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Four distinct traje...
Four distinct trajectories of tau deposition identified in Alzheimer’s disease
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- Vogel, Jacob W. (author)
- McGill University
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- Young, A. L. (author)
- King's College London
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- Oxtoby, N. P. (author)
- University College London
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show more...
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- Smith, Ruben (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital
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- Ossenkoppele, Rik (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Academic Medical Center of University of Amsterdam (AMC),Vrije Universiteit Amsterdam
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- Strandberg, Olof T. (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups
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- La Joie, R. (author)
- University of California, San Francisco
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- Aksman, L. M. (author)
- University College London
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- Grothe, Michel J., 1981 (author)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Wallenberg Centre for Molecular and Translational Medicine
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- Iturria-Medina, Y. (author)
- McGill University
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Weiner, M. (author)
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Aisen, P. (author)
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Petersen, R. (author)
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- Jack, Jr. (author)
- Avid Radiopharmaceuticals, Inc
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Jagust, W. (author)
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Trojanowki, J. Q. (author)
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Toga, A. W. (author)
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Beckett, L. (author)
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Green, R. C. (author)
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Saykin, A. J. (author)
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Morris, J. (author)
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Shaw, L. M. (author)
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Liu, E. (author)
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Montine, T. (author)
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Thomas, R. G. (author)
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- Donohue, M. (author)
- Avid Radiopharmaceuticals, Inc
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Walter, S. (author)
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Gessert, D. (author)
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Sather, T. (author)
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Jiminez, G. (author)
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Harvey, D. (author)
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Bernstein, M. (author)
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Fox, N. (author)
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Thompson, P. (author)
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Schuff, N. (author)
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DeCarli, C. (author)
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Borowski, B. (author)
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Gunter, J. (author)
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Senjem, M. (author)
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Vemuri, P. (author)
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Jones, D. (author)
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Kantarci, K. (author)
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Ward, C. (author)
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Koeppe, R. A. (author)
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Foster, N. (author)
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Reiman, E. M. (author)
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Chen, K. (author)
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Mathis, C. (author)
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Landau, S. (author)
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Cairns, N. J. (author)
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Householder, E. (author)
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Reinwald, L. T. (author)
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Lee, V. (author)
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Korecka, M. (author)
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Figurski, M. (author)
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Crawford, K. (author)
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Neu, S. (author)
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Foroud, T. M. (author)
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Potkin, S. (author)
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Shen, L. (author)
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Kelley, F. (author)
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Kim, S. (author)
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Nho, K. (author)
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Kachaturian, Z. (author)
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Frank, R. (author)
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Snyder, P. J. (author)
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Molchan, S. (author)
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Kaye, J. (author)
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Quinn, J. (author)
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Lind, B. (author)
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Carter, R. (author)
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Dolen, S. (author)
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Schneider, L. S. (author)
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Pawluczyk, S. (author)
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Beccera, M. (author)
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Teodoro, L. (author)
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Spann, B. M. (author)
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Brewer, J. (author)
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Vanderswag, H. (author)
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Fleisher, A. (author)
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Heidebrink, J. L. (author)
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Lord, J. L. (author)
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Mason, S. S. (author)
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Albers, C. S. (author)
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Knopman, D. (author)
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Johnson, K. (author)
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Doody, R. S. (author)
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Meyer, J. V. (author)
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Chowdhury, M. (author)
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Rountree, S. (author)
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Dang, M. (author)
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Stern, Y. (author)
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Honig, L. S. (author)
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Bell, K. L. (author)
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Ances, B. (author)
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Morris, J. C. (author)
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Carroll, M. (author)
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Leon, S. (author)
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Mintun, M. A. (author)
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Schneider, S. (author)
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Oliver, A. (author)
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Griffith, R. (author)
