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Circulating growth ...
Circulating growth differentiation factor 15 is increased preceding preeclampsia diagnosis: Implications as a disease biomarker
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- Cruickshank, Tess (author)
- Mercy Hosp Women, Translat Obstet Grp, Heidelberg, Vic, Australia.;Mercy Hosp Women, Dept Obstet & Gynaecol, Heidelberg, Vic, Australia.
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- Macdonald, Teresa M. (author)
- Mercy Hosp Women, Dept Obstet & Gynaecol, Heidelberg, Vic, Australia.;Mercy Hosp Women, Mercy Perinatal, Heidelberg, Vic, Australia.
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- Walker, Susan P. (author)
- Mercy Hosp Women, Dept Obstet & Gynaecol, Heidelberg, Vic, Australia.;Mercy Hosp Women, Mercy Perinatal, Heidelberg, Vic, Australia.
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- Keenan, Emerson (author)
- Mercy Hosp Women, Dept Obstet & Gynaecol, Heidelberg, Vic, Australia.
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- Dane, Kirsten (author)
- Mercy Hosp Women, Mercy Perinatal, Heidelberg, Vic, Australia.
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- Middleton, Anna (author)
- Mercy Hosp Women, Dept Obstet & Gynaecol, Heidelberg, Vic, Australia.;Mercy Hosp Women, Mercy Perinatal, Heidelberg, Vic, Australia.
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- Kyritsis, Valerie (author)
- Mercy Hosp Women, Mercy Perinatal, Heidelberg, Vic, Australia.
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- Myers, Jenny (author)
- Univ Manchester, St Marys Hosp, Manchester Acad Hlth Sci Ctr, Manchester, Lancs, England.
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- Cluver, Catherine (author)
- Mercy Hosp Women, Translat Obstet Grp, Heidelberg, Vic, Australia.;Mercy Hosp Women, Mercy Perinatal, Heidelberg, Vic, Australia.;Univ Stellenbosch, Tygerberg Hosp, Dept Obstet & Gynecol, Cape Town, South Africa.
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- Hastie, Roxanne (author)
- Mercy Hosp Women, Translat Obstet Grp, Heidelberg, Vic, Australia.;Mercy Hosp Women, Dept Obstet & Gynaecol, Heidelberg, Vic, Australia.;Mercy Hosp Women, Mercy Perinatal, Heidelberg, Vic, Australia.
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- Bergman, Lina, 1982 (author)
- Uppsala universitet,Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology,Klinisk obstetrik,Univ Stellenbosch, Tygerberg Hosp, Dept Obstet & Gynecol, Cape Town, South Africa.;Sahlgrenska Acad Univ Gothenburg, Dept Obstet, Gothenburg, Sweden.;Sahlgrenska Acad Univ Gothenburg, Inst Clin Sci, Gothenburg, Sweden.
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- Garcha, Damanpreet (author)
- Mercy Hosp Women, Translat Obstet Grp, Heidelberg, Vic, Australia.;Mercy Hosp Women, Dept Obstet & Gynaecol, Heidelberg, Vic, Australia.
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- Cannon, Ping (author)
- Mercy Hosp Women, Translat Obstet Grp, Heidelberg, Vic, Australia.;Mercy Hosp Women, Dept Obstet & Gynaecol, Heidelberg, Vic, Australia.
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- Murray, Elizabeth (author)
- Mercy Hosp Women, Translat Obstet Grp, Heidelberg, Vic, Australia.;Mercy Hosp Women, Dept Obstet & Gynaecol, Heidelberg, Vic, Australia.
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- Nguyen, Tuong Vi (author)
- Mercy Hosp Women, Translat Obstet Grp, Heidelberg, Vic, Australia.;Mercy Hosp Women, Dept Obstet & Gynaecol, Heidelberg, Vic, Australia.
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- Hiscock, Richard (author)
- Mercy Hosp Women, Dept Obstet & Gynaecol, Heidelberg, Vic, Australia.
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- Pritchard, Natasha (author)
- Mercy Hosp Women, Translat Obstet Grp, Heidelberg, Vic, Australia.;Mercy Hosp Women, Dept Obstet & Gynaecol, Heidelberg, Vic, Australia.;Mercy Hosp Women, Mercy Perinatal, Heidelberg, Vic, Australia.
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- Hannan, Natalie J. (author)
- Mercy Hosp Women, Translat Obstet Grp, Heidelberg, Vic, Australia.;Mercy Hosp Women, Dept Obstet & Gynaecol, Heidelberg, Vic, Australia.;Mercy Hosp Women, Mercy Perinatal, Heidelberg, Vic, Australia.
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- Tong, Stephen (author)
- Mercy Hosp Women, Translat Obstet Grp, Heidelberg, Vic, Australia.;Mercy Hosp Women, Dept Obstet & Gynaecol, Heidelberg, Vic, Australia.;Mercy Hosp Women, Mercy Perinatal, Heidelberg, Vic, Australia.
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- Kaitu’u-Lino, Tu’Uhevaha J. (author)
- Mercy Hosp Women, Translat Obstet Grp, Heidelberg, Vic, Australia.;Mercy Hosp Women, Dept Obstet & Gynaecol, Heidelberg, Vic, Australia.;Mercy Hosp Women, Mercy Perinatal, Heidelberg, Vic, Australia.
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Mercy Hosp Women, Translat Obstet Grp, Heidelberg, Vic, Australia;Mercy Hosp Women, Dept Obstet & Gynaecol, Heidelberg, Vic, Australia. Mercy Hosp Women, Dept Obstet & Gynaecol, Heidelberg, Vic, Australia.;Mercy Hosp Women, Mercy Perinatal, Heidelberg, Vic, Australia. (creator_code:org_t)
- John Wiley & Sons, 2021
- 2021
- English.
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In: Journal of the American Heart Association. - : John Wiley & Sons. - 2047-9980. ; 10:16
- Related links:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
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- BACKGROUND: We investigated the biomarker potential of growth differentiation factor 15 (GDF-15), a stress response protein highly expressed in placenta, to predict preeclampsia. METHODS AND RESULTS: In 2 prospective cohorts (cohort 1: 960 controls, 39 women who developed preeclampsia; cohort 2: 950 controls, 41 developed preeclampsia), plasma concentrations of GDF-15 at 36 weeks’ gestation were significantly increased among those who developed preeclampsia (P<0.001), area under the receiver operating characteristic curves (AUC) of 0.66 and 0.71, respectively. In cohort 2 a ratio of sFlt-1/PlGF (a clinical biomarker for preeclampsia) had a sensitivity of 61.0% at 83.2% specificity to predict those who will develop preeclampsia (AUC of 0.79). A ratio of GDF-15×sFlt-1/PlGF yielded a sensitivity of 68.3% at 83.2% specificity (AUC of 0.82). GDF-15 was consistently elevated across a number of international cohorts: levels were higher in placenta and blood from women delivering <34 weeks’ gestation due to preterm preeclampsia in Melbourne, Australia; and in the blood at 26 to 32 weeks’ gestation among 57 women attending the Manchester Antenatal Vascular Service (MAViS, UK) who developed preeclampsia (P=0.0002), compared with 176 controls. In the Preeclampsia Obstetric adVerse Events biobank (PROVE, South Africa), plasma GDF-15 was significantly increased in women with preec-lampsia with severe features (P=0.02; n=14) compared to controls (n=14). CONCLUSIONS: We conclude circulating GDF-15 is elevated among women more likely to develop preeclampsia or diagnosed with the condition. It may have value as a clinical biomarker, including the potential to improve the sensitivity of sFlt-1/PlGF ratio.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Keyword
- Biomarker
- Placental growth factor
- Preeclampsia
- Pregnancy
- biomarker
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Cruickshank, Tes ...
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Macdonald, Teres ...
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Walker, Susan P.
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Keenan, Emerson
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Dane, Kirsten
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Middleton, Anna
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show more...
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Kyritsis, Valeri ...
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Myers, Jenny
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Cluver, Catherin ...
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Hastie, Roxanne
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Bergman, Lina, 1 ...
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Garcha, Damanpre ...
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Cannon, Ping
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Murray, Elizabet ...
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Nguyen, Tuong Vi
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Hiscock, Richard
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Pritchard, Natas ...
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Hannan, Natalie ...
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Tong, Stephen
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Kaitu’u-Lino, Tu ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Obstetrics Gynae ...
- Articles in the publication
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Journal of the A ...
- By the university
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University of Gothenburg
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Uppsala University