
Lemmens, R. (author)
Levi, C. R. (author)
McDonough, C. W. (author)
Meschia, J. F. (author)
Phuah, C. L. (author)
Rolfs, A. (author)
Ropele, S. (author)
Rosand, J. (author)
Roquer, J. (author)
Rundek, T. (author)
Sacco, R. L. (author)
Schmidt, R.Massachusetts General Hospital (author)
Sharma, P. (author)
Slowik, A. (author)
Söderholm, MartinLund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-ms8 (author)
Sousa, A. (author)
Stanne, Tara M,1979Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Department of Laboratory Medicine(Swepub:gu)xmcdta (author)
Strbian, D. (author)
Tatlisumak, TurgutGothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience(Swepub:gu)xtatlt (author)
Thijs, V. (author)
Vagal, A. (author)
Wasselius, J. (author)
Woo, D. (author)
Zand, R. (author)
McArdle, P. F. (author)
Worrall, B. B. (author)
Jern, Christina,1962Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Department of Laboratory Medicine(Swepub:gu)xjerch (author)
Lindgren, ArneLund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Klinisk strokeforskning,Forskargrupper vid Lunds universitet,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Clinical Stroke Research Group,Lund University Research Groups,Skåne University Hospital(Swepub:lu)neur-ali (author)
Maguire, J. (author)
Bzdok, D. (author)
Wu, O. (author)
Rost, N. S. (author)
Mri, Genie (author)
Massachusetts General HospitalInstitutionen för biomedicin, avdelningen för laboratoriemedicin (creator_code:org_t)
International Stroke Genetics Consortium

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By the author/editor: Bonkhoff, A. K.; Schirmer, M. D.; Bretzner, M.; Hong, S.; Regenhardt, R. W ...; Brudfors, M.; show more...; Donahue, K. L.; Nardin, M. J.; Dalca, A. V.; Giese, A. K.; Etherton, M. R.; Hancock, B. L.; Stanne, Tara M, ...; McIntosh, E. C.; Attia, J.; Benavente, O. R.; Bevan, S.; Wasselius, Johan; Donatti, A.; Jern, Christina, ...; Heitsch, L.; Holmegaard, Luka ...; Jood, Katarina, ...; Jimenez-Conde, J ...; Kittner, S. J.; Lemmens, R.; Levi, C. R.; McDonough, C. W.; Meschia, J. F.; Phuah, C. L.; Rolfs, A.; Ropele, S.; Rosand, J.; Roquer, J.; Rundek, T.; Sacco, R. L.; Schmidt, R.; Sharma, P.; Slowik, A.; Söderholm, Marti ...; Sousa, A.; Strbian, D.; Tatlisumak, Turg ...; Thijs, V.; Vagal, A.; Wasselius, J.; Woo, D.; Zand, R.; McArdle, P. F.; Worrall, B. B.; Lindgren, Arne; Maguire, J.; Bzdok, D.; Wu, O.; Rost, N. S.; Mri, Genie; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Neurosciences

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Neurology

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By the university: University of Gothenburg; Lund University

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