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  • Cruickshank, TessMercy Hosp Women, Translat Obstet Grp, Heidelberg, Vic, Australia.;Mercy Hosp Women, Dept Obstet & Gynaecol, Heidelberg, Vic, Australia. (författare)

Circulating growth differentiation factor 15 is increased preceding preeclampsia diagnosis: Implications as a disease biomarker

  • Artikel/kapitelEngelska2021

Förlag, utgivningsår, omfång ...

  • John Wiley & Sons,2021

Nummerbeteckningar

  • LIBRIS-ID:oai:gup.ub.gu.se/310792
  • https://gup.ub.gu.se/publication/310792URI
  • https://doi.org/10.1161/JAHA.120.020302DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-452717URI

Kompletterande språkuppgifter

  • Språk:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • BACKGROUND: We investigated the biomarker potential of growth differentiation factor 15 (GDF-15), a stress response protein highly expressed in placenta, to predict preeclampsia. METHODS AND RESULTS: In 2 prospective cohorts (cohort 1: 960 controls, 39 women who developed preeclampsia; cohort 2: 950 controls, 41 developed preeclampsia), plasma concentrations of GDF-15 at 36 weeks’ gestation were significantly increased among those who developed preeclampsia (P<0.001), area under the receiver operating characteristic curves (AUC) of 0.66 and 0.71, respectively. In cohort 2 a ratio of sFlt-1/PlGF (a clinical biomarker for preeclampsia) had a sensitivity of 61.0% at 83.2% specificity to predict those who will develop preeclampsia (AUC of 0.79). A ratio of GDF-15×sFlt-1/PlGF yielded a sensitivity of 68.3% at 83.2% specificity (AUC of 0.82). GDF-15 was consistently elevated across a number of international cohorts: levels were higher in placenta and blood from women delivering <34 weeks’ gestation due to preterm preeclampsia in Melbourne, Australia; and in the blood at 26 to 32 weeks’ gestation among 57 women attending the Manchester Antenatal Vascular Service (MAViS, UK) who developed preeclampsia (P=0.0002), compared with 176 controls. In the Preeclampsia Obstetric adVerse Events biobank (PROVE, South Africa), plasma GDF-15 was significantly increased in women with preec-lampsia with severe features (P=0.02; n=14) compared to controls (n=14). CONCLUSIONS: We conclude circulating GDF-15 is elevated among women more likely to develop preeclampsia or diagnosed with the condition. It may have value as a clinical biomarker, including the potential to improve the sensitivity of sFlt-1/PlGF ratio.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Macdonald, Teresa M.Mercy Hosp Women, Dept Obstet & Gynaecol, Heidelberg, Vic, Australia.;Mercy Hosp Women, Mercy Perinatal, Heidelberg, Vic, Australia. (författare)
  • Walker, Susan P.Mercy Hosp Women, Dept Obstet & Gynaecol, Heidelberg, Vic, Australia.;Mercy Hosp Women, Mercy Perinatal, Heidelberg, Vic, Australia. (författare)
  • Keenan, EmersonMercy Hosp Women, Dept Obstet & Gynaecol, Heidelberg, Vic, Australia. (författare)
  • Dane, KirstenMercy Hosp Women, Mercy Perinatal, Heidelberg, Vic, Australia. (författare)
  • Middleton, AnnaMercy Hosp Women, Dept Obstet & Gynaecol, Heidelberg, Vic, Australia.;Mercy Hosp Women, Mercy Perinatal, Heidelberg, Vic, Australia. (författare)
