Search: WFRF:(Grundler D.) >
First-in-Humans App...
First-in-Humans Application of Tb-161: A Feasibility Study Using Tb-161-DOTATOC
-
Baum, R. P. (author)
-
Singh, A. (author)
-
Kulkarni, H. R. (author)
-
show more...
-
- Bernhardt, Peter, 1966 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för medicinsk strålningsvetenskap,Institute of Clinical Sciences, Department of Medical Radiation Sciences
-
- Rydén, Tobias (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för medicinsk strålningsvetenskap,Institute of Clinical Sciences, Department of Medical Radiation Sciences
-
Schuchardt, C. (author)
-
Gracheva, N. (author)
-
Grundler, P. V. (author)
-
Koster, U. (author)
-
Muller, D. (author)
-
Prohl, M. (author)
-
Zeevaart, J. R. (author)
-
Schibli, R. (author)
-
van der Meulen, N. P. (author)
-
Muller, C. (author)
-
show less...
-
(creator_code:org_t)
- 2021-02-05
- 2021
- English.
-
In: Journal of Nuclear Medicine. - : Society of Nuclear Medicine. - 0161-5505 .- 2159-662X. ; 62:10, s. 1391-1397
- Related links:
-
https://jnm.snmjourn...
-
show more...
-
https://gup.ub.gu.se...
-
https://doi.org/10.2...
-
show less...
Abstract
Subject headings
Close
- Tb-161 has decay properties similar to those of Lu-177 but, additionally, emits a substantial number of conversion and Auger electrons. The aim of this study was to apply Tb-161 in a clinical setting and to investigate the feasibility of visualizing the physiologic and tumor biodistributions of Tb-161-DOTATOC. Methods: Tb-161 was shipped from Paul Scherrer Institute, Villigen-PSI, Switzerland, to Zentralklinik Bad Berka, Bad Berka, Germany, where it was used for the radiolabeling of DOTATOC. In 2 separate studies, 596 and 1,300 MBq of Tb-161-DOTATOC were administered to a 35-y-old male patient with a metastatic, well-differentiated, nonfunctional malignant paraganglioma and a 70-y-old male patient with a metastatic, functional neuroendocrine neoplasm of the pancreatic tail, respectively. Whole-body planar g-scintigraphy images were acquired over a period of several days for dosimetry calculations. SPECT/CT images were reconstructed using a recently established protocol and visually analyzed. Patients were observed for adverse events after the application of Tb-161-DOTATOC. Results: The radiolabeling of DOTATOC with Tb-161 was readily achieved with a high radiochemical purity suitable for patient application. Planar images and dosimetry provided the expected time-dependent biodistribution of Tb-161-DOTATOC in the liver, kidneys, spleen, and urinary bladder. SPECT/CT images were of high quality and visualized even small metastases in bones and liver. The application of Tb-161-DOTATOC was well tolerated, and no related adverse events were reported. Conclusion: This study demonstrated the feasibility of imaging even small metastases after the injection of relatively low activities of Tb-161-DOTATOC using g-scintigraphy and SPECT/CT. On the basis of this essential first step in translating Tb-161 to clinics, further efforts will be directed toward the application of Tb-161 for therapeutic purposes.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Keyword
- Tb-161
- SPECT/CT imaging
- DOTATOC
- Auger electrons
- first-in-humans
- therapy
- lu-177
- radionuclides
- spect
- Radiology
- Nuclear Medicine & Medical Imaging
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Baum, R. P.
-
Singh, A.
-
Kulkarni, H. R.
-
Bernhardt, Peter ...
-
Rydén, Tobias
-
Schuchardt, C.
-
show more...
-
Gracheva, N.
-
Grundler, P. V.
-
Koster, U.
-
Muller, D.
-
Prohl, M.
-
Zeevaart, J. R.
-
Schibli, R.
-
van der Meulen, ...
-
Muller, C.
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Radiology Nuclea ...
- Articles in the publication
-
Journal of Nucle ...
- By the university
-
University of Gothenburg