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Spatial modeling of...
Spatial modeling of epidermal nerve fiber patterns
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- Konstantionu, Konstantinos (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för matematiska vetenskaper,Department of Mathematical Sciences,Chalmers tekniska högskola,Chalmers University of Technology,University of Gothenburg
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- Särkkä, Aila, 1962 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för matematiska vetenskaper,Department of Mathematical Sciences,Chalmers tekniska högskola,Chalmers University of Technology,University of Gothenburg
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(creator_code:org_t)
- 2021-09-14
- 2021
- Engelska.
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Ingår i: Statistics in Medicine. - : Wiley. - 0277-6715 .- 1097-0258. ; 40:29, s. 6479-6500
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Abstract
Ämnesord
Stäng
- Peripheral neuropathy is a condition associated with poor nerve functionality. Epidermal nerve fiber (ENF) counts per epidermal surface are dramatically reduced and the two-dimensional (2D) spatial structure of ENFs tends to become more clustered as neuropathy progresses. Therefore, studying the spatial structure of ENFs is essential to fully understand the mechanisms that guide those morphological changes. In this article, we compare ENF patterns of healthy controls and subjects suffering from mild diabetic neuropathy by using suction skin blister specimens obtained from the right foot. Previous analysis of these data has focused on the analysis and modeling of the spatial ENF patterns consisting of the points where the nerves enter the epidermis, base points, and the points where the nerve fibers terminate, end points, projected on a 2D plane, regarding the patterns as realizations of spatial point processes. Here, we include the first branching points, the points where the nerve trees branch for the first time, and model the three-dimensional (3D) patterns consisting of these three types of points. To analyze the patterns, spatial summary statistics are used and a new epidermal active territory that measures the volume in the epidermis that is covered by the individual nerve fibers is constructed. We developed a model for both the 2D and the 3D patterns including the branching points. Also, possible competitive behavior between individual nerves is examined. Our results indicate that changes in the ENFs spatial structure can more easily be detected in the later parts of the ENFs.
Ämnesord
- NATURVETENSKAP -- Matematik (hsv//swe)
- NATURAL SCIENCES -- Mathematics (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Industriell bioteknik -- Bioteknisk apparatteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Industrial Biotechnology -- Bioengineering Equipment (hsv//eng)
- NATURVETENSKAP -- Geovetenskap och miljövetenskap -- Naturgeografi (hsv//swe)
- NATURAL SCIENCES -- Earth and Related Environmental Sciences -- Physical Geography (hsv//eng)
- NATURVETENSKAP -- Geovetenskap och miljövetenskap -- Multidisciplinär geovetenskap (hsv//swe)
- NATURAL SCIENCES -- Earth and Related Environmental Sciences -- Geosciences, Multidisciplinary (hsv//eng)
Nyckelord
- branching point
- competition
- end point
- epidermal active territory
- point process
- two-step model
- 2nd-order analysis
- point patterns
- Mathematical & Computational Biology
- Public
- Occupational Health
- Medical Informatics
- Research & Experimental
- Medicine
- Mathematics
- two-step model
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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