Sökning: WFRF:(Lundkvist L) >
High dose pollen in...
High dose pollen intralymphatic immunotherapy: Two RDBPC trials question the benefit of dose increase
-
- Hellkvist, L. (författare)
- Karolinska Institute,Karolinska Institutet,Karolinska University Hospital
-
- Hjalmarsson, E. (författare)
- Karolinska Institute,Karolinska Institutet
-
Weinfeld, D. (författare)
-
visa fler...
-
- Dahl, Åslög, 1955 (författare)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för biologi och miljövetenskap,Department of Biological and Environmental Sciences
-
- Karlsson, A. (författare)
- Karolinska Institute,Karolinska University Hospital
-
- Westman, M. (författare)
- Karolinska Institute
-
- Lundkvist, K. (författare)
- Karolinska Institute
-
- Winqvist, O. (författare)
- Karolinska Institute
-
- Georen, S. K. (författare)
- Karolinska Institute,Karolinska Institutet
-
- Westin, Ulla (författare)
- Lund University,Lunds universitet,Laryngoesofagologi, allergi och livskvalitet,Forskargrupper vid Lunds universitet,Laryngoesophagology, Allergy and Life Quality,Lund University Research Groups,Skåne University Hospital
-
- Cardell, L. O. (författare)
- Karolinska Institute,Karolinska Institutet,Karolinska University Hospital
-
visa färre...
-
(creator_code:org_t)
- 2021-08-29
- 2022
- Engelska.
-
Ingår i: Allergy. - : Wiley. - 0105-4538 .- 1398-9995. ; 77:3, s. 883-96
- Relaterad länk:
-
https://onlinelibrar...
-
visa fler...
-
http://dx.doi.org/10... (free)
-
https://gup.ub.gu.se...
-
https://doi.org/10.1...
-
http://kipublication...
-
https://lup.lub.lu.s...
-
visa färre...
Abstract
Ämnesord
Stäng
- Background The same dosing schedule, 1000 SQ-U times three, with one-month intervals, have been evaluated in most trials of intralymphatic immunotherapy (ILIT) for the treatment of allergic rhinitis (AR). The present studies evaluated if a dose escalation in ILIT can enhance the clinical and immunological effects, without compromising safety. Methods Two randomized double-blind placebo-controlled trials of ILIT for grass pollen-induced AR were performed. The first included 29 patients that had recently ended 3 years of SCIT and the second contained 39 not previously vaccinated patients. An up-dosage of 1000-3000-10,000 (5000 + 5000 with 30 minutes apart) SQ-U with 1 month in between was evaluated. Results Doses up to 10,000 SQ-U were safe after recent SCIT. The combined symptom-medication scores (CSMS) were reduced by 31% and the grass-specific IgG4 levels in blood were doubled. In ILIT de novo, the two first patients that received active treatment developed serious adverse reactions at 5000 SQ-U. A modified up-dosing schedule; 1000-3000-3000 SQ-U appeared to be safe but failed to improve the CSMS. Flow cytometry analyses showed increased activation of lymph node-derived dendritic but not T cells. Quality of life and nasal provocation response did not improve in any study. Conclusion Intralymphatic immunotherapy in high doses after SCIT appears to further reduce grass pollen-induced seasonal symptoms and may be considered as an add-on treatment for patients that do not reach full symptom control after SCIT. Up-dosing schedules de novo with three monthly injections that exceeds 3000 SQ-U should be avoided.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Nyckelord
- clinical immunology
- immunotherapy and tolerance induction
- pollen
- rhinitis
- allergen-specific immunotherapy
- recombinant allergens
- young-adults
- clinical-use
- efficacy
- route
- rhinoconjunctivitis
- injections
- rhinitis
- asthma
- Allergy
- Immunology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
-
Allergy
(Sök värdpublikationen i LIBRIS)
Till lärosätets databas
- Av författaren/redakt...
-
Hellkvist, L.
-
Hjalmarsson, E.
-
Weinfeld, D.
-
Dahl, Åslög, 195 ...
-
Karlsson, A.
-
Westman, M.
-
visa fler...
-
Lundkvist, K.
-
Winqvist, O.
-
Georen, S. K.
-
Westin, Ulla
-
Cardell, L. O.
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Medicinska och f ...
-
och Immunologi inom ...
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Lungmedicin och ...
- Artiklar i publikationen
-
Allergy
- Av lärosätet
-
Göteborgs universitet
-
Karolinska Institutet
-
Lunds universitet