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- Clark, D. (author)
- University College London
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Geldmacher, D. (author)
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Brockington, J. (author)
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Roberson, E. (author)
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Grossman, H. (author)
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Mitsis, E. (author)
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deToledo-Morrell, L. (author)
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Shah, R. C. (author)
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- Duara, R. (author)
- University of California, San Francisco
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Varon, D. (author)
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Greig, M. T. (author)
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Roberts, P. (author)
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Albert, M. (author)
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Onyike, C. (author)
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D’Agostino, II (author)
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Kielb, S. (author)
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Galvin, J. E. (author)
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Pogorelec, D. M. (author)
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Cerbone, B. (author)
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Michel, C. A. (author)
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Rusinek, H. (author)
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de Leon, M. J. (author)
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Glodzik, L. (author)
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De Santi, S. (author)
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Doraiswamy, P. M. (author)
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Petrella, J. R. (author)
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Wong, T. Z. (author)
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Arnold, S. E. (author)
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Karlawish, J. H. (author)
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Wolk, D. (author)
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Smith, C. D. (author)
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Jicha, G. (author)
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Hardy, P. (author)
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Sinha, P. (author)
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Oates, E. (author)
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Conrad, G. (author)
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Lopez, O. L. (author)
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Oakley, M. A. (author)
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Simpson, D. M. (author)
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Porsteinsson, A. P. (author)
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Goldstein, B. S. (author)
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Martin, K. (author)
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Makino, K. M. (author)
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Ismail, M. S. (author)
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Brand, C. (author)
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Mulnard, R. A. (author)
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Thai, G. (author)
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McAdams Ortiz, C. (author)
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Womack, K. (author)
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Mathews, D. (author)
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Quiceno, M. (author)
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Arrastia, R. D. (author)
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King, R. (author)
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Weiner, M. (author)
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Cook, K. M. (author)
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DeVous, M. (author)
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Levey, A. I. (author)
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Lah, J. J. (author)
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Cellar, J. S. (author)
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Burns, J. M. (author)
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Anderson, H. S. (author)
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Swerdlow, R. H. (author)
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Apostolova, L. (author)
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Tingus, K. (author)
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Woo, E. (author)
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Silverman, D. H. S. (author)
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Lu, P. H. (author)
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Bartzokis, G. (author)
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Radford, N. R. G. (author)
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Parfitt, F. (author)
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Kendall, T. (author)
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Johnson, H. (author)
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Farlow, M. R. (author)
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Hake, A. M. (author)
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Matthews, B. R. (author)
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Herring, S. (author)
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Hunt, C. (author)
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van Dyck, C. H. (author)
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Carson, R. E. (author)
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MacAvoy, M. G. (author)
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Chertkow, H. (author)
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Bergman, H. (author)
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Hosein, C. (author)
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Black, S. (author)
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Stefanovic, B. (author)
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- Caldwell, C. (author)
- McGill University
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Hsiung, G. Y. R. (author)
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Feldman, H. (author)
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Mudge, B. (author)
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Past, M. A. (author)
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Kertesz, A. (author)
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Rogers, J. (author)
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Trost, D. (author)
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Bernick, C. (author)
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Munic, D. (author)
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Kerwin, D. (author)
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Mesulam, M. M. (author)
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Lipowski, K. (author)
-
Wu, C. K. (author)
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Johnson, N. (author)
-
Sadowsky, C. (author)
-
Martinez, W. (author)
-
Villena, T. (author)
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Turner, R. S. (author)
-
Johnson, K. (author)
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Reynolds, B. (author)
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Sperling, R. A. (author)
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Johnson, K. A. (author)
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Marshall, G. (author)
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Frey, M. (author)
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Yesavage, J. (author)
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Taylor, J. L. (author)
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Lane, B. (author)
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Rosen, A. (author)
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Tinklenberg, J. (author)
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Sabbagh, M. N. (author)
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Belden, C. M. (author)
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Jacobson, S. A. (author)
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Sirrel, S. A. (author)
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Kowall, N. (author)
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Killiany, R. (author)
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Budson, A. E. (author)
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Norbash, A. (author)
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Johnson, P. L. (author)
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Obisesan, T. O. (author)
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Wolday, S. (author)
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Allard, J. (author)
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Lerner, A. (author)
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Ogrocki, P. (author)
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Hudson, L. (author)
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Fletcher, E. (author)
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Carmichael, O. (author)
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Olichney, J. (author)
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DeCarli, C. (author)
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Kittur, S. (author)
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Borrie, M. (author)
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Lee, T. Y. (author)
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Bartha, R. (author)
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Johnson, S. (author)
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Asthana, S. (author)
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Carlsson, C. M. (author)
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Potkin, S. G. (author)
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Preda, A. (author)
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Nguyen, D. (author)
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Tariot, P. (author)
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Reeder, S. (author)
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Bates, V. (author)
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Capote, H. (author)
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Rainka, M. (author)
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Scharre, D. W. (author)
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Kataki, M. (author)
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Adeli, A. (author)
-
Zimmerman, E. A. (author)
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Celmins, D. (author)
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Brown, A. D. (author)
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Pearlson, G. D. (author)
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Blank, K. (author)
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Anderson, K. (author)
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Santulli, R. B. (author)
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Kitzmiller, T. J. (author)
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Schwartz, E. S. (author)
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Sink, K. M. (author)
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Williamson, J. D. (author)
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Garg, P. (author)
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Watkins, F. (author)
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Ott, B. R. (author)
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Querfurth, H. (author)
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Tremont, G. (author)
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Salloway, S. (author)
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Malloy, P. (author)
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Correia, S. (author)
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Rosen, H. J. (author)
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Miller, B. L. (author)
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Mintzer, J. (author)
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Spicer, K. (author)
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Bachman, D. (author)
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Finger, E. (author)
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Pasternak, S. (author)
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Rachinsky, I. (author)
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Drost, D. (author)
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Pomara, N. (author)
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Hernando, R. (author)
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Sarrael, A. (author)
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Schultz, S. K. (author)
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Ponto, L. L. B. (author)
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Shim, H. (author)
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Smith, K. E. (author)
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Relkin, N. (author)
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Chaing, G. (author)
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Raudin, L. (author)
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Smith, A. (author)
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Fargher, K. (author)
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Raj, B. A. (author)
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Pontecorvo, M. J. (author)
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Devous, M. D. (author)
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Rabinovici, G. D. (author)
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Alexander, D. C. (author)
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- Lyoo, C. H. (author)
- Yonsei University
-
Evans, A. C. (author)
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- Hansson, Oskar (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital
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show less...
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(creator_code:org_t)
- 2021-04-29
- 2021
- English.
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In: Nature Medicine. - : Springer Science and Business Media LLC. - 1078-8956 .- 1546-170X. ; 27:5, s. 871-881
- Related links:
-
https://www.ncbi.nlm...
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show more...
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http://dx.doi.org/10...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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show less...
Abstract
Subject headings
Close
- Alzheimer’s disease (AD) is characterized by the spread of tau pathology throughout the cerebral cortex. This spreading pattern was thought to be fairly consistent across individuals, although recent work has demonstrated substantial variability in the population with AD. Using tau-positron emission tomography scans from 1,612 individuals, we identified 4 distinct spatiotemporal trajectories of tau pathology, ranging in prevalence from 18 to 33%. We replicated previously described limbic-predominant and medial temporal lobe-sparing patterns, while also discovering posterior and lateral temporal patterns resembling atypical clinical variants of AD. These ‘subtypes’ were stable during longitudinal follow-up and were replicated in a separate sample using a different radiotracer. The subtypes presented with distinct demographic and cognitive profiles and differing longitudinal outcomes. Additionally, network diffusion models implied that pathology originates and spreads through distinct corticolimbic networks in the different subtypes. Together, our results suggest that variation in tau pathology is common and systematic, perhaps warranting a re-examination of the notion of ‘typical AD’ and a revisiting of tau pathological staging. © 2021, The Author(s), under exclusive licence to Springer Nature America, Inc.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
-
Vogel, Jacob W.
-
Young, A. L.
-
Oxtoby, N. P.
-
Smith, Ruben
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Ossenkoppele, Ri ...
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Strandberg, Olof ...
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show more...
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La Joie, R.
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Aksman, L. M.
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Grothe, Michel J ...
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Iturria-Medina, ...
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Weiner, M.
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Aisen, P.
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Petersen, R.
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Jack, Jr.
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Jagust, W.
-
Trojanowki, J. Q ...
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Toga, A. W.
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Beckett, L.
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Green, R. C.
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Saykin, A. J.
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Morris, J.
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Shaw, L. M.
-
Liu, E.
-
Montine, T.
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Thomas, R. G.
-
Donohue, M.
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Walter, S.
-
Gessert, D.
-
Sather, T.
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Jiminez, G.
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Harvey, D.
-
Bernstein, M.
-
Fox, N.
-
Thompson, P.
-
Schuff, N.
-
DeCarli, C.
-
Borowski, B.
-
Gunter, J.
-
Senjem, M.
-
Vemuri, P.
-
Jones, D.
-
Kantarci, K.
-
Ward, C.
-
Koeppe, R. A.
-
Foster, N.
-
Reiman, E. M.
-
Chen, K.
-
Mathis, C.
-
Landau, S.
-
Cairns, N. J.
-
Householder, E.
-
Reinwald, L. T.
-
Lee, V.
-
Korecka, M.
-
Figurski, M.
-
Crawford, K.
-
Neu, S.
-
Foroud, T. M.
-
Potkin, S.
-
Shen, L.
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Kelley, F.
-
Kim, S.
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Nho, K.
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Kachaturian, Z.
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Frank, R.
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Snyder, P. J.
-
Molchan, S.
-
Kaye, J.
-
Quinn, J.
-
Lind, B.
-
Carter, R.
-
Dolen, S.
-
Schneider, L. S.
-
Pawluczyk, S.
-
Beccera, M.
-
Teodoro, L.
-
Spann, B. M.
-
Brewer, J.
-
Vanderswag, H.
-
Fleisher, A.
-
Heidebrink, J. L ...
-
Lord, J. L.
-
Mason, S. S.
-
Albers, C. S.
-
Knopman, D.
-
Johnson, K.
-
Doody, R. S.
-
Meyer, J. V.
-
Chowdhury, M.
-
Rountree, S.
-
Dang, M.
-
Stern, Y.
-
Honig, L. S.
-
Bell, K. L.
-
Ances, B.
-
Morris, J. C.
-
Carroll, M.
-
Leon, S.
-
Mintun, M. A.
-
Schneider, S.
-
Oliver, A.
-
Griffith, R.
-
Clark, D.
-
Geldmacher, D.
-
Brockington, J.
-
Roberson, E.
-
Grossman, H.
-
Mitsis, E.
-
deToledo-Morrell ...
-
Shah, R. C.
-
Duara, R.
-
Varon, D.
-
Greig, M. T.
-
Roberts, P.
-
Albert, M.
-
Onyike, C.
-
D’Agostino, II
-
Kielb, S.
-
Galvin, J. E.
-
Pogorelec, D. M.
-
Cerbone, B.
-
Michel, C. A.
-
Rusinek, H.
-
de Leon, M. J.
-
Glodzik, L.
-
De Santi, S.
-
Doraiswamy, P. M ...
-
Petrella, J. R.
-
Wong, T. Z.
-
Arnold, S. E.
-
Karlawish, J. H.
-
Wolk, D.
-
Smith, C. D.
-
Jicha, G.
-
Hardy, P.
-
Sinha, P.
-
Oates, E.
-
Conrad, G.
-
Lopez, O. L.
-
Oakley, M. A.
-
Simpson, D. M.
-
Porsteinsson, A. ...
-
Goldstein, B. S.
-
Martin, K.
-
Makino, K. M.
-
Ismail, M. S.
-
Brand, C.
-
Mulnard, R. A.
-
Thai, G.
-
McAdams Ortiz, C ...
-
Womack, K.
-
Mathews, D.
-
Quiceno, M.
-
Arrastia, R. D.
-
King, R.
-
Cook, K. M.
-
DeVous, M.
-
Levey, A. I.
-
Lah, J. J.
-
Cellar, J. S.
-
Burns, J. M.
-
Anderson, H. S.
-
Swerdlow, R. H.
-
Apostolova, L.
-
Tingus, K.
-
Woo, E.
-
Silverman, D. H. ...
-
Lu, P. H.
-
Bartzokis, G.
-
Radford, N. R. G ...
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Parfitt, F.
-
Kendall, T.
-
Johnson, H.
-
Farlow, M. R.
-
Hake, A. M.
-
Matthews, B. R.
-
Herring, S.
-
Hunt, C.
-
van Dyck, C. H.
-
Carson, R. E.
-
MacAvoy, M. G.
-
Chertkow, H.
-
Bergman, H.
-
Hosein, C.
-
Black, S.
-
Stefanovic, B.
-
Caldwell, C.
-
Hsiung, G. Y. R.
-
Feldman, H.
-
Mudge, B.
-
Past, M. A.
-
Kertesz, A.
-
Rogers, J.
-
Trost, D.
-
Bernick, C.
-
Munic, D.
-
Kerwin, D.
-
Mesulam, M. M.
-
Lipowski, K.
-
Wu, C. K.
-
Johnson, N.
-
Sadowsky, C.
-
Martinez, W.
-
Villena, T.
-
Turner, R. S.
-
Reynolds, B.
-
Sperling, R. A.
-
Johnson, K. A.
-
Marshall, G.
-
Frey, M.
-
Yesavage, J.
-
Taylor, J. L.
-
Lane, B.
-
Rosen, A.
-
Tinklenberg, J.
-
Sabbagh, M. N.
-
Belden, C. M.
-
Jacobson, S. A.
-
Sirrel, S. A.
-
Kowall, N.
-
Killiany, R.
-
Budson, A. E.
-
Norbash, A.
-
Johnson, P. L.
-
Obisesan, T. O.
-
Wolday, S.
-
Allard, J.
-
Lerner, A.
-
Ogrocki, P.
-
Hudson, L.
-
Fletcher, E.
-
Carmichael, O.
-
Olichney, J.
-
Kittur, S.
-
Borrie, M.
-
Lee, T. Y.
-
Bartha, R.
-
Johnson, S.
-
Asthana, S.
-
Carlsson, C. M.
-
Potkin, S. G.
-
Preda, A.
-
Nguyen, D.
-
Tariot, P.
-
Reeder, S.
-
Bates, V.
-
Capote, H.
-
Rainka, M.
-
Scharre, D. W.
-
Kataki, M.
-
Adeli, A.
-
Zimmerman, E. A.
-
Celmins, D.
-
Brown, A. D.
-
Pearlson, G. D.
-
Blank, K.
-
Anderson, K.
-
Santulli, R. B.
-
Kitzmiller, T. J ...
-
Schwartz, E. S.
-
Sink, K. M.
-
Williamson, J. D ...
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Garg, P.
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Watkins, F.
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Ott, B. R.
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Querfurth, H.
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Tremont, G.
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Salloway, S.
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Malloy, P.
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Correia, S.
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Rosen, H. J.
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Miller, B. L.
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Mintzer, J.
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Spicer, K.
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Bachman, D.
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Finger, E.
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Pasternak, S.
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Rachinsky, I.
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Drost, D.
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Pomara, N.
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Hernando, R.
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Sarrael, A.
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Schultz, S. K.
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Ponto, L. L. B.
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Shim, H.
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Smith, K. E.
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Relkin, N.
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Chaing, G.
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Raudin, L.
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Smith, A.
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Fargher, K.
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Raj, B. A.
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Pontecorvo, M. J ...
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Devous, M. D.
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Rabinovici, G. D ...
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Alexander, D. C.
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Lyoo, C. H.
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Evans, A. C.
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Hansson, Oskar
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Nature Medicine
- By the university
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University of Gothenburg
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Lund University