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  • Pascoal, Tharick A.University of Pittsburgh,McGill University Research Centre for Studies in Aging (author)

Discriminative accuracy of the A/T/N scheme to identify cognitive impairment due to Alzheimer's disease

  • Article/chapterEnglish2023

Publisher, publication year, extent ...

  • 2023-01-30
  • Wiley,2023

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:3c2443fc-f037-4884-b1a0-90945a11bc1f
  • https://lup.lub.lu.se/record/3c2443fc-f037-4884-b1a0-90945a11bc1fURI
  • https://doi.org/10.1002/dad2.12390DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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Classification

  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Introduction: The optimal combination of amyloid-β/tau/neurodegeneration (A/T/N) biomarker profiles for the diagnosis of Alzheimer's disease (AD) dementia is unclear. Methods: We examined the discriminative accuracy of A/T/N combinations assessed with neuroimaging biomarkers for the differentiation of AD from cognitively unimpaired (CU) elderly and non-AD neurodegenerative diseases in the TRIAD, BioFINDER-1 and BioFINDER-2 cohorts (total n = 832) using area under the receiver operating characteristic curves (AUC). Results: For the diagnosis of AD dementia (vs. CU elderly), T biomarkers performed as well as the complete A/T/N system (AUC range: 0.90–0.99). A and T biomarkers in isolation performed as well as the complete A/T/N system in differentiating AD dementia from non-AD neurodegenerative diseases (AUC range; A biomarker: 0.84–1; T biomarker: 0.83–1). Discussion: In diagnostic settings, the use of A or T neuroimaging biomarkers alone can reduce patient burden and medical costs compared with using their combination, without significantly compromising accuracy.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Leuzy, AntoineLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups(Swepub:lu)an3415le (author)
  • Therriault, JosephMontreal Neurological Institute & Hospital,McGill University Research Centre for Studies in Aging (author)
  • Chamoun, MiraMontreal Neurological Institute & Hospital,McGill University Research Centre for Studies in Aging (author)
  • Lussier, FirozaUniversity of Pittsburgh,McGill University Research Centre for Studies in Aging (author)
  • Tissot, CecileLund University,University of Pittsburgh (author)
  • Strandberg, OlofLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital(Swepub:lu)teor-osn (author)
  • Palmqvist, SebastianLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-spa (author)
  • Stomrud, ErikLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-esr (author)
  • Ferreira, Pamela C.L.University of Pittsburgh (author)
  • Ferrari-Souza, João PedroUniversity of Pittsburgh,Federal University of Rio Grande do Sul (author)
  • Smith, RubenLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Regeneration in Movement Disorders,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital(Swepub:lu)mphy-rsm (author)
  • Benedet, Andrea LessaMcGill University Research Centre for Studies in Aging,Montreal Neurological Institute & Hospital (author)
  • Gauthier, SergeMcGill University Research Centre for Studies in Aging (author)
  • Hansson, OskarLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital(Swepub:lu)mphy-ohn (author)
  • Rosa-Neto, PedroMontreal Neurological Institute & Hospital,McGill University Research Centre for Studies in Aging (author)
  • University of PittsburghMcGill University Research Centre for Studies in Aging (creator_code:org_t)

Related titles

  • In:Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring: Wiley15:12352-8729

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