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Natural history and...
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Petersson, M.Karolinska Institutet,Karolinska Univ Hosp, Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Endocrinol, SE-17176 Stockholm, Sweden.,Karolinska University Hospital
(författare)
Natural history and surgical outcome of Rathke's cleft cysts-A study from the Swedish Pituitary Registry
- Artikel/kapitelEngelska2022
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Nummerbeteckningar
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LIBRIS-ID:oai:gup.ub.gu.se/309865
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https://gup.ub.gu.se/publication/309865URI
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https://doi.org/10.1111/cen.14622DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-95304URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-189568URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-181197URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:148071507URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-468881URI
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https://lup.lub.lu.se/record/6ecdaf06-024a-4876-8d63-d08a1262029eURI
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Ämneskategori:art swepub-publicationtype
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Objective Rathke's cleft cysts are benign, embryological remnants in the pituitary gland. The majority of them are small and asymptomatic but a few may become large, and cause mass effects, pituitary hormone deficiencies and visual impairment. Recommendations for the follow-up of Rathke's cleft cysts vary since data on the natural history are sparse. Patients and Design Data at diagnosis and at 1, 5 and 10 years for patients with a Rathke's cleft cyst (434 at diagnosis, 317 females) were retrieved from the Swedish Pituitary Registry. Cysts <= 3 mm in diameter were excluded from the study. Measurements Data included demographics, cyst size, pituitary function, visual defects and surgery. Results The mean age at diagnosis was 45 years. In patients with cysts <10 mm in diameter (n = 204) 2.9% had pituitary hormone deficiencies and 2% had visual field impairments. Cyst size did not progress during the 5 years. Cysts with a diameter of >= 10 mm that were not operated (n = 174) decreased in size over the years (p < .01). Pituitary hormone deficiencies and visual impairments were more frequent (18% and 5.7%, respectively) but were stable over time. Transphenoidal surgery was performed in 56 patients of whom 51 underwent surgery before the 1-year follow-up. The mean cyst diameter at diagnosis was 18 mm (range: 930 mm), 36% had pituitary hormone deficiency, 45% had visual field defects and 20% had impaired visual acuity. One year after surgery 60% had no cyst remnants, 50% had a pituitary deficiency, 26% had visual field defects and 12% had impaired visual acuity. No major changes were observed after 5 years. Twelve of the operated patients had a follow-up at 10 years, in eight the cyst remnants or recurrences increased in size over time (p < .05). Conclusions Rathke's cleft cysts with a size less than 10 mm rarely grow and our results indicate that radiological follow-up can be restricted to 5 years. In contrast, progression of postoperative remnants or recurrent cysts is more likely and require long-term follow-up.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Berinder, K.Karolinska Institutet,Karolinska Univ Hosp, Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Endocrinol, SE-17176 Stockholm, Sweden.,Karolinska University Hospital
(författare)
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Ekman, Bertil,1958-Linköping University,Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Endokrinmedicinska kliniken,Linköping Univ, Dept Endocrinol Linköping, Linköping, Sweden.;Linköping Univ, Dept Hlth Med & Caring Sci, Linköping, Sweden.(Swepub:liu)berek83
(författare)
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Tsatsaris, ErikaUppsala universitet,Endokrinologi och mineralmetabolism,Uppsala University Hospital(Swepub:uu)erits420
(författare)
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Ekman, B.
(författare)
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Wahlberg, Jeanette,1969-Örebro University,Linköping University,Linköpings universitet,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Endocrinology in Linköping and Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden; Department of Internal Medicine, School of Health and Medical Sciences, Örebro University, Örebro, Sweden,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Endokrinmedicinska kliniken,Linköping Univ, Dept Endocrinol Linköping, Linköping, Sweden.;Linköping Univ, Dept Hlth Med & Caring Sci, Linköping, Sweden.;Örebro Univ, Sch Hlth & Med Sci, Dept Internal Med, Örebro, Sweden.(Swepub:liu)jeawa98
(författare)
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Burman, PiaLund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-bap
(författare)
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Borg, HenrikLund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,Skåne University Hospital(Swepub:lu)he1116bo
(författare)
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Siesjö, PeterLund University,Lunds universitet,Neurokirurgi,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Neurosurgery,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital(Swepub:lu)nkir-psi
(författare)
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Dahlqvist, PerUmeå University,Umeå universitet,Avdelningen för medicin,Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden,Umeå Univ, Dept Publ Hlth & Clin Med, Umeå, Sweden.(Swepub:umu)perdat96
(författare)
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Akerman, A. K.Örebro University,Karolinska Institutet,Örebro Univ, Sch Hlth & Med Sci, Dept Internal Med, Örebro, Sweden.
(författare)
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Ragnarsson, Oskar,1971Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Department of Internal Medicine and Clinical Nutrition, Institute of Medicine at Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden,Univ Gothenburg, Inst Med Sahlgrenska Acad, Dept Internal Med & Clin Nutr, Gothenburg, Sweden.(Swepub:gu)xragos
(författare)
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Olsson, M.Department of Neurosurgery, Karolinska University Hospital, Stockholm, Sweden,Karolinska Univ Hosp, Dept Neurosurg, Stockholm, Sweden.
(författare)
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Forander, P.Karolinska Institutet,Karolinska Univ Hosp, Dept Neurosurg, Stockholm, Sweden.,Karolinska University Hospital
(författare)
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Bensing, S.Karolinska Institutet,Karolinska Univ Hosp, Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Endocrinol, SE-17176 Stockholm, Sweden.,Karolinska University Hospital
(författare)
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Hoybye, C.Karolinska Institutet,Karolinska Univ Hosp, Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Endocrinol, SE-17176 Stockholm, Sweden.,Karolinska University Hospital
(författare)
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Edén Engström, BrittUppsala universitet,Endokrinologi och mineralmetabolism,Uppsala University Hospital(Swepub:uu)brittee
(författare)
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Karolinska InstitutetKarolinska Univ Hosp, Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Endocrinol, SE-17176 Stockholm, Sweden.
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Clinical Endocrinology: Wiley96:1, s. 54-610300-06641365-2265
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Petersson, M.
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Berinder, K.
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Ekman, Bertil, 1 ...
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Tsatsaris, Erika
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Ekman, B.
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Wahlberg, Jeanet ...
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Burman, Pia
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Borg, Henrik
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Siesjö, Peter
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Dahlqvist, Per
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Akerman, A. K.
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Ragnarsson, Oska ...
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Olsson, M.
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Forander, P.
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Bensing, S.
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Hoybye, C.
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Edén Engström, B ...
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