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  • Lantero Rodriguez, MartaGothenburg University,Göteborgs universitet,Wallenberg Centre for Molecular and Translational Medicine (author)

Testosterone reduces metabolic brown fat activity in male mice

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • Bioscientifica,2021
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/308101
  • https://gup.ub.gu.se/publication/308101URI
  • https://doi.org/10.1530/joe-20-0263DOI

Supplementary language notes

  • Language:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Brown adipose tissue (BAT) burns substantial amounts of mainly lipids to produce heat. Some studies indicate that BAT activity and core body temperature are lower in males than females. Here we investigated the role of testosterone and its receptor (the androgen receptor; AR) in metabolic BAT activity in male mice. Castration, which renders mice testosterone deficient, slightly promoted the expression of thermogenic markers in BAT, decreased BAT lipid content, and increased basal lipolysis in isolated brown adipocytes. Further, castration increased the core body temperature. Triglyceride-derived fatty acid uptake, a proxy for metabolic BAT activity in vivo, was strongly increased in BAT from castrated mice ( 4.5-fold increase vs sham-castrated mice) and testosterone replacement reversed the castration-induced increase in metabolic BAT activity. BAT-specific AR deficiency did not mimic the castration effects in vivo and AR agonist treatment did not diminish the activity of cultured brown adipocytes in vitro, suggesting that androgens do not modulate BAT activity via a direct, AR-mediated pathway. In conclusion, testosterone is a negative regulator of metabolic BAT activity in male mice. Our findings provide new insight into the metabolic actions of testosterone.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Schilperoort, M. (author)
  • Johansson, Inger,1962Gothenburg University,Göteborgs universitet,Wallenberg Centre for Molecular and Translational Medicine(Swepub:gu)xjingf (author)
  • Svedlund Eriksson, ElinGothenburg University,Göteborgs universitet,Wallenberg Centre for Molecular and Translational Medicine(Swepub:gu)xsvede (author)
  • Palsdottir, Vilborg,1979Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology(Swepub:gu)xpalvi (author)
  • Kroon, J. (author)
  • Henricsson, Marcus,1975Gothenburg University,Göteborgs universitet,Wallenberg Centre for Molecular and Translational Medicine(Swepub:gu)xstahm (author)
  • Kooijman, S. (author)
  • Ericson, Mia,1970Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xerimi (author)
  • Borén, Jan,1963Gothenburg University,Göteborgs universitet,Wallenberg Centre for Molecular and Translational Medicine(Swepub:gu)xborej (author)
  • Ohlsson, Claes,1965Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition(Swepub:gu)xohlcl (author)
  • Jansson, John-Olov,1954Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology(Swepub:gu)xjanjo (author)
  • Levin, Malin,1973Gothenburg University,Göteborgs universitet,Wallenberg Centre for Molecular and Translational Medicine(Swepub:gu)xlevim (author)
  • Rensen, P. C. N. (author)
  • Tivesten, Åsa,1969Gothenburg University,Göteborgs universitet,Wallenberg Centre for Molecular and Translational Medicine(Swepub:gu)xtivas (author)
  • Göteborgs universitetWallenberg Centre for Molecular and Translational Medicine (creator_code:org_t)

Related titles

  • In:Journal of Endocrinology: Bioscientifica251:1, s. 83-960022-07951479-6805

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