Search: ((WFRF:(Heitz F)) srt2:(2020-2024)) >
MCM3 is a novel pro...
MCM3 is a novel proliferation marker associated with longer survival for patients with tubo-ovarian high-grade serous carcinoma
- Article/chapterEnglish2022
Publisher, publication year, extent ...
-
2021-11-15
-
Springer Science and Business Media LLC,2022
Numbers
-
LIBRIS-ID:oai:gup.ub.gu.se/311491
-
https://gup.ub.gu.se/publication/311491URI
-
https://doi.org/10.1007/s00428-021-03232-0DOI
Supplementary language notes
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
Tubo-ovarian high-grade serous carcinomas (HGSC) are highly proliferative neoplasms that generally respond well to platinum/taxane chemotherapy. We recently identified minichromosome maintenance complex component 3 (MCM3), which is involved in the initiation of DNA replication and proliferation, as a favorable prognostic marker in HGSC. Our objective was to further validate whether MCM3 mRNA expression and possibly MCM3 protein levels are associated with survival in patients with HGSC. MCM3 mRNA expression was measured using NanoString expression profiling on formalin-fixed and paraffin-embedded tissue (N = 2355 HGSC) and MCM3 protein expression was assessed by immunohistochemistry (N = 522 HGSC) and compared with Ki-67. Kaplan-Meier curves and the Cox proportional hazards model were used to estimate associations with survival. Among chemotherapy-naive HGSC, higher MCM3 mRNA expression (one standard deviation increase in the score) was associated with longer overall survival (HR = 0.87, 95% CI 0.81-0.92, p < 0.0001, N = 1840) in multivariable analysis. MCM3 mRNA expression was highest in the HGSC C5.PRO molecular subtype, although no interaction was observed between MCM3, survival and molecular subtypes. MCM3 and Ki-67 protein levels were significantly lower after exposure to neoadjuvant chemotherapy compared to chemotherapy-naive tumors: 37.0% versus 46.4% and 22.9% versus 34.2%, respectively. Among chemotherapy-naive HGSC, high MCM3 protein levels were also associated with significantly longer disease-specific survival (HR = 0.52, 95% CI 0.36-0.74, p = 0.0003, N = 392) compared to cases with low MCM3 protein levels in multivariable analysis. MCM3 immunohistochemistry is a promising surrogate marker of proliferation in HGSC.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Millstein, J.
(author)
-
Popovic, G.
(author)
-
Meagher, N. S.
(author)
-
Bolithon, A.
(author)
-
Talhouk, A.
(author)
-
Chiu, D. S.
(author)
-
Anglesio, M. S.
(author)
-
Leung, B.
(author)
-
Tang, K.
(author)
-
Lambie, N.
(author)
-
Pavanello, M.
(author)
-
Da-Anoy, A.
(author)
-
Lambrechts, D.
(author)
-
Loverix, L.
(author)
-
Olbrecht, S.
(author)
-
Bisinotto, C.
(author)
-
Garcia-Donas, J.
(author)
-
Ruiz-Llorente, S.
(author)
-
Yague-Fernandez, M.
(author)
-
Edwards, R. P.
(author)
-
Elishaev, E.
(author)
-
Olawaiye, A.
(author)
-
Taylor, S.
(author)
-
Ataseven, B.
(author)
-
du Bois, A.
(author)
-
Harter, P.
(author)
-
Lester, J.
(author)
-
Hogdall, C. K.
(author)
-
Armasu, S. M.
(author)
-
Huang, Y. J.
(author)
-
Vierkant, R. A.
(author)
-
Wang, C.
(author)
-
Winham, S. J.
(author)
-
Heublein, S.
(author)
-
Kommoss, F. K. F.
(author)
-
Cramer, D. W.
(author)
-
Sasamoto, N.
(author)
-
Van-Wagensveld, L.
(author)
-
Lycke, MariaGothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology(Swepub:gu)xlycma
(author)
-
Mateoiu, ConstantinaGothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institute of Biomedicine
(author)
-
Joseph, J.
(author)
-
Pike, M. C.
(author)
-
Odunsi, K.
(author)
-
Tseng, C. C.
(author)
-
Pearce, C. L.
(author)
-
Bilic, S.
(author)
-
Conrads, T. P.
(author)
-
Hartmann, A.
(author)
-
Hein, A.
(author)
-
Jones, M. E.
(author)
-
Leung, Y.
(author)
-
Beckmann, M. W.
(author)
-
Ruebner, M.
(author)
-
Schoemaker, M. J.
(author)
-
Terry, K. L.
(author)
-
El-Bahrawy, M. A.
(author)
-
Coulson, P.
(author)
-
Etter, J. L.
(author)
-
LaVigne-Mager, K.
(author)
-
Andress, J.
(author)
-
Grube, M.
(author)
-
Fischer, A.
(author)
-
Neudeck, N.
(author)
-
Robertson, G.
(author)
-
Farrell, R.
(author)
-
Barlow, E.
(author)
-
Quinn, C.
(author)
-
Hettiaratchi, A.
(author)
-
Casablanca, Y.
(author)
-
Erber, R.
(author)
-
Stewart, C. J. R.
(author)
-
Tan, A.
(author)
-
Yu, Y.
(author)
-
Boros, J.
