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The enigmatic RNase...
The enigmatic RNase MRP of kinetoplastids
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- Alm Rosenblad, Magnus, 1957 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology
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- Dávila López, Marcela (author)
- Gothenburg University,Göteborgs universitet,Core Facilities, Bioinformatics,Core Facilities, Bioinformatics
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- Samuelsson, Tore, 1951 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
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(creator_code:org_t)
- 2021-07-25
- 2021
- English.
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In: Rna Biology. - : Informa UK Limited. - 1547-6286 .- 1555-8584. ; 18:Supplement 1, s. 139-147
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Abstract
Subject headings
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- The ribonucleoprotein RNase MRP is responsible for the processing of ribosomal RNA precursors. It is found in virtually all eukaryotes that have been examined. In the Euglenozoa, including the genera Euglena, Diplonema and kinetoplastids, MRP RNA and protein subunits have so far escaped detection using bioinformatic methods. However, we now demonstrate that the RNA component is widespread among the Euglenozoa and that these RNAs have secondary structures that conform to the structure of all other phylogenetic groups. In Euglena, we identified the same set of P/MRP protein subunits as in many other protists. However, we failed to identify any of these proteins in the kinetoplastids. This finding poses interesting questions regarding the structure and function of RNase MRP in these species.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- MRP
- RNA
- ribosomal RNA processing
- bioinformatics
- Euglenozoa
- kinetoplastids
- trypanosoma-brucei reveals
- cell-cycle progression
- alignment
- resource
- homology
- c/d
- Biochemistry & Molecular Biology
Publication and Content Type
- ref (subject category)
- art (subject category)
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