Search: id:"swepub:oai:gup.ub.gu.se/306477" >
Csf metabolites ass...
Csf metabolites associate with csf tau and improve prediction of alzheimer’s disease status
- Article/chapterEnglish2021
Publisher, publication year, extent ...
Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/306477
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https://gup.ub.gu.se/publication/306477URI
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https://doi.org/10.1002/dad2.12167DOI
Supplementary language notes
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Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Introduction: Cerebrospinal fluid (CSF) total tau (t-tau) and phosphorylated tau (p-tau) are biomarkers of Alzheimer’s disease (AD), yet much is unknown about AD-associated changes in tau metabolism and tau tangle etiology. Methods: We assessed the variation of t-tau and p-tau explained by 38 previously identified CSF metabolites using linear regression models in middle-age controls from the Wisconsin Alzheimer’s Disease Research Center, and predicted AD/mild cognitive impairment (MCI) versus an independent set of older controls using metabolites selected by the least absolute shrinkage and selection operator (LASSO). Results: The 38 CSF metabolites explained 70.3% and 75.7% of the variance in t-tau and p-tau, respectively. Of these, seven LASSO-selected metabolites improved the prediction ability of AD/MCI versus older controls (area under the curve score increased from 0.92 to 0.97 and 0.78 to 0.93) compared to the base model. Discussion: These tau-correlated CSF metabolites increase AD/MCI prediction accuracy and may provide insight into tau tangle etiology. © 2021 The Authors.
Subject headings and genre
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MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Neurovetenskaper hsv//swe
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MEDICAL AND HEALTH SCIENCES Basic Medicine Neurosciences hsv//eng
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Alzheimer’s disease
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Cerebrospinal fluid
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Metabolite
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Metabolomics
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P-tau
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T-tau
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1 myristoyl 2 palmitoyl gpc
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1 oleoyl gpc
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1 palmitoyl gpc
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arabinitol
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arabinose
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biological marker
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C glycosyl tryptophan
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glucuronic acid
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gulonate
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n acetylneuraminate
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nucleotide derivative
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pentose
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tau protein
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tryptophan
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unclassified drug
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x 10457
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x 24228
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xylitol
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adult
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aged
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Alzheimer disease
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Article
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biological functions
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clinical outcome
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cognitive defect
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cohort analysis
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controlled study
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female
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glycerophospholipid metabolism
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groups by age
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human
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major clinical study
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male
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middle aged
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phospholipid metabolism
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prediction
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protein blood level
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protein cerebrospinal fluid level
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protein phosphorylation
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sex difference
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variance
Added entries (persons, corporate bodies, meetings, titles ...)
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Darst, B. F.
(author)
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Deming, Y.
(author)
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Ma, Y.
(author)
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Lu, Q.
(author)
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Zetterberg, Henrik,1973Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology(Swepub:gu)xzethe
(author)
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Blennow, Kaj,1958Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology(Swepub:gu)xbleka
(author)
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Carlsson, C. M.
(author)
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Johnson, S. C.
(author)
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Asthana, S.
(author)
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Engelman, C. D.
(author)
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Göteborgs universitetInstitutionen för neurovetenskap och fysiologi
(creator_code:org_t)
Related titles
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In:Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring: Wiley13:12352-8729
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- By the author/editor
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Dong, R.
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Darst, B. F.
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Deming, Y.
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Ma, Y.
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Lu, Q.
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Zetterberg, Henr ...
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show more...
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Blennow, Kaj, 19 ...
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Carlsson, C. M.
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Johnson, S. C.
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Asthana, S.
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Engelman, C. D.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Alzheimer's and ...
- By the university
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University of Gothenburg