(author)
-
Brand, A. H.
(author)
-
Harnett, P. R.
(author)
-
Kennedy, C. J.
(author)
-
Nevins, N.
(author)
-
Morgan, T.
(author)
-
Fasching, P. A.
(author)
-
Vergote, I.
(author)
-
Swerdlow, A. J.
(author)
-
Dos Reis, F. J. C.
(author)
-
Maxwell, G. L.
(author)
-
Neuhausen, S. L.
(author)
-
Barquin-Garcia, A.
(author)
-
Modugno, F.
(author)
-
Moysich, K. B.
(author)
-
Crowe, P. J.
(author)
-
Hirasawa, A.
(author)
-
Heitz, F.
(author)
-
Karlan, B. Y.
(author)
-
Goode, E. L.
(author)
-
Sinn, P.
(author)
-
Horlings, H. M.
(author)
-
Hogdall, E.
(author)
-
Sundfeldt, Karin,1962Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology(Swepub:gu)xsukar
(author)
-
Kommoss, S.
(author)
-
Staebler, A.
(author)
-
Wu, A. H.
(author)
-
Cohen, P. A.
(author)
-
DeFazio, A.
(author)
-
Lee, C. H.
(author)
-
Steed, H.
(author)
-
Le, N. D.
(author)
-
Gayther, S. A.
(author)
-
Lawrenson, K.
(author)
-
Pharoah, P. D. P.
(author)
-
Konecny, G.
(author)
-
Cook, L. S.
(author)
-
Ramus, S. J.
(author)
-
Kelemen, L. E.
(author)
-
Kobel, M.
(author)
-
Göteborgs universitetInstitutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi
(creator_code:org_t)
Related titles
-
In:Virchows Archiv: Springer Science and Business Media LLC480, s. 855-8710945-63171432-2307
Internet link
Find in a library
To the university's database
- By the author/editor
-
Kang, E. Y.
-
Millstein, J.
-
Popovic, G.
-
Meagher, N. S.
-
Bolithon, A.
-
Talhouk, A.
-
show more...
-
Chiu, D. S.
-
Anglesio, M. S.
-
Leung, B.
-
Tang, K.
-
Lambie, N.
-
Pavanello, M.
-
Da-Anoy, A.
-
Lambrechts, D.
-
Loverix, L.
-
Olbrecht, S.
-
Bisinotto, C.
-
Garcia-Donas, J.
-
Ruiz-Llorente, S ...
-
Yague-Fernandez, ...
-
Edwards, R. P.
-
Elishaev, E.
-
Olawaiye, A.
-
Taylor, S.
-
Ataseven, B.
-
du Bois, A.
-
Harter, P.
-
Lester, J.
-
Hogdall, C. K.
-
Armasu, S. M.
-
Huang, Y. J.
-
Vierkant, R. A.
-
Wang, C.
-
Winham, S. J.
-
Heublein, S.
-
Kommoss, F. K. F ...
-
Cramer, D. W.
-
Sasamoto, N.
-
Van-Wagensveld, ...
-
Lycke, Maria
-
Mateoiu, Constan ...
-
Joseph, J.
-
Pike, M. C.
-
Odunsi, K.
-
Tseng, C. C.
-
Pearce, C. L.
-
Bilic, S.
-
Conrads, T. P.
-
Hartmann, A.
-
Hein, A.
-
Jones, M. E.
-
Leung, Y.
-
Beckmann, M. W.
-
Ruebner, M.
-
Schoemaker, M. J ...
-
Terry, K. L.
-
El-Bahrawy, M. A ...
-
Coulson, P.
-
Etter, J. L.
-
LaVigne-Mager, K ...
-
Andress, J.
-
Grube, M.
-
Fischer, A.
-
Neudeck, N.
-
Robertson, G.
-
Farrell, R.
-
Barlow, E.
-
Quinn, C.
-
Hettiaratchi, A.
-
Casablanca, Y.
-
Erber, R.
-
Stewart, C. J. R ...
-
Tan, A.
-
Yu, Y.
-
Boros, J.
-
Brand, A. H.
-
Harnett, P. R.
-
Kennedy, C. J.
-
Nevins, N.
-
Morgan, T.
-
Fasching, P. A.
-
Vergote, I.
-
Swerdlow, A. J.
-
Dos Reis, F. J. ...
-
Maxwell, G. L.
-
Neuhausen, S. L.
-
Barquin-Garcia, ...
-
Modugno, F.
-
Moysich, K. B.
-
Crowe, P. J.
-
Hirasawa, A.
-
Heitz, F.
-
Karlan, B. Y.
-
Goode, E. L.
-
Sinn, P.
-
Horlings, H. M.
-
Hogdall, E.
-
Sundfeldt, Karin ...
-
Kommoss, S.
-
Staebler, A.
-
Wu, A. H.
-
Cohen, P. A.
-
DeFazio, A.
-
Lee, C. H.
-
Steed, H.
-
Le, N. D.
-
Gayther, S. A.
-
Lawrenson, K.
-
Pharoah, P. D. P ...
-
Konecny, G.
-
Cook, L. S.
-
Ramus, S. J.
-
Kelemen, L. E.
-
Kobel, M.
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Cell and Molecul ...
- Articles in the publication
-
Virchows Archiv
- By the university
-
University of Gothenburg