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Discriminative accu...
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Pascoal, Tharick A.University of Pittsburgh,McGill University Research Centre for Studies in Aging
(author)
Discriminative accuracy of the A/T/N scheme to identify cognitive impairment due to Alzheimer's disease
- Article/chapterEnglish2023
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LIBRIS-ID:oai:lup.lub.lu.se:3c2443fc-f037-4884-b1a0-90945a11bc1f
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https://lup.lub.lu.se/record/3c2443fc-f037-4884-b1a0-90945a11bc1fURI
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https://doi.org/10.1002/dad2.12390DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Introduction: The optimal combination of amyloid-β/tau/neurodegeneration (A/T/N) biomarker profiles for the diagnosis of Alzheimer's disease (AD) dementia is unclear. Methods: We examined the discriminative accuracy of A/T/N combinations assessed with neuroimaging biomarkers for the differentiation of AD from cognitively unimpaired (CU) elderly and non-AD neurodegenerative diseases in the TRIAD, BioFINDER-1 and BioFINDER-2 cohorts (total n = 832) using area under the receiver operating characteristic curves (AUC). Results: For the diagnosis of AD dementia (vs. CU elderly), T biomarkers performed as well as the complete A/T/N system (AUC range: 0.90–0.99). A and T biomarkers in isolation performed as well as the complete A/T/N system in differentiating AD dementia from non-AD neurodegenerative diseases (AUC range; A biomarker: 0.84–1; T biomarker: 0.83–1). Discussion: In diagnostic settings, the use of A or T neuroimaging biomarkers alone can reduce patient burden and medical costs compared with using their combination, without significantly compromising accuracy.
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Leuzy, AntoineLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups(Swepub:lu)an3415le
(author)
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Therriault, JosephMontreal Neurological Institute & Hospital,McGill University Research Centre for Studies in Aging
(author)
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Chamoun, MiraMontreal Neurological Institute & Hospital,McGill University Research Centre for Studies in Aging
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Lussier, FirozaUniversity of Pittsburgh,McGill University Research Centre for Studies in Aging
(author)
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Tissot, CecileLund University,University of Pittsburgh
(author)
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Strandberg, OlofLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital(Swepub:lu)teor-osn
(author)
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Palmqvist, SebastianLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-spa
(author)
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Stomrud, ErikLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-esr
(author)
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Ferreira, Pamela C.L.University of Pittsburgh
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Ferrari-Souza, João PedroUniversity of Pittsburgh,Federal University of Rio Grande do Sul
(author)
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Smith, RubenLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Regeneration in Movement Disorders,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital(Swepub:lu)mphy-rsm
(author)
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Benedet, Andrea LessaMcGill University Research Centre for Studies in Aging,Montreal Neurological Institute & Hospital
(author)
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Gauthier, SergeMcGill University Research Centre for Studies in Aging
(author)
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Hansson, OskarLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital(Swepub:lu)mphy-ohn
(author)
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Rosa-Neto, PedroMontreal Neurological Institute & Hospital,McGill University Research Centre for Studies in Aging
(author)
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University of PittsburghMcGill University Research Centre for Studies in Aging
(creator_code:org_t)
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In:Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring: Wiley15:12352-8729
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Pascoal, Tharick ...
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Leuzy, Antoine
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Therriault, Jose ...
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Chamoun, Mira
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Lussier, Firoza
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Tissot, Cecile
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Strandberg, Olof
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Palmqvist, Sebas ...
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Stomrud, Erik
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Ferreira, Pamela ...
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Ferrari-Souza, J ...
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Smith, Ruben
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Benedet, Andrea ...
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Gauthier, Serge
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Hansson, Oskar
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Rosa-Neto, Pedro
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- MEDICAL AND HEALTH SCIENCES
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and Basic Medicine
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Alzheimer's and ...
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Lund University