Method and Clinical Validation of Biomarkers for Neurodegenerative Diseases

• In the Merriam-Webster dictionary, one definition of the word valid is “well-grounded or justifiable: being at once relevant and meaningful.” Validation is then the process of determining the degree of validity. From this broad definition, it follows that validations can be made in many different fields with quite different implications. When talking about validation, it is therefore important to specify the subject under scrutiny and in this chapter the focus will be on validation of biomarkers. © 2021, Springer Science+Business Media, LLC, part of Springer Nature.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Neurosciences (hsv//eng)

Nyckelord

Biomarker

Cut-point

Neurodegeneration

Validation

degenerative disease

diagnostic accuracy

Food and Drug Administration

human

measurement precision

nerve degeneration

predictive value

priority journal

process optimization

quality control

sensitivity and specificity

validation process

Publikations- och innehållstyp

vet (ämneskategori)

kap (ämneskategori)