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  • Yaqub, S.Department of Hepato-Pancreato-Biliary Surgery, Oslo University Hospital, Oslo, Norway. shya@ous-hf.no; Institute of Clinical Medicine, University of Oslo, Oslo, Norway,Oslo Univ Hosp, Dept Hepato Pancreato Biliary Surg, Oslo, Norway.;Univ Oslo, Inst Clin Med, Oslo, Norway. (author)

Aspirin as secondary prevention in colorectal cancer liver metastasis (ASAC trial): study protocol for a multicentre randomized placebo-controlled trial

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • 2021-09-20
  • London, United Kingdom :Springer Science and Business Media LLC,2021

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/308596
  • https://gup.ub.gu.se/publication/308596URI
  • https://doi.org/10.1186/s13063-021-05587-wDOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-188164URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-185155URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-457481URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:147744903URI

Supplementary language notes

  • Language:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding agencies: The Research Council of Norway (Project#:235340); The Norwegian Cancer Society (Project# 182788); and KLINBEFORSK (Project#; 2016201). The funding body is not involved in study design, collection or interpretation of data nor in publication/writing of study results.The ASAC study group: Kristoffer W. Brudvik, Åsmund A. Fretland, Arild Horn, Dyre Kleive, Knut J. Labori, Kristoffer Lassen, Bård I. Røsok, Jon A. Søreide, Tore Tholfsen, Olaug Villanger & Anne Waage
  • Background Colorectal cancer is one the most common cancers in the western world with increasing incidence. Approximately 50% of the patients develop liver metastases. Resection of liver metastases is the treatment of choice although almost half of the resected patients get recurrence in the liver. Methods The ASAC trial is a Scandinavian, multicentre, double-blinded, randomized, placebo-controlled study to determine whether adjuvant treatment with low-dose aspirin (acetylsalicylic acid (ASA)) can improve disease-free survival in patients treated for colorectal cancer liver metastases (CRCLM). Up to 800 patients operated for CRCLM will be randomized to Arm#1 ASA 160 mg once daily or Arm#2 Placebo, for a period of 3 years or until disease recurrence. The patients will be recruited at all major hepatobiliary surgical units in Norway, Sweden and Denmark and have follow-up according to standard of care and the National Guidelines. Discussion The ASAC trial will be the first clinical interventional trial to assess the potential beneficial role of ASA in recurrence of CRCLM and survival. ASA is an inexpensive, well-tolerated and easily accessible drug that will be highly potential as adjuvant drug in secondary prevention of CRCLM if the study shows a beneficial effect. We will also determine the effect of ASA as adjuvant treatment on Health-Related Quality of Life and the cost-effectiveness.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Bjornbeth, B. A.Department of Hepato-Pancreato-Biliary Surgery, Oslo University Hospital, Oslo, Norway,Oslo Univ Hosp, Dept Hepato Pancreato Biliary Surg, Oslo, Norway. (author)
  • Angelsen, J. H.Department of Acute and Digestive Surgery, Haukeland University Hospital, Bergen, Norway; Departments of Clinical Medicine, University of Bergen, Bergen, Norway,Haukeland Hosp, Dept Acute & Digest Surg, Bergen, Norway.;Univ Bergen, Dept Clin Med, Bergen, Norway. (author)
  • Fristrup, C. W.Department of Surgery, Odense University Hospital, Odense C, Denmark,Odense Univ Hosp, Dept Surg, Odense C, Denmark. (author)
  • Gronbech, J. E.Department of Gastrointestinal Surgery, St. Olav’s Hospital, Trondheim University Hospital, Trondheim, Norway; Department of Clinical and Molecular Medicine, NTNU, Norwegian University of Science and Technology, Trondheim, Norway,Univ Trondheim Hosp, St Olavs Hosp, Dept Gastrointestinal Surg, Trondheim, Norway.;Norwegian Univ Sci & Technol, Dept Clin & Mol Med, NTNU, Trondheim, Norway. (author)
  • Hemmingsson, Oskar,1975-Umeå universitet,Kirurgi,Department of Surgical and Perioperative Sciences, Umeå University, Umea, Sweden,Umeå Univ, Dept Surg & Perioperat Sci, Umeå, Sweden.(Swepub:umu)osrhen96 (author)
  • Isaksson, BengtUppsala universitet,Gastrointestinalkirurgi(Swepub:uu)benis326 (author)
  • Juel, I. S.Department of Gastrointestinal Surgery, St. Olav’s Hospital, Trondheim University Hospital, Trondheim, Norway,Univ Trondheim Hosp, St Olavs Hosp, Dept Gastrointestinal Surg, Trondheim, Norway. (author)
  • Larsen, P. N.Department of Gastrointestinal Surgery, Rigshospitalet, Copenhagen, Denmark,Rigshosp, Dept Gastrointestinal Surg, Copenhagen, Denmark. (author)
  • Lindell, G.Department of Surgery, Skåne University Hospital, Lund, Sweden,Skane Univ Hosp, Dept Surg, Lund, Sweden. (author)
  • Mortensen, F. V.Department of Surgery, Aarhus University Hospital, Aarhus N, Denmark,Aarhus Univ Hosp, Dept Surg, Aarhus N, Denmark. (author)
  • Mortensen, K. E.Department of Gastrointestinal Surgery, University Hospital of North, Tromsø, Norway,Univ Hosp North, Dept Gastrointestinal Surg, Tromso, Norway. (author)
  • Rizell, Magnus,1963Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery,Department of Transplantation, Institute of Clinical Sciences, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden,Univ Gothenburg, Sahlgrenska Univ Hosp, Inst Clin Sci, Dept Transplantat, Gothenburg, Sweden.(Swepub:gu)xrizma (author)
  • Sandström, Per A,1965-Linköpings universitet,Medicinska fakulteten,Avdelningen för kirurgi, ortopedi och onkologi,Region Östergötland, Kirurgiska kliniken US,Cty Council Ostergotland, Dept Surg, Linköping, Sweden.;Div Surg, Dept Biomed & Clin Sci Orthoped & Oncol, Linköping, Sweden.(Swepub:liu)persa07 (author)
  • Sandvik, O. M.Department of Gastrointestinal Surgery, Stavanger University Hospital, Stavanger, Norway,Stavanger Univ Hosp, Dept Gastrointestinal Surg, Stavanger, Norway. (author)
  • Sparrelid, E.Karolinska Institutet (author)
  • Taflin, HelenaGothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery,Department of Surgery, Institute of Clinical Sciences, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden,Univ Gothenburg, Sahlgrenska Univ Hosp, Inst Clin Sci, Dept Surg, Gothenburg, Sweden.(Swepub:gu)xtafhe (author)
  • Tasken, K.Institute for Cancer Research, Oslo University Hospital, and Institute of Clinical Medicine, University of Oslo, Oslo, Norway,Department of Hepato-Pancreato-Biliary Surgery, Oslo University Hospital, Oslo, Norway,Oslo Univ Hosp, Inst Canc Res, Oslo, Norway.;Univ Oslo, Inst Clin Med, Oslo, Norway. (author)
  • Brudvik, Kristoffer W.Department of Hepato-Pancreato-Biliary Surgery, Oslo University Hospital, Oslo, Norway (author)
  • Fretland, Åsmund A.Department of Hepato-Pancreato-Biliary Surgery, Oslo University Hospital, Oslo, Norway (author)
  • Horn, ArildDepartment of Acute and Digestive Surgery, Haukeland University Hospital, Bergen, Norway; Departments of Clinical Medicine, University of Bergen, Bergen, Norway (author)
  • Kleive, DyreDepartment of Hepato-Pancreato-Biliary Surgery, Oslo University Hospital, Oslo, Norway (author)
  • Labori, Knut J.Department of Hepato-Pancreato-Biliary Surgery, Oslo University Hospital, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway (author)
  • Søreide, Jon A.Department of Gastrointestinal Surgery, Stavanger University Hospital, Stavanger, Norway (author)
  • Tholfsen, ToreDepartment of Hepato-Pancreato-Biliary Surgery, Oslo University Hospital, Oslo, Norway (author)
  • Villanger, OlaugDepartment of Hepato-Pancreato-Biliary Surgery, Oslo University Hospital, Oslo, Norway (author)
  • Waage, AnneDepartment of Hepato-Pancreato-Biliary Surgery, Oslo University Hospital, Oslo, Norway (author)
  • Department of Hepato-Pancreato-Biliary Surgery, Oslo University Hospital, Oslo, Norway. shya@ous-hf.no; Institute of Clinical Medicine, University of Oslo, Oslo, NorwayOslo Univ Hosp, Dept Hepato Pancreato Biliary Surg, Oslo, Norway.;Univ Oslo, Inst Clin Med, Oslo, Norway. (creator_code:org_t)

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  • In:TrialsLondon, United Kingdom : Springer Science and Business Media LLC22:11745-6215

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