Increased risk for dementia in neurofibromatosis type 1

Purpose To determine the risk for dementia in neurofibromatosis type 1 (NF1) using a Finnish nationwide cohort of individuals with NF1, and data from national registries. Methods A Finnish cohort of 1,349 individuals with confirmed NF1 according to the US National Institutes of Health (NIH) diagnostic criteria was compared with a control cohort of 13,870 individuals matched for age, sex, and area of residence. Dementia-related hospital visits were retrieved from the Finnish Care Register for Health Care using International Classification of Diseases, 10th revision (ICD-10) diagnosis codes G30 and F00-F03. Purchases of antidementia drugs were queried with Anatomical Therapeutic Chemical (ATC) classification code N06D from the drug reimbursement register maintained by the Social Insurance Institution of Finland. The follow-up spanned 1998-2014. Results Totals of 16 and 165 individuals with at least two dementia-related diagnoses or drug purchases were identified in the NF1 and control cohorts, respectively. The hazard ratio for dementia in NF1 was 1.67 (95% confidence interval [CI] 1.00-2.80, P = 0.050). In an analysis stratified by the type of dementia, the risk for Alzheimer disease was increased in NF1 compared to controls with a hazard ratio of 2.88 (95% CI 1.47-5.66, P = 0.002). Conclusion Dementia and especially Alzheimer disease are previously unrecognized neurological complications of NF1.

Valtanen, M. (författare)
Auranen, K. (författare)
Uusitalo, E. (författare)
Rinne, J. O. (författare)
Peltonen, Sirkku,1964Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för dermatologi och venereologi,Institute of Clinical Sciences, Department of Dermatology and Venereology(Swepub:gu)xpelsi (författare)
Peltonen, J. (författare)
Göteborgs universitetInstitutionen för kliniska vetenskaper, Avdelningen för dermatologi och venereologi (creator_code:org_t)

Av författaren/redakt...: Kallionpaa, R. A ...; Valtanen, M.; Auranen, K.; Uusitalo, E.; Rinne, J. O.; Peltonen, Sirkku ...; visa fler...; Peltonen, J.; visa färre...

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