Molecular Response to Nanopatterned Implants in the Human Jaw Bone

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Karazisis, Dimitrios,1977Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap,Institute of Clinical Sciences, Department of Biomaterials,University of Gothenburg, Sweden,Univ Gothenburg, Sweden; Univ Gothenburg, Sweden (author)

Molecular Response to Nanopatterned Implants in the Human Jaw Bone

Article/chapterEnglish2021

Publisher, publication year, extent ...

2021-12-01
American Chemical Society (ACS),2021

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LIBRIS-ID:oai:gup.ub.gu.se/312165
https://gup.ub.gu.se/publication/312165URI
https://doi.org/10.1021/acsbiomaterials.1c00861DOI
https://urn.kb.se/resolve?urn=urn:nbn:se:ri:diva-57561URI
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-181772URI

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Language:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Funding Agencies|Swedish Research CouncilSwedish Research CouncilEuropean Commission [2018-02891]; BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy; Vastra Gotaland Region; Swedish government [ALFGBG-725641]; Swedish county councils, the ALF agreement [ALFGBG-725641]; TUA/Region Vastra Gotaland; Stiftelsen Handlanden Hjalmar Svensson; IngaBritt and Arne Lundberg Foundation; Eivind o Elsa K: son Sylvan Foundation; Area of Advance Materials of Chalmers and GU Biomaterials within the Strategic Research Area initiative
Implant surface modification by nanopatterning is an interesting route for enhancing osseointegration in humans. Herein, the molecular response to an intentional, controlled nanotopography pattern superimposed on screw-shaped titanium implants is investigated in human bone. When clinical implants are installed, additional two mini-implants, one with a machined surface (M) and one with a machined surface superimposed with a hemispherical nanopattern (MN), are installed in the posterior maxilla. In the second-stage surgery, after 6-8 weeks, the mini-implants are retrieved by unscrewing, and the implant-adherent cells are subjected to gene expression analysis using quantitative polymerase chain reaction (qPCR). Compared to those adherent to the machined (M) implants, the cells adherent to the nanopatterned (MN) implants demonstrate significant upregulation (1.8- to 2-fold) of bone-related genes (RUNX2, ALP, and OC). No significant differences are observed in the expression of the analyzed inflammatory and remodeling genes. Correlation analysis reveals that older patient age is associated with increased expression of proinflammatory cytokines (TNF-alpha and MCP-1) on the machined implants and decreased expression of proosteogenic factor (BMP-2) on the nanopatterned implants. Controlled nanotopography, in the form of hemispherical 60 nm protrusions, promotes gene expressions related to early osteogenic differentiation and osteoblastic activity in implant-adherent cells in the human jaw bone.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Medicinsk bioteknologi Biomaterialvetenskap hsv//swe
MEDICAL AND HEALTH SCIENCES Medical Biotechnology Biomaterials Science hsv//eng
TEKNIK OCH TEKNOLOGIER Medicinteknik Medicinsk material- och protesteknik hsv//swe
ENGINEERING AND TECHNOLOGY Medical Engineering Medical Materials hsv//