Uniting biobank resources reveals novel genetic pathways modulating susceptibility for atopic dermatitis

Background: Atopic dermatitis (AD) is a common chronic inflammatory skin disease with high heritability. Previous genome-wide association studies have identified several loci predisposing to AD. These findings explain approximately 30% of the variance in AD susceptibility, suggesting that further work is required to fully understand the genetic underpinnings. Objective: We sought to gain additional understanding of the genetic contribution to AD risk by using biobank resources. Methods: We completed a genome-wide meta-analysis of AD in 796,661 individuals (Ncases = 22,474) from the FinnGen study, the Estonian Biobank, and the UK Biobank. We further performed downstream in silico analyses to characterize the risk variants at the novel loci. Results: We report 30 loci associating with AD (P < 5 × 10−8), 5 of which are novel. In 2 of the novel loci, we identified missense mutations with deleterious predictions in desmocollin 1 and serpin family B member 7, genes encoding proteins crucial to epidermal strength and integrity. Conclusions: These findings elucidate novel genetic pathways involved in AD pathophysiology. The likely involvement of desmocollin 1 and serpin family B member 7 in AD pathogenesis may offer opportunities for the development of novel treatment strategies for AD in the future.

Huilaja, Laura (author)
Pasanen, Anu (author)
Laisk, Triin (author)
Reimann, Ene (author)
Mägi, Reedik (author)
Hannula-Jouppi, Katariina (author)
Peltonen, Sirkku,1964Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för dermatologi och venereologi,Institute of Clinical Sciences, Department of Dermatology and Venereology(Swepub:gu)xpelsi (author)
Salmi, Teea (author)
Koulu, Leena (author)
Tasanen, Kaisa (author)
Kettunen, Johannes (author)
Göteborgs universitetInstitutionen för kliniska vetenskaper, Avdelningen för dermatologi och venereologi (creator_code:org_t)

In:Journal of Allergy and Clinical Immunology: Elsevier BV149:30091-67491097-6825

By the author/editor: Sliz, Eeva; Huilaja, Laura; Pasanen, Anu; Laisk, Triin; Reimann, Ene; Mägi, Reedik; show more...; Hannula-Jouppi, ...; Peltonen, Sirkku ...; Salmi, Teea; Koulu, Leena; Tasanen, Kaisa; Kettunen, Johann ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Dermatology and ...

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