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- Jonsson, Lina,1982Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry (author)
Characterisation of age and polarity at onset in bipolar disorder
- Article/chapterEnglish2021
Publisher, publication year, extent ...
- 2021-08-25
- Royal College of Psychiatrists,2021
Numbers
- LIBRIS-ID:oai:gup.ub.gu.se/311155
- https://gup.ub.gu.se/publication/311155URI
- https://doi.org/10.1192/bjp.2021.102DOI
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-187672URI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:148247662URI
Supplementary language notes
- Language:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- Background Studying phenotypic and genetic characteristics of age at onset (AAO) and polarity at onset (PAO) in bipolar disorder can provide new insights into disease pathology and facilitate the development of screening tools. Aims To examine the genetic architecture of AAO and PAO and their association with bipolar disorder disease characteristics. Method Genome-wide association studies (GWASs) and polygenic score (PGS) analyses of AAO (n = 12 977) and PAO (n = 6773) were conducted in patients with bipolar disorder from 34 cohorts and a replication sample (n = 2237). The association of onset with disease characteristics was investigated in two of these cohorts. Results Earlier AAO was associated with a higher probability of psychotic symptoms, suicidality, lower educational attainment, not living together and fewer episodes. Depressive onset correlated with suicidality and manic onset correlated with delusions and manic episodes. Systematic differences in AAO between cohorts and continents of origin were observed. This was also reflected in single-nucleotide variant-based heritability estimates, with higher heritabilities for stricter onset definitions. Increased PGS for autism spectrum disorder (beta = -0.34 years, s.e. = 0.08), major depression (beta = -0.34 years, s.e. = 0.08), schizophrenia (beta = -0.39 years, s.e. = 0.08), and educational attainment (beta = -0.31 years, s.e. = 0.08) were associated with an earlier AAO. The AAO GWAS identified one significant locus, but this finding did not replicate. Neither GWAS nor PGS analyses yielded significant associations with PAO. Conclusions AAO and PAO are associated with indicators of bipolar disorder severity. Individuals with an earlier onset show an increased polygenic liability for a broad spectrum of psychiatric traits. Systematic differences in AAO across cohorts, continents and phenotype definitions introduce significant heterogeneity, affecting analyses.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Neurovetenskaper hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Neurosciences hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Psykiatri hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Psychiatry hsv//eng
- Bipolar disorder
- age at onset
- polarity at onset
- GWAS
- polygenic score
- genome-wide association
- illness
- genetics
- disease
- family
- loci
- Psychiatry
- Age at onset
Added entries (persons, corporate bodies, meetings, titles ...)
- Landén, Mikael,1966Gothenburg University,Göteborgs universitet,Karolinska Institutet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xlandt (author)
- Vreeker, A. (author)
- McQuillin, A. (author)
- Stahl, E. A. (author)
- Ruderfer, D. (author)
- Grigoroiu-Serbanescu, M. (author)
- Panagiotaropoulou, G. (author)
- Ripke, S. (author)
- Bigdeli, T. B. (author)
- Stein, F. (author)
- Meller, T. (author)
- Meinert, S. (author)
- Pelin, H. (author)
- Streit, F. (author)
- Papiol, S. (author)
- Adams, M. J. (author)
- Adolfsson, RolfUmeå universitet,Psykiatri(Swepub:umu)road0001 (author)
- Adorjan, K. (author)
- Agartz, I.Karolinska Institutet (author)
- Aminoff, S. R. (author)
- Anderson-Schmidt, H. (author)
- Andreassen, O. A. (author)
- Ardau, R. (author)
- Aubry, J. M. (author)
- Balaban, C. (author)
- Bass, N. (author)
- Baune, B. T. (author)
- Bellivier, F. (author)
- Benabarre, A. (author)
- Bengesser, S. (author)
- Berrettini, W. H. (author)
- Boks, M. P. (author)
- Bromet, E. J. (author)
- Brosch, K. (author)
- Budde, M. (author)
- Byerley, W. (author)
- Cervantes, P. (author)
- Chillotti, C. (author)
- Cichon, S. (author)
- Clark, S. R. (author)
- Comes, A. L. (author)
