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Thirty-Day Outcomes...
Thirty-Day Outcomes of Children and Adolescents With COVID-19: An International Experience.
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Duarte-Salles, Talita (author)
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Vizcaya, David (author)
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Pistillo, Andrea (author)
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Casajust, Paula (author)
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Sena, Anthony G (author)
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Lai, Lana Yin Hui (author)
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Prats-Uribe, Albert (author)
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Ahmed, Waheed-Ul-Rahman (author)
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Alshammari, Thamir M (author)
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Alghoul, Heba (author)
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Alser, Osaid (author)
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Burn, Edward (author)
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You, Seng Chan (author)
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Areia, Carlos (author)
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Blacketer, Clair (author)
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DuVall, Scott (author)
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Falconer, Thomas (author)
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Fernandez-Bertolin, Sergio (author)
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Fortin, Stephen (author)
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Golozar, Asieh (author)
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Gong, Mengchun (author)
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Tan, Eng Hooi (author)
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Huser, Vojtech (author)
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Iveli, Pablo (author)
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Morales, Daniel R (author)
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- Nyberg, Fredrik, 1961 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine
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Posada, Jose D (author)
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Recalde, Martina (author)
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Roel, Elena (author)
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Schilling, Lisa M (author)
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Shah, Nigam H (author)
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Shah, Karishma (author)
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Suchard, Marc A (author)
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Zhang, Lin (author)
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Zhang, Ying (author)
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Williams, Andrew E (author)
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Reich, Christian G (author)
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Hripcsak, George (author)
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Rijnbeek, Peter (author)
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Ryan, Patrick (author)
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Kostka, Kristin (author)
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Prieto-Alhambra, Daniel (author)
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(creator_code:org_t)
- 2021-09-01
- 2021
- English.
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In: Pediatrics. - : American Academy of Pediatrics (AAP). - 1098-4275 .- 0031-4005. ; 148:3
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- To characterize the demographics, comorbidities, symptoms, in-hospital treatments, and health outcomes among children and adolescents diagnosed or hospitalized with coronavirus disease 2019 (COVID-19) and to compare them in secondary analyses with patients diagnosed with previous seasonal influenza in 2017-2018.International network cohort using real-world data from European primary care records (France, Germany, and Spain), South Korean claims and US claims, and hospital databases. We included children and adolescents diagnosed and/or hospitalized with COVID-19 at age <18 between January and June 2020. We described baseline demographics, comorbidities, symptoms, 30-day in-hospital treatments, and outcomes including hospitalization, pneumonia, acute respiratory distress syndrome, multisystem inflammatory syndrome in children, and death.A total of 242158 children and adolescents diagnosed and 9769 hospitalized with COVID-19 and 2084180 diagnosed with influenza were studied. Comorbidities including neurodevelopmental disorders, heart disease, and cancer were more common among those hospitalized with versus diagnosed with COVID-19. Dyspnea, bronchiolitis, anosmia, and gastrointestinal symptoms were more common in COVID-19 than influenza. In-hospital prevalent treatments for COVID-19 included repurposed medications (<10%) and adjunctive therapies: systemic corticosteroids (6.8%-7.6%), famotidine (9.0%-28.1%), and antithrombotics such as aspirin (2.0%-21.4%), heparin (2.2%-18.1%), and enoxaparin (2.8%-14.8%). Hospitalization was observed in 0.3% to 1.3% of the cohort diagnosed with COVID-19, with undetectable (n < 5 per database) 30-day fatality. Thirty-day outcomes including pneumonia and hypoxemia were more frequent in COVID-19 than influenza.Despite negligible fatality, complications including hospitalization, hypoxemia, and pneumonia were more frequent in children and adolescents with COVID-19 than with influenza. Dyspnea, anosmia, and gastrointestinal symptoms could help differentiate diagnoses. A wide range of medications was used for the inpatient management of pediatric COVID-19.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Keyword
- Adolescent
- Age Distribution
- COVID-19
- complications
- diagnosis
- drug therapy
- epidemiology
- Child
- Child
- Preschool
- Cohort Studies
- Comorbidity
- Databases
- Factual
- Diagnosis
- Differential
- Female
- France
- epidemiology
- Germany
- epidemiology
- Hospitalization
- statistics & numerical data
- Humans
- Infant
- Infant
- Newborn
- Influenza
- Human
- complications
- diagnosis
- epidemiology
- Male
- Republic of Korea
- epidemiology
- Spain
- epidemiology
- Symptom Assessment
- Time Factors
- Treatment Outcome
- United States
- epidemiology
Publication and Content Type
- ref (subject category)
- art (subject category)
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Pediatrics
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- By the author/editor
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Duarte-Salles, T ...
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Vizcaya, David
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Pistillo, Andrea
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Casajust, Paula
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Sena, Anthony G
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Lai, Lana Yin Hu ...
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show more...
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Prats-Uribe, Alb ...
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Ahmed, Waheed-Ul ...
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Alshammari, Tham ...
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Alghoul, Heba
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Alser, Osaid
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Burn, Edward
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You, Seng Chan
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Areia, Carlos
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Blacketer, Clair
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DuVall, Scott
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Falconer, Thomas
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Fernandez-Bertol ...
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Fortin, Stephen
-
Golozar, Asieh
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Gong, Mengchun
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Tan, Eng Hooi
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Huser, Vojtech
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Iveli, Pablo
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Morales, Daniel ...
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Nyberg, Fredrik, ...
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Posada, Jose D
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Recalde, Martina
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Roel, Elena
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Schilling, Lisa ...
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Shah, Nigam H
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Shah, Karishma
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Suchard, Marc A
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Zhang, Lin
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Zhang, Ying
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Williams, Andrew ...
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Reich, Christian ...
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Hripcsak, George
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Rijnbeek, Peter
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Ryan, Patrick
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Kostka, Kristin
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Prieto-Alhambra, ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Public Health Gl ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Pediatrics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Infectious Medic ...
- Articles in the publication
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Pediatrics
- By the university
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University of Gothenburg