Search: WFRF:(Lill Christina M.) >
A common polymorphi...
A common polymorphism in the dopamine transporter gene predicts working memory performance and in vivo dopamine integrity in aging
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- Karalija, Nina, 1984- (author)
- Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Diagnostisk radiologi,Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany
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- Köhncke, Ylva (author)
- Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany
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- Düzel, Sandra (author)
- Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany
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- Bertram, Lars (author)
- Lübeck Interdisciplinary Platform for Genome Analytics, University of Lübeck, Lübeck, Germany; Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway
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- Papenberg, Goran (author)
- Karolinska Institutet
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- Demuth, Ilja (author)
- Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Endocrinology and Metabolism, Berlin, Germany; Charité – Universitätsmedizin Berlin, BCRT - Berlin Institute of Health Center for Regenerative Therapies, Berlin, Germany
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- Lill, Christina M. (author)
- Lübeck Interdisciplinary Platform for Genome Analytics, University of Lübeck, Lübeck, Germany; Ageing Epidemiology Research Unit, School of Public Health, Imperial College London, UK, London, United Kingdom
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- Johansson, Jarkko (author)
- Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Diagnostisk radiologi
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- Riklund, Katrine, MD, PhD, Professor, 1963- (author)
- Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Diagnostisk radiologi
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- Lövdén, Martin, 1972 (author)
- Karolinska Institutet,Gothenburg University,Göteborgs universitet,Psykologiska institutionen,Department of Psychology,Department of psychology, University of Gothenburg, Gothenburg, Sweden
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- Bäckman, Lars (author)
- Karolinska Institutet
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- Nyberg, Lars, 1966- (author)
- Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Institutionen för integrativ medicinsk biologi (IMB),Diagnostisk radiologi
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- Lindenberger, Ulman (author)
- Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany; Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Berlin, Germany, and, UK, London, United Kingdom
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- Brandmaier, Andreas M. (author)
- Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany; Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Berlin, Germany, and, UK, London, United Kingdom
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(creator_code:org_t)
- Elsevier BV, 2021
- 2021
- English.
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In: NeuroImage. - : Elsevier BV. - 1053-8119 .- 1095-9572. ; 245
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Abstract
Subject headings
Close
- Dopamine (DA) integrity is suggested as a potential cause of individual differences in working memory (WM) performance among older adults. Still, the principal dopaminergic mechanisms giving rise to WM differences remain unspecified. Here, 61 single-nucleotide polymorphisms, located in or adjacent to various dopamine-related genes, were assessed for their links to WM performance in a sample of 1313 adults aged 61–80 years from the Berlin Aging Study II. Least Absolute Shrinkage and Selection Operator (LASSO) regression was conducted to estimate associations between polymorphisms and WM. Rs40184 in the DA transporter gene, SLC6A3, showed allelic group differences in WM, with T-carriers performing better than C homozygotes (p<0.01). This finding was replicated in an independent sample from the Cognition, Brain, and Aging study (COBRA; baseline: n = 181, ages: 64–68 years; 5-year follow up: n = 129). In COBRA, in vivo DA integrity was measured with 11C-raclopride and positron emission tomography. Notably, WM as well as in vivo DA integrity was higher for rs40184 T-carriers at baseline (p<0.05 for WM and caudate and hippocampal D2-receptor availability) and at the 5-year follow-up (p<0.05 for WM and hippocampal D2 availability). Our findings indicate that individual differences in DA transporter function contribute to differences in WM performance in old age, presumably by regulating DA availability.
Subject headings
- SAMHÄLLSVETENSKAP -- Psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- 11 C-raclopride
- Dopamine D2 receptor
- Dopamine transporter
- Single-nucleotide polymorphisms
- Working memory
- 11C-raclopride
Publication and Content Type
- ref (subject category)
- art (subject category)
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NeuroImage
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- By the author/editor
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Karalija, Nina, ...
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Köhncke, Ylva
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Düzel, Sandra
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Bertram, Lars
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Papenberg, Goran
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Demuth, Ilja
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Lill, Christina ...
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Johansson, Jarkk ...
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Riklund, Katrine ...
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Lövdén, Martin, ...
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Bäckman, Lars
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Nyberg, Lars, 19 ...
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Lindenberger, Ul ...
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Brandmaier, Andr ...
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- About the subject
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- SOCIAL SCIENCES
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SOCIAL SCIENCES
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and Psychology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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NeuroImage
- By the university
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University of Gothenburg
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Umeå University
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Karolinska Institutet