Search: WFRF:(Tahzeeb Fatima) >
N-acetyl cysteine, ...
N-acetyl cysteine, selenium, and ascorbic acid rescue diabetic cardiac hypertrophy via mitochondrial-associated redox regulators
-
Mushtaq, Iram (author)
-
Bashir, Zainab (author)
-
Sarwar, Mehvish (author)
-
show more...
-
Arshad, Maria (author)
-
Ishtiaq, Ayesha (author)
-
Khan, Wajiha (author)
-
Khan, Uzma (author)
-
Tabassum, Sobia (author)
-
Ali, Tahir (author)
-
- Tahzeeb, Fatima (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research
-
- Valadi, Hadi, 1963 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research
-
- Nawaz, Muhammad (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research
-
Murtaza, Iram (author)
-
show less...
-
(creator_code:org_t)
- 2021-11-30
- 2021
- English.
-
In: Molecules. - : MDPI AG. - 1420-3049. ; 26:23
- Related links:
-
https://www.mdpi.com...
-
show more...
-
https://gup.ub.gu.se...
-
https://doi.org/10.3...
-
show less...
Abstract
Subject headings
Close
- Metabolic disorders often lead to cardiac complications. Metabolic deregulations during diabetic conditions are linked to mitochondrial dysfunctions, which are the key contributing factors in cardiac hypertrophy. However, the underlying mechanisms involved in diabetes-induced cardiac hypertrophy are poorly understood. In the current study, we initially established a diabetic rat model by alloxan-administration, which was validated by peripheral glucose measurement. Diabetic rats displayed myocardial stiffness and fibrosis, changes in heart weight/body weight, heart weight/tibia length ratios, and enhanced size of myocytes, which altogether demonstrated the establishment of diabetic cardiac hypertrophy (DCH). Furthermore, we examined the expression of genes associated with mitochondrial signaling impairment. Our data show that the expression of PGC-1α, cytochrome c, MFN-2, and Drp-1 was deregulated. Mitochondrial-signaling impairment was further validated by redox-system dysregulation, which showed a significant increase in ROS and thiobarbituric acid reactive substances, both in serum and heart tissue, whereas the superoxide dismutase, catalase, and glutathione levels were decreased. Additionally, the expression levels of pro-apoptotic gene PUMA and stress marker GATA-4 genes were elevated, whereas ARC, PPARα, and Bcl-2 expression levels were decreased in the heart tissues of diabetic rats. Importantly, these alloxan-induced impairments were rescued by N-acetyl cysteine, ascorbic acid, and selenium treatment. This was demonstrated by the amelioration of myocardial stiffness, fibrosis, mitochondrial gene expression, lipid profile, restoration of myocyte size, reduced oxidative stress, and the activation of enzymes associated with antioxidant activities. Altogether, these data indicate that the improvement of mitochondrial dysfunction by protective agents such as N-acetyl cysteine, selenium, and ascorbic acid could rescue diabetes-associated cardiac complications, including DCH.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Biomaterialvetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Biomaterials Science (hsv//eng)
Keyword
- Diabetes linked cardiac hypertrophy
- Mitochondrial stress markers
- Reactive oxygen species
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
-
Molecules
(Search for host publication in LIBRIS)
To the university's database
- By the author/editor
-
Mushtaq, Iram
-
Bashir, Zainab
-
Sarwar, Mehvish
-
Arshad, Maria
-
Ishtiaq, Ayesha
-
Khan, Wajiha
-
show more...
-
Khan, Uzma
-
Tabassum, Sobia
-
Ali, Tahir
-
Tahzeeb, Fatima
-
Valadi, Hadi, 19 ...
-
Nawaz, Muhammad
-
Murtaza, Iram
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Medical Biotechn ...
-
and Biomaterials Sci ...
- Articles in the publication
-
Molecules
- By the university
-
University of Gothenburg