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  • Sjölander, MariaUmeå universitet,Avdelningen för medicin (författare)

Prescription of Lipid-Lowering and Antihypertensive Drugs Following Pictorial Information About Subclinical Atherosclerosis A Secondary Outcome of a Randomized Clinical Trial

  • Artikel/kapitelEngelska2021

Förlag, utgivningsår, omfång ...

  • 2021-08-19
  • American Medical Association (AMA),2021

Nummerbeteckningar

  • LIBRIS-ID:oai:gup.ub.gu.se/307669
  • https://gup.ub.gu.se/publication/307669URI
  • https://doi.org/10.1001/jamanetworkopen.2021.21683DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-187088URI

Kompletterande språkuppgifter

  • Språk:engelska

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  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • IMPORTANCE Preventive drugs are often underused. Carotid intima-media thickness and carotid plaques are associated with cardiovascular disease (CVD), and their detection could possibly improve estimation of the likelihood of CVD and prescription of preventive drugs. OBJECTIVE To evaluate whether pictorial information on participants' asymptomatic atherosclerosis based on carotid ultrasonographic examinations to participants and their physicians had an effect on prescribing of lipid-lowering or antihypertensive drugs during the following 465 days. DESIGN, SETTING, AND PARTICIPANTS Visualization of Asymptomatic Atherosclerotic Disease for Optimum Cardiovascular Prevention is a pragmatic randomized clinical trial nested within the Vasterbotten Intervention Program, a CVD screening and prevention program in Sweden with 60% to 70% participation rates and small social selection bias. A total of 4177 individuals aged 40, 50, or 60 years participating in the Vasterbotten Intervention Program who had low to moderate risk of CVD were invited to enroll in this trial from April 29, 2013, to June 7, 2016. Prescriptions for all participants were monitored for 465 days after the intervention. Data analysis was conducted from December 6, 2019, to April 2, 2020. INTERVENTIONS Participants and their family physicians were randomly assigned 1:1 to receive or not receive pictorial information from carotid ultrasonographic determination of vascular age, assessed as carotid intima-media thickness and the presence of carotid plaques, combined with a follow-up call to participants by nurses. MAIN OUTCOMES AND MEASURES Two outcome measures of prescriptions of antihypertensive and lipid-lowering drugs within 465 days after ultrasonography was performed. Data obtained through intention-to-treat analysis are presented as proportions of individuals with a prescription among those who had no baseline prescription for agents from these drug classes. RESULTS Of the 4177 individuals invited to enroll, 3532 participants were randomized and included in the analysis; 1870 (52.9%) were women, 2278 (64.5%) were aged 60 years, 978 (27.7%) were 50 years, and 276 (7.8%) were 40 years. First prescriptions of lipid-lowering drugs were higher in the intervention group vs the control group among men (118 of 639 [18.5%] vs 38 of 692 [5.5%]; P < .001) and women (126 of 804 [15.5%] vs 38 of 817 [4.7%]; P < .001). There were no significant differences in the proportion with prescription of antihypertensive drugs in the intervention vs control groups after ultrasonography among men (58 of 482 [12.0%] vs 56 of 528 [10.6%]; P = .47) and women (60 of 612 [9.8%] vs 64 of 615 [10.4%]; P = .73). CONCLUSIONS AND RELEVANCE The findings of this trial demonstrate that provision of pictorial information on vascular age and carotid plaques based on the results of ultrasonographic examination increased physician prescription of lipid-lowering drugs but not antihypertensive drugs within the following 465 days.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Carlberg, BoUmeå universitet,Avdelningen för medicin(Swepub:umu)boca0001 (författare)
  • Norberg, MargaretaUmeå universitet,Avdelningen för medicin(Swepub:umu)mano0062 (författare)
  • Näslund, UlfUmeå universitet,Avdelningen för medicin,Arcum(Swepub:umu)ulna0002 (författare)
  • Ng, Nawi,1974Umeå universitet,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine,Institutionen för epidemiologi och global hälsa,School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden,Arcum(Swepub:umu)ngna0002 (författare)
  • Umeå universitetAvdelningen för medicin (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Jama Network Open: American Medical Association (AMA)4:82574-3805

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Av författaren/redakt...
Sjölander, Maria
Carlberg, Bo
Norberg, Margare ...
Näslund, Ulf
Ng, Nawi, 1974
Om ämnet
MEDICIN OCH HÄLSOVETENSKAP
MEDICIN OCH HÄLS ...
och Klinisk medicin
MEDICIN OCH HÄLSOVETENSKAP
MEDICIN OCH HÄLS ...
och Klinisk medicin
och Kardiologi
MEDICIN OCH HÄLSOVETENSKAP
MEDICIN OCH HÄLS ...
och Medicinska och f ...
och Samhällsfarmaci ...
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Jama Network Ope ...
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Göteborgs universitet
Umeå universitet

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