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  • Paterson, Ross W (author)

Serum and cerebrospinal fluid biomarker profiles in acute SARS-CoV-2-associated neurological syndromes.

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • 2021-05-12
  • Oxford University Press (OUP),2021

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/310869
  • https://gup.ub.gu.se/publication/310869URI
  • https://doi.org/10.1093/braincomms/fcab099DOI

Supplementary language notes

  • Language:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Preliminary pathological and biomarker data suggest that SARS-CoV-2 infection can damage the nervous system. To understand what, where and how damage occurs, we collected serum and CSF from patients with COVID-19 and characterized neurological syndromes involving the PNS and CNS (n=34). We measured biomarkers of neuronal damage and neuroinflammation, and compared these with non-neurological control groups, which included patients with (n=94) and without (n=24) COVID-19. We detected increased concentrations of neurofilament light, a dynamic biomarker of neuronal damage, in the CSF of those with CNS inflammation (encephalitis and acute disseminated encephalomyelitis) [14800pg/ml (400, 32400)], compared to those with encephalopathy [1410pg/ml (756, 1446)], peripheral syndromes (Guillain-Barré syndrome) [740pg/ml (507, 881)] and controls [872pg/ml (654, 1200)]. Serum neurofilament light levels were elevated across patients hospitalized with COVID-19, irrespective of neurological manifestations. There was not the usual close correlation between CSF and serum neurofilament light, suggesting serum neurofilament light elevation in the non-neurological patients may reflect peripheral nerve damage in response to severe illness. We did not find significantly elevated levels of serum neurofilament light in community cases of COVID-19 arguing against significant neurological damage. Glial fibrillary acidic protein, a marker of astrocytic activation, was not elevated in the CSF or serum of any group, suggesting astrocytic activation is not a major mediator of neuronal damage in COVID-19.

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  • Benjamin, Laura A (author)
  • Mehta, Puja R (author)
  • Brown, Rachel L (author)
  • Athauda, Dilan (author)
  • Ashton, Nicholas J.Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xashtn (author)
  • Leckey, Claire A (author)
  • Ziff, Oliver J (author)
  • Heaney, Judith (author)
  • Heslegrave, Amanda J (author)
  • Lessa Benedet, AndréaGothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xlesan (author)
  • Blennow, Kaj,1958Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xbleka (author)
  • Checkley, Anna M (author)
  • Houlihan, Catherine F (author)
  • Mummery, Catherine J (author)
  • Lunn, Michael P (author)
  • Manji, Hadi (author)
  • Zandi, Michael S (author)
  • Keddie, Stephen (author)
  • Chou, Michael (author)
  • Vinayan Changaradil, Deepthi (author)
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  • Keshavan, Ashvini (author)
  • Barker, Suzanne (author)
  • Jäger, Hans Rolf (author)
  • Carletti, Francesco (author)
  • Simister, Robert (author)
  • Werring, David J (author)
  • Spyer, Moira J (author)
  • Nastouli, Eleni (author)
  • Gauthier, Serge (author)
  • Rosa-Neto, Pedro (author)
  • Zetterberg, Henrik,1973Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xzethe (author)
  • Schott, Jonathan M (author)
  • Göteborgs universitetInstitutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi (creator_code:org_t)

Related titles

  • In:Brain communications: Oxford University Press (OUP)3:32632-1297

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