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Innate immune respo...
Innate immune response to SARS-CoV-2 infection contributes to neuronal damage in human iPSC-derived peripheral neurons
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- Passos, Vania (författare)
- Hannover Medical School, Institute of Virology, Hannover, Germany
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- Henkel, Lisa M. (författare)
- Department of Neurology, Hannover Medical School, Hannover, Germany
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- Wang, Jiayi (författare)
- Hannover Medical School, Institute of Virology, Hannover, Germany
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- Zapatero-Belinchón, Francisco J. (författare)
- Umeå universitet,Institutionen för klinisk mikrobiologi,University of Veterinary Medicine Hannover, Foundation, Hannover, Germany; Cluster of Excellence-Resolving Infection Susceptibility (RESIST), Hannover Medical School, Hannover, Germany
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- Möller, Rebecca (författare)
- University of Veterinary Medicine Hannover, Foundation, Hannover, Germany
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- Sun, Guorong (författare)
- Hannover Medical School, Institute of Virology, Hannover, Germany
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- Waltl, Inken (författare)
- Institute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, A Joint Venture between the Helmholtz Centre for Infection Research and the Hannover Medical School, Hannover, Germany
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- Schneider, Talia (författare)
- Hannover Medical School, Institute of Virology, Hannover, Germany
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- Wachs, Amelie (författare)
- Hannover Medical School, Institute of Virology, Hannover, Germany
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- Ritter, Birgit (författare)
- Hannover Medical School, Institute of Virology, Hannover, Germany
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- Kropp, Kai A. (författare)
- Hannover Medical School, Institute of Virology, Hannover, Germany
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- Zhu, Shuyong (författare)
- Hannover Medical School, Institute of Virology, Hannover, Germany
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- Deleidi, Michela (författare)
- Center of Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany
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- Kalinke, Ulrich (författare)
- Cluster of Excellence-Resolving Infection Susceptibility (RESIST), Hannover Medical School, Hannover, Germany; Institute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, A Joint Venture between the Helmholtz Centre for Infection Research and the Hannover Medical School, Hannover, Germany
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- Schulz, Thomas F. (författare)
- Hannover Medical School, Institute of Virology, Hannover, Germany; Cluster of Excellence-Resolving Infection Susceptibility (RESIST), Hannover Medical School, Hannover, Germany
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- Höglinger, Günter (författare)
- Department of Neurology, Hannover Medical School, Hannover, Germany; Cluster of Excellence-Resolving Infection Susceptibility (RESIST), Hannover Medical School, Hannover, Germany
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- Gerold, Gisa, 1979- (författare)
- Umeå universitet,Institutionen för klinisk mikrobiologi,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),University of Veterinary Medicine Hannover, Foundation, Hannover, Germany; Cluster of Excellence-Resolving Infection Susceptibility (RESIST), Hannover Medical School, Hannover, Germany
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- Wegner, Florian (författare)
- Department of Neurology, Hannover Medical School, Hannover, Germany
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- Viejo-Borbolla, Abel (författare)
- Hannover Medical School, Institute of Virology, Hannover, Germany; Cluster of Excellence-Resolving Infection Susceptibility (RESIST), Hannover Medical School, Hannover, Germany
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(creator_code:org_t)
- John Wiley & Sons, 2024
- 2024
- Engelska.
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Ingår i: Journal of Medical Virology. - : John Wiley & Sons. - 0146-6615 .- 1096-9071. ; 96:2
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Severe acute respiratory coronavirus 2 (SARS-CoV-2) causes neurological disease in the peripheral and central nervous system (PNS and CNS, respectively) of some patients. It is not clear whether SARS-CoV-2 infection or the subsequent immune response are the key factors that cause neurological disease. Here, we addressed this question by infecting human induced pluripotent stem cell-derived CNS and PNS neurons with SARS-CoV-2. SARS-CoV-2 infected a low number of CNS neurons and did not elicit a robust innate immune response. On the contrary, SARS-CoV-2 infected a higher number of PNS neurons. This resulted in expression of interferon (IFN) λ1, several IFN-stimulated genes and proinflammatory cytokines. The PNS neurons also displayed alterations characteristic of neuronal damage, as increased levels of sterile alpha and Toll/interleukin receptor motif-containing protein 1, amyloid precursor protein and α-synuclein, and lower levels of cytoskeletal proteins. Interestingly, blockade of the Janus kinase and signal transducer and activator of transcription pathway by Ruxolitinib did not increase SARS-CoV-2 infection, but reduced neuronal damage, suggesting that an exacerbated neuronal innate immune response contributes to pathogenesis in the PNS. Our results provide a basis to study coronavirus disease 2019 (COVID-19) related neuronal pathology and to test future preventive or therapeutic strategies.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Nyckelord
- interferon
- iPSC-derived peripheral neurons
- JAK/STAT
- neuronal damage
- SARM1
- SARS-CoV-2
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Passos, Vania
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Henkel, Lisa M.
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Wang, Jiayi
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Zapatero-Belinch ...
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Möller, Rebecca
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Sun, Guorong
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visa fler...
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Waltl, Inken
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Schneider, Talia
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Wachs, Amelie
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Ritter, Birgit
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Kropp, Kai A.
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Zhu, Shuyong
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Deleidi, Michela
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Kalinke, Ulrich
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Schulz, Thomas F ...
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Höglinger, Günte ...
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Gerold, Gisa, 19 ...
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Wegner, Florian
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Viejo-Borbolla, ...
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Neurovetenskaper
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Infektionsmedici ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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