  • Kyritsis, ValerieMercy Hosp Women, Mercy Perinatal, Heidelberg, Vic, Australia. (författare)
  • Myers, JennyUniv Manchester, St Marys Hosp, Manchester Acad Hlth Sci Ctr, Manchester, Lancs, England. (författare)
  • Cluver, CatherineMercy Hosp Women, Translat Obstet Grp, Heidelberg, Vic, Australia.;Mercy Hosp Women, Mercy Perinatal, Heidelberg, Vic, Australia.;Univ Stellenbosch, Tygerberg Hosp, Dept Obstet & Gynecol, Cape Town, South Africa. (författare)
  • Hastie, RoxanneMercy Hosp Women, Translat Obstet Grp, Heidelberg, Vic, Australia.;Mercy Hosp Women, Dept Obstet & Gynaecol, Heidelberg, Vic, Australia.;Mercy Hosp Women, Mercy Perinatal, Heidelberg, Vic, Australia. (författare)
  • Bergman, Lina,1982Uppsala universitet,Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology,Klinisk obstetrik,Univ Stellenbosch, Tygerberg Hosp, Dept Obstet & Gynecol, Cape Town, South Africa.;Sahlgrenska Acad Univ Gothenburg, Dept Obstet, Gothenburg, Sweden.;Sahlgrenska Acad Univ Gothenburg, Inst Clin Sci, Gothenburg, Sweden.(Swepub:uu)linbe681 (författare)
  • Garcha, DamanpreetMercy Hosp Women, Translat Obstet Grp, Heidelberg, Vic, Australia.;Mercy Hosp Women, Dept Obstet & Gynaecol, Heidelberg, Vic, Australia. (författare)
  • Cannon, PingMercy Hosp Women, Translat Obstet Grp, Heidelberg, Vic, Australia.;Mercy Hosp Women, Dept Obstet & Gynaecol, Heidelberg, Vic, Australia. (författare)
  • Murray, ElizabethMercy Hosp Women, Translat Obstet Grp, Heidelberg, Vic, Australia.;Mercy Hosp Women, Dept Obstet & Gynaecol, Heidelberg, Vic, Australia. (författare)
  • Nguyen, Tuong ViMercy Hosp Women, Translat Obstet Grp, Heidelberg, Vic, Australia.;Mercy Hosp Women, Dept Obstet & Gynaecol, Heidelberg, Vic, Australia. (författare)
  • Hiscock, RichardMercy Hosp Women, Dept Obstet & Gynaecol, Heidelberg, Vic, Australia. (författare)
  • Pritchard, NatashaMercy Hosp Women, Translat Obstet Grp, Heidelberg, Vic, Australia.;Mercy Hosp Women, Dept Obstet & Gynaecol, Heidelberg, Vic, Australia.;Mercy Hosp Women, Mercy Perinatal, Heidelberg, Vic, Australia. (författare)
  • Hannan, Natalie J.Mercy Hosp Women, Translat Obstet Grp, Heidelberg, Vic, Australia.;Mercy Hosp Women, Dept Obstet & Gynaecol, Heidelberg, Vic, Australia.;Mercy Hosp Women, Mercy Perinatal, Heidelberg, Vic, Australia. (författare)
  • Tong, StephenMercy Hosp Women, Translat Obstet Grp, Heidelberg, Vic, Australia.;Mercy Hosp Women, Dept Obstet & Gynaecol, Heidelberg, Vic, Australia.;Mercy Hosp Women, Mercy Perinatal, Heidelberg, Vic, Australia. (författare)
  • Kaitu’u-Lino, Tu’Uhevaha J.Mercy Hosp Women, Translat Obstet Grp, Heidelberg, Vic, Australia.;Mercy Hosp Women, Dept Obstet & Gynaecol, Heidelberg, Vic, Australia.;Mercy Hosp Women, Mercy Perinatal, Heidelberg, Vic, Australia. (författare)
  • Mercy Hosp Women, Translat Obstet Grp, Heidelberg, Vic, Australia.;Mercy Hosp Women, Dept Obstet & Gynaecol, Heidelberg, Vic, Australia.Mercy Hosp Women, Dept Obstet & Gynaecol, Heidelberg, Vic, Australia.;Mercy Hosp Women, Mercy Perinatal, Heidelberg, Vic, Australia. (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Journal of the American Heart Association: John Wiley & Sons10:162047-9980

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