Search: WFRF:(Light D) >
Tripartite Relation...
Tripartite Relationship Among Synaptic, Amyloid, and Tau Proteins An In Vivo and Postmortem Study
-
Casaletto, K. B. (author)
-
- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
-
- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
-
show more...
-
- Brinkmalm, Ann (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
-
Honer, W. (author)
-
Schneider, J. A. (author)
-
Bennett, D. A. (author)
-
Djukic, N. (author)
-
You, M. (author)
-
Weiner-Light, S. (author)
-
Fonseca, C. (author)
-
Miller, B. L. (author)
-
Kramer, J. (author)
-
show less...
-
(creator_code:org_t)
- 2021-05-04
- 2021
- English.
-
In: Neurology. - : Ovid Technologies (Wolters Kluwer Health). - 0028-3878 .- 1526-632X. ; 97:3
- Related links:
-
https://gup.ub.gu.se...
-
show more...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Objective To test the hypothesis that fundamental relationships along the amyloid, tau, and neurodegeneration (A/T/N) cascade depend on synaptic integrity in older adults in vivo and postmortem. Methods The 2 independent observational, cross-sectional cohorts included (1) in vivo community-dwelling, clinically normal adults from the University of California, San Francisco Memory and Aging Center who completed lumbar puncture and MRI (exclusion criteria, Clinical Dementia Rating score >0) and (2) postmortem decedents from the Rush Memory and Aging Project (exclusion criteria, inability to sign informed consent). In vivo measures included CSF synaptic proteins (synaptotagmin-1, synaptosome associated protein-25, neurogranin, and growth associated protein-43), beta-amyloid (A beta(42/40)), tau phosphorylated at amino acid 181 (ptau(181)), and MRI gray matter volume (GMV). Postmortem measures captured brain tissue levels of presynaptic proteins (complexin-I, complexin-II, vesicle associated membrane protein (VAMP), and SNARE complex) and neuritic plaque and neurofibrillary tangle (NFT) counts. Regression models tested statistical moderation of synaptic protein levels along the A/T/N cascade (synaptic proteins x amyloid on tau, and synaptic proteins x tau on GMV). Results Sixty-eight in vivo older adults (age 71 years, 43% female) and 633 decedents (age 90 years, 68% female, 34% clinically normal) were included. Each in vivo CSF synaptic protein moderated the relationship between A beta(42/40) and ptau(181) (-0.23 < beta < -0.12, p < 0.05) and the relationship between ptau(181) and GMV (-0.49
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- alzheimers-disease
- memory
- beta
- decline
- neurogranin
- resilience
- Neurosciences & Neurology
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
-
Neurology
(Search for host publication in LIBRIS)
To the university's database
- By the author/editor
-
Casaletto, K. B.
-
Zetterberg, Henr ...
-
Blennow, Kaj, 19 ...
-
Brinkmalm, Ann
-
Honer, W.
-
Schneider, J. A.
-
show more...
-
Bennett, D. A.
-
Djukic, N.
-
You, M.
-
Weiner-Light, S.
-
Fonseca, C.
-
Miller, B. L.
-
Kramer, J.
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Neurology
- Articles in the publication
-
Neurology
- By the university
-
University of Gothenburg