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The impact of Medit...
The impact of Mediterranean diet on coronary plaque vulnerability, microvascular function, inflammation and microbiome after an acute coronary syndrome: study protocol for the MEDIMACS randomized, controlled, mechanistic clinical trial
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Fernandez, A. I. (författare)
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Bermejo, J. (författare)
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Yotti, R. (författare)
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Martinez-Gonzalez, M. A. (författare)
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Mira, A. (författare)
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Gophna, U. (författare)
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- Karlsson, Roger, 1975 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
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Al-Daccak, R. (författare)
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Martin-Demiguel, I. (författare)
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Gutierrez-Ibanes, E. (författare)
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Charron, D. (författare)
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Fernandez-Aviles, F. (författare)
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(creator_code:org_t)
- 2021-11-12
- 2021
- Engelska.
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Ingår i: Trials. - : Springer Science and Business Media LLC. - 1745-6215. ; 22:1
- Relaterad länk:
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https://trialsjourna...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Primary prevention trials have demonstrated that the traditional Mediterranean diet is associated with a reduction in cardiovascular mortality and morbidity. However, this benefit has not been proven for secondary prevention after an acute coronary syndrome (ACS). We hypothesized that a high-intensity Mediterranean diet intervention after an ACS decreases the vulnerability of atherosclerotic plaques by complex interactions between anti-inflammatory effects, microbiota changes and modulation of gene expression. Methods: The MEDIMACS project is an academically funded, prospective, randomized, controlled and mechanistic clinical trial designed to address the effects of an active randomized intervention with the Mediterranean diet on atherosclerotic plaque vulnerability, coronary endothelial dysfunction and other mechanistic endpoints. One hundred patients with ACS are randomized 1:1 to a monitored high-intensity Mediterranean diet intervention or to a standard-of-care arm. Adherence to diet is assessed in both arms using food frequency questionnaires and biomarkers of compliance. The primary endpoint is the change (from baseline to 12 months) in the thickness of the fibrous cap of a non-significant atherosclerotic plaque in a non-culprit vessel, as assessed by repeated optical coherence tomography intracoronary imaging. Indices of coronary vascular physiology and changes in gastrointestinal microbiota, immunological status and protein and metabolite profiles will be evaluated as secondary endpoints. Discussion: The results of this trial will address the key effects of dietary habits on atherosclerotic risk and will provide initial data on the complex interplay of immunological, microbiome-, proteome- and metabolome-related mechanisms by which non-pharmacological factors may impact the progression of coronary atherosclerosis after an ACS.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Atherosclerosis
- Mediterranean diet
- Immune system
- Microbiota
- -Omics
- Randomized controlled trial
- myocardial-infarction
- endothelial dysfunction
- atherosclerotic plaque
- association
- absorption
- mortality
- profile
- design
- score
- Research & Experimental Medicine
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
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Trials
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Till lärosätets databas
- Av författaren/redakt...
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Fernandez, A. I.
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Bermejo, J.
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Yotti, R.
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Martinez-Gonzale ...
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Mira, A.
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Gophna, U.
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visa fler...
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Karlsson, Roger, ...
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Al-Daccak, R.
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Martin-Demiguel, ...
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Gutierrez-Ibanes ...
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Charron, D.
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Fernandez-Aviles ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Näringslära
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
- Artiklar i publikationen
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Trials
- Av lärosätet
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Göteborgs universitet