- Corvin, A. (author)
- Coryell, W. (author)
- Craddock, N. (author)
- Craig, D. W. (author)
- Pålsson, Erik,1975Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xpaler (author)
- Cruceanu, C. (author)
- Czerski, P. M. (author)
- Dalkner, N. (author)
- Dannlowski, U. (author)
- Degenhardt, F. (author)
- Del Zompo, M. (author)
- DePaulo, J. R. (author)
- Djurovic, S. (author)
- Edenberg, H. J. (author)
- Al Eissa, M. (author)
- Elvsashagen, T. (author)
- Etain, B. (author)
- Fanous, A. H. (author)
- Fellendorf, F. (author)
- Fiorentino, A. (author)
- Forstner, A. J. (author)
- Frye, M. A. (author)
- Fullerton, J. M. (author)
- Gade, K. (author)
- Garnham, J. (author)
- Gershon, E. (author)
- Gill, M. (author)
- Goes, F. S. (author)
- Gordon-Smith, K. (author)
- Grof, P. (author)
- Guzman-Parra, J. (author)
- Hahn, T. (author)
- Hasler, R. (author)
- Heilbronner, M. (author)
- Heilbronner, U. (author)
- Jamain, S. (author)
- Jimenez, E. (author)
- Jones, I. (author)
- Jones, L. (author)
- Jonsson, Lina,1982Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xjliny (author)
- Kahn, R. S. (author)
- Kelsoe, J. R. (author)
- Kennedy, J. L. (author)
- Kircher, T. (author)
- Kirov, G. (author)
- Kittel-Schneider, S. (author)
- Klohn-Saghatolislam, F. (author)
- Knowles, J. A. (author)
- Kranz, T. M. (author)
- Lagerberg, T. V. (author)
- Landén, Mikael,1966Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xlandt (author)
- Lawson, W. B. (author)
- Leboyer, M. (author)
- Li, Q. Q. S. (author)
- Maj, M. (author)
- Malaspina, D. (author)
- Manchia, M. (author)
- Mayoral, F. (author)
- McElroy, S. L. (author)
- McInnis, M. G. (author)
- McIntosh, A. M. (author)
- Medeiros, H. (author)
- Melle, I. (author)
- Milanova, V. (author)
- Mitchell, P. B. (author)
- Monteleone, P. (author)
- Monteleone, A. M. (author)
- Nothen, M. M. (author)
- Novak, T. (author)
- Nurnberger, J. I. (author)
- O'Brien, N. (author)
- O'Connell, K. S. (author)
- O'Donovan, C. (author)
- O'Donovan, M. C. (author)
- Opel, N. (author)
- Ortiz, A. (author)
- Owen, M. J. (author)
- Pålsson, Erik,1975Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xpaler (author)
- Pato, C. (author)
- Pato, M. T. (author)
- Pawlak, J. (author)
- Pfarr, J. K. (author)
- Pisanu, C. (author)
- Potash, J. B. (author)
- Rapaport, M. H. (author)
- Reich-Erkelenz, D. (author)
- Reif, A. (author)
- Reininghaus, E. (author)
- Repple, J. (author)
- Richard-Lepouriel, H. (author)
- Rietschel, M. (author)
- Ringwald, K. (author)
- Roberts, G. (author)
- Rouleau, G. (author)
- Schaupp, S. (author)
- Scheftner, W. A. (author)
- Schmitt, S. (author)
- Schofield, P. R. (author)
- Schubert, K. O. (author)
- Schulte, E. C. (author)
- Schweizer, B. (author)
- Senner, F. (author)
- Severino, G. (author)
- Sharp, S. (author)
- Slaney, C. (author)
- Smeland, O. B. (author)
- Sobell, J. L. (author)
- Squassina, A. (author)
- Stopkova, P. (author)
- Strauss, J. (author)
- Tortorella, A. (author)
- Turecki, G. (author)
- Twarowska-Hauser, J. (author)
- Veldic, M. (author)
- Vieta, E. (author)
- Vincent, J. B. (author)
- Xu, W. (author)
- Zai, C. C. (author)
- Zandi, P. P. (author)
- Di Florio, A. (author)
- Smoller, J. W. (author)
- Biernacka, J. M. (author)
- McMahon, F. J. (author)
- Alda, M. (author)
- Muller-Myhsok, B. (author)
- Koutsouleris, N. (author)
- Falkai, P. (author)
- Freimer, N. B. (author)
- Andlauer, T. F. M. (author)
- Schulze, T. G. (author)
- Ophoff, R. A. (author)
- Göteborgs universitetInstitutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi (creator_code:org_t)
Related titles
- In:British Journal of Psychiatry: Royal College of Psychiatrists219:6, s. 659-6690007-12501472-1465
Internet link
- https://www.cambridge.org/core/services/aop-cambridge-core/content/view/DBFE4929435DBD6D75BC546201BC4BA1/S0007125021001021a.pdf/div-class-title-characterisation-of-age-and-polarity-at-onset-in-bipolar-disorder-div.pdf
- https://doi.org/10.1192/bjp.2021.102Fulltext
- https://umu.diva-portal.org/smash/get/diva2:1595817/FULLTEXT02.pdffulltext:print
- https://gup.ub.gu.se/publication/311155
- https://doi.org/10.1192/bjp.2021.102
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-187672
- http://kipublications.ki.se/Default.aspx?queryparsed=id:148247662
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