Sökning: WFRF:(Larson Göran 1953) >
Physicochemical too...
Physicochemical tools for studying virus interactions with targeted cell membranes in a molecular and spatiotemporally resolved context
-
- Bally, Marta, 1981 (författare)
- Umeå universitet,Institutionen för klinisk mikrobiologi,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM)
-
- Block, Stephan, 1978 (författare)
- Freie Universität Berlin,Department of Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany
-
- Höök, Fredrik, 1966 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology,Department of Physics, Chalmers University of Technology, Gothenburg, Sweden
-
visa fler...
-
- Larson, Göran, 1953 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Department of Laboratory Medicine,Sahlgrenska universitetssjukhuset,Sahlgrenska University Hospital,Department of Laboratory Medicine, Sahlgrenska Academy at the University of Gothenburg, Sahlgrenska University Hospital, Bruna Stråket 16, Gothenburg, Sweden
-
- Parveen, Nagma, 1988 (författare)
- Indian Institute of Technology,Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur, India
-
- Rydell, Gustaf E (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,University of Gothenburg,Department of Infectious Diseases, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
-
visa färre...
-
(creator_code:org_t)
- 2021-09-07
- 2021
- Engelska.
-
Ingår i: Analytical and Bioanalytical Chemistry. - : Springer Science and Business Media LLC. - 1618-2642 .- 1618-2650. ; 413, s. 7157-7178
- Relaterad länk:
-
https://link.springe...
-
visa fler...
-
https://research.cha... (primary) (free)
-
https://doi.org/10.1...
-
https://umu.diva-por... (primary) (Raw object)
-
https://gup.ub.gu.se...
-
https://doi.org/10.1...
-
https://research.cha...
-
https://urn.kb.se/re...
-
visa färre...
Abstract
Ämnesord
Stäng
- The objective of this critical review is to provide an overview of how emerging bioanalytical techniques are expanding our understanding of the complex physicochemical nature of virus interactions with host cell surfaces. Herein, selected model viruses representing both non-enveloped (simian virus 40 and human norovirus) and enveloped (influenza A virus, human herpes simplex virus, and human immunodeficiency virus type 1) viruses are highlighted. The technologies covered utilize a wide range of cell membrane mimics, from supported lipid bilayers (SLBs) containing a single purified host membrane component to SLBs derived from the plasma membrane of a target cell, which can be compared with live-cell experiments to better understand the role of individual interaction pairs in virus attachment and entry. These platforms are used to quantify binding strengths, residence times, diffusion characteristics, and binding kinetics down to the single virus particle and single receptor, and even to provide assessments of multivalent interactions. The technologies covered herein are surface plasmon resonance (SPR), quartz crystal microbalance with dissipation (QCM-D), dynamic force spectroscopy (DFS), total internal reflection fluorescence (TIRF) microscopy combined with equilibrium fluctuation analysis (EFA) and single particle tracking (SPT), and finally confocal microscopy using multi-labeling techniques to visualize entry of individual virus particles in live cells. Considering the growing scientific and societal needs for untangling, and interfering with, the complex mechanisms of virus binding and entry, we hope that this review will stimulate the community to implement these emerging tools and strategies in conjunction with more traditional methods. The gained knowledge will not only contribute to a better understanding of the virus biology, but may also facilitate the design of effective inhibitors to block virus entry.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Andra medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Other Basic Medicine (hsv//eng)
- NATURVETENSKAP -- Biologi -- Biofysik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biophysics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Nyckelord
- Virus protein to host membrane interactions
- Quartz crystal microbalance
- with dissipation
- Dynamic force spectroscopy
- Total internal reflection
- fluorescence microscopy
- Equilibrium fluctuation analysis
- Single
- particle tracking
- herpes-simplex-virus
- quartz-crystal microbalance
- receptor-binding
- specificity
- surface-plasmon resonance
- murine polyoma-virus
- single-particle
- heparan-sulfate
- influenza-viruses
- gm1 ganglioside
- glycoprotein-c
- Biochemistry & Molecular Biology
- Chemistry
- Equilibrium fluctuation analysis
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Bally, Marta, 19 ...
-
Block, Stephan, ...
-
Höök, Fredrik, 1 ...
-
Larson, Göran, 1 ...
-
Parveen, Nagma, ...
-
Rydell, Gustaf E
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Medicinska och f ...
-
och Cell och molekyl ...
-
- NATURVETENSKAP
-
NATURVETENSKAP
-
och Biologi
-
och Cellbiologi
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Medicinska och f ...
-
och Andra medicinska ...
-
- NATURVETENSKAP
-
NATURVETENSKAP
-
och Biologi
-
och Biofysik
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Medicinska och f ...
-
och Mikrobiologi ino ...
- Artiklar i publikationen
-
Analytical and B ...
- Av lärosätet
-
Göteborgs universitet
-
Chalmers tekniska högskola
-
Umeå universitet