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Whole-genome charac...
Whole-genome characterization of hemolytic uremic syndrome-causing Shiga toxin-producing Escherichia coli in Sweden
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- Hua, Y. (författare)
- Southern Med Univ, Peoples R China; Karolinska Inst, Sweden
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- Chromek, M. (författare)
- Karolinska Institutet
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- Frykman, Anne, 1983 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics,Sahlgrens Univ Hosp, Sweden; Univ Gothenburg, Sweden
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- Jernberg, C. (författare)
- Publ Hlth Agcy Sweden, Sweden
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- Georgieva, V. (författare)
- Division of Pediatrics, Department of Clinical Science, Intervention and Technology, Karolinska Institutet; Karolinska University Hospital, Stockholm, Sweden
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- Hansson, Sverker, 1946 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics,Sahlgrens Univ Hosp, Sweden; Univ Gothenburg, Sweden
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- Zhang, J. (författare)
- Massey Univ, New Zealand
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- Marits, A. K. (författare)
- Karolinska Inst, Sweden
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- Wan, C. (författare)
- Southern Med Univ, Peoples R China
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- Matussek, Andreas (författare)
- Karolinska Institutet,Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Karolinska Inst, Sweden; Oslo Univ Hosp, Norway; Univ Oslo, Norway
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- Bai, X. (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2021-05-03
- 2021
- Engelska.
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Ingår i: Virulence. - : Informa UK Limited. - 2150-5594 .- 2150-5608. ; 12:1, s. 1296-1305
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Abstract
Ämnesord
Stäng
- Shiga toxin-producing Escherichia coli, a foodborne bacterial pathogen, has been linked to a broad spectrum of clinical outcomes ranging from asymptomatic carriage to fatal hemolytic uremic syndrome (HUS). Here, we collected clinical data and STEC strains from HUS patients from 1994 through 2018, whole-genome sequencing was performed to molecularly characterize HUS-associated STEC strains, statistical analysis was conducted to identify bacterial genetic factors associated with severe outcomes in HUS patients. O157:H7 was the most predominant serotype (57%) among 54 HUS-associated STEC strains, followed by O121:H19 (19%) and O26:H11 (7%). Notably, some non-predominant serotypes such as O59:H17 (2%) and O109:H21 (2%) also caused HUS. All O157:H7 strains with one exception belonged to clade 8. During follow-up at a median of 4years, 41% of the patients had renal sequelae. Fifty-nine virulence genes were found to be statistically associated with severe renal sequelae, these genes encoded type II and type III secretion system effectors, chaperones, and other factors. Notably, virulence genes associated with severe clinical outcomes were significantly more prevalent in O157:H7 strains. In contrast, genes related to mild symptoms were evenly distributed across all serotypes. The whole-genome phylogeny indicated high genomic diversity among HUS-STEC strains. No distinct cluster was found between HUS and non-HUS STEC strains. The current study showed that O157:H7 remains the main cause of STEC-associated HUS, despite the rising importance of other non-O157 serotypes. Besides, O157:H7 is associated with severe renal sequelae in the follow-up, which could be a risk factor for long-term prognosis in HUS patients. © 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Nyckelord
- clinical outcomes
- hemolytic uremic syndrome
- O157:H7
- Shiga toxin-producing Escherichia coli
- virulence genes
- whole-genome sequencing
- Shiga toxin-producing Escherichia coli; hemolytic uremic syndrome; clinical outcomes; O157; H7; virulence genes; whole-genome sequencing
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Hua, Y.
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Chromek, M.
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Frykman, Anne, 1 ...
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Jernberg, C.
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Georgieva, V.
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Hansson, Sverker ...
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visa fler...
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Zhang, J.
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Marits, A. K.
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Wan, C.
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Matussek, Andrea ...
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Bai, X.
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- Om ämnet
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- Artiklar i publikationen
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Virulence
- Av lärosätet
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Göteborgs universitet
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Linköpings universitet
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Karolinska Institutet