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Antiphospholipid an...
Antiphospholipid antibodies and neurological manifestations in acute COVID-19: A single-centre cross-sectional study
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Benjamin, L. A. (author)
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Paterson, R. W. (author)
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Moll, R. (author)
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Pericleous, C. (author)
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Brown, R. (author)
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Mehta, P. R. (author)
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Athauda, D. (author)
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Ziff, O. J. (author)
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Heaney, J. (author)
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Checkley, A. M. (author)
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Houlihan, C. F. (author)
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Chou, M. (author)
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Heslegrave, A. J. (author)
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Chandratheva, A. (author)
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Michael, B. D. (author)
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Vivekanandam, V. (author)
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Foulkes, A. (author)
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Mummerya, C. J. (author)
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Lunn, M. P. (author)
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Keddie, S. (author)
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Spyer, M. J. (author)
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McKinnon, T. (author)
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Hart, M. (author)
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Carletti, F. (author)
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Jager, H. R. (author)
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Manji, H. (author)
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Zandi, M. S. (author)
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Werring, D. J. (author)
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Nastoulik, E. (author)
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Simister, R. (author)
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Solomon, T. (author)
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Schott, J. M. (author)
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Cohen, H. (author)
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Efthymiou, M. (author)
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(creator_code:org_t)
- Elsevier BV, 2021
- 2021
- English.
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In: Eclinicalmedicine. - : Elsevier BV. - 2589-5370. ; 39
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http://www.thelancet...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
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- Background: A high prevalence of antiphospholipid antibodies has been reported in case series of patients with neurological manifestations and COVID-19; however, the pathogenicity of antiphospholipid antibodies in COVID-19 neurology remains unclear. Methods: This single-centre cross-sectional study included 106 adult patients: 30 hospitalised COVID-neurological cases, 47 non-neurological COVID-hospitalised controls, and 29 COVID-non-hospitalised controls, recruited between March and July 2020. We evaluated nine antiphospholipid antibodies: anticardiolipin antibodies [aCL] IgA, IgM, IgG; anti-beta-2 glycoprotein-1 [a beta(2)GPI] IgA, IgM, IgG; anti-phosphatidylserine/prothrombin [aPS/PT] IgM, IgG; and anti-domain I b2GPI (aD1 beta 2GPI) IgG. Findings: There was a high prevalence of antiphospholipid antibodies in the COVID-neurological (73.3%) and non-neurological COVID-hospitalised controls (76.6%) in contrast to the COVID-non-hospitalised controls (48.2%). aPS/PT IgG titres were significantly higher in the COVID-neurological group compared to both control groups (p < 0.001). Moderate-high titre of aPS/PT IgG was found in 2 out of 3 (67%) patients with acute disseminated encephalomyelitis [ADEM]. aPS/PT IgG titres negatively correlated with oxygen requirement (FiO(2) R=-0.15 p = 0.040) and was associated with venous thromboembolism (p = 0.043). In contrast, aCL IgA (p < 0.001) and IgG (p < 0.001) was associated with non-neurological COVID-hospitalised controls compared to the other groups and correlated positively with D-dimer and creatinine but negatively with FiO(2). Interpretation: Our findings show that aPS/PT IgG is associated with COVID-19-associated ADEM. In contrast, aCL IgA and IgG are seen much more frequently in non-neurological hospitalised patients with COVID-19. Characterisation of antiphospholipid antibody persistence and potential longitudinal clinical impact are required to guide appropriate management. (C) 2021 The Author(s). Published by Elsevier Ltd.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences (hsv//eng)
Keyword
- guidelines
- thrombosis
- infection
- update
- risk
- General & Internal Medicine
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Benjamin, L. A.
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Paterson, R. W.
-
Moll, R.
-
Pericleous, C.
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Brown, R.
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Mehta, P. R.
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show more...
-
Athauda, D.
-
Ziff, O. J.
-
Heaney, J.
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Checkley, A. M.
-
Houlihan, C. F.
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Chou, M.
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Heslegrave, A. J ...
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Chandratheva, A.
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Michael, B. D.
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Blennow, Kaj, 19 ...
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Vivekanandam, V.
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Foulkes, A.
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Mummerya, C. J.
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Lunn, M. P.
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Keddie, S.
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Spyer, M. J.
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McKinnon, T.
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Hart, M.
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Carletti, F.
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Jager, H. R.
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Manji, H.
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Zandi, M. S.
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Werring, D. J.
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Nastoulik, E.
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Simister, R.
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Solomon, T.
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Zetterberg, Henr ...
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Schott, J. M.
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Cohen, H.
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Efthymiou, M.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
- Articles in the publication
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Eclinicalmedicin ...
- By the university
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University of Gothenburg