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Treatment of patien...
Treatment of patients with Graves' disease in Sweden compared to international surveys of an 'index patient'
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- Sjölin, Gabriel, 1979- (author)
- Faculty of Medicine and Health, Örebro University Hospital, Örebro, Sweden,Orebro Univ Hosp, Fac Med & Hlth, Orebro, Sweden.
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- Byström, Kristina, 1961- (author)
- Örebro University,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Medicine Örebro University Hospital, Örebro, Sweden,Orebro Univ & Univ Hosp, Dept Med, Orebro, Sweden.
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- Holmberg, Mats, 1958 (author)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine,Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden; ANOVA, Karolinska University Hospital, Stockholm, Sweden,Univ Gothenburg, Sahlgrenska Acad, Inst Med, Gothenburg, Sweden.;Karolinska Univ Hosp, ANOVA, Stockholm, Sweden.
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- Torring, O. (author)
- Karolinska Institute,Karolinska Inst, Inst Clin Sci & Educ, Stockholm, Sweden.
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- Khamisi, Selwan (author)
- Uppsala universitet,Uppsala University,Uppsala University Hospital,Endokrinologi och mineralmetabolism
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- Calissendorff, J. (author)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital,Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Endocrinol Metab & Diabet, Stockholm, Sweden.
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- Lantz, Mikael (author)
- Lund University,Lunds universitet,Translationell Muskel Forskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,Skåne University Hospital,Skane Univ Hosp, Dept Endocrinol, Malmo, Sweden.;Lund Univ, Dept Clin Sci, Lund, Sweden.
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- Hallengren, Bengt (author)
- Lund University,Lunds universitet,Translationell Muskel Forskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,Skåne University Hospital,Skane Univ Hosp, Dept Endocrinol, Malmo, Sweden.;Lund Univ, Dept Clin Sci, Lund, Sweden.
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- Nyström, Helena Filipsson, 1966 (author)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Wallenberg Centre for Molecular and Translational Medicine,Institutionen för medicin,Institute of Medicine,Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden; Department of Endocrinology, Sahlgrenska University Hospital, Göteborg, Sweden; Wallenberg Center for Molecular and Translational Medicine, Göteborg, Sweden,Univ Gothenburg, Sahlgrenska Acad, Inst Med, Gothenburg, Sweden.;Sahlgrens Univ Hosp, Dept Endocrinol, Gothenburg, Sweden.;Wallenberg Ctr Mol & Translat Med, Gothenburg, Sweden.
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- Planck, Tereza (author)
- Lund University,Lunds universitet,Translationell Muskel Forskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,Skåne University Hospital,Skane Univ Hosp, Dept Endocrinol, Malmo, Sweden.;Lund Univ, Dept Clin Sci, Lund, Sweden.
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- Wallin, G. (author)
- Karolinska Institutet,Karolinska Institute,Örebro University Hospital,Orebro Univ Hosp, Fac Med & Hlth, Orebro, Sweden.;Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.
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Faculty of Medicine and Health, Örebro University Hospital, Örebro, Sweden Orebro Univ Hosp, Fac Med & Hlth, Orebro, Sweden (creator_code:org_t)
- 2021-03-16
- 2021
- English.
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In: Endocrinology, Diabetes & Metabolism. - : Wiley. - 2398-9238. ; 4:3
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Abstract
Subject headings
Close
- Introduction The treatment strategies for a 42-year-old female index patient with moderate Graves' disease (GD) vary according to several international surveys. The important question whether surveys of treatment preferences in theoretical patient cases also match how real patients are treated has not yet been addressed. Materials and Methods From a Swedish cohort of 1186 GD patients (TT-12 cohort), 27 women were identified using the same criteria as from the index patient surveys from the European and American Thyroid Associations. This 'index patient cohort' was age 40-45, otherwise healthy female, with two children and uncomplicated GD. The applied first-line treatment of the patients in the index cohort, together with its variations, was compared with the treatment preferences according to international surveys. A comparison with the TT-12 cohort was also performed. Results In the 'Index cohort', 77.8% were treated with antithyroid drugs (ATD), and 22.2% were treated with radioiodine (I-131). This preference for ATD is in line with most countries/regions, with the exception of USA and the Middle East/North Africa, where I-131 was preferred. The distribution of treatment in the TT-12 cohort did not significantly differ from the index cohort. ATD was the preferred treatment in male and young (age 19-22) patients, as was RAI in old (age 69-73) patients. The age-related, but not the gender-related, cases differed significantly from the entire TT-12 cohort. Conclusion The treatment choice in an index patient in Sweden seems in line with European practice, where ATD is the preferred first choice. This differs compared to US and North African survey intentions, where I-131 is more often used. Age more than gender influences the treatment choice of GD patients. This is, to our best knowledge, the first time an index patient from 'real life' has been presented and compared to treatment preferences of international thyroid association surveys.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- antithyroid drugs
- Graves' disease
- hyperthyroidism
- index patient
- international surveys
- long-term follow-up
- radioactive iodine
- thyroidectomy
- treatment options
- clinical-practice patterns
- case selection
- new-zealand
- management
- hyperthyroidism
- therapy
- ophthalmopathy
- diagnosis
- trends
- japan
- Endocrinology & Metabolism
- Graves’ disease
- Graves’ disease
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Sjölin, Gabriel, ...
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Byström, Kristin ...
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Holmberg, Mats, ...
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Torring, O.
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Khamisi, Selwan
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Calissendorff, J ...
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Lantz, Mikael
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Hallengren, Beng ...
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Nyström, Helena ...
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Planck, Tereza
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Wallin, G.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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Endocrinology, D ...
- By the university
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University of Gothenburg
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Örebro University
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Lund University
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Uppsala University
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Karolinska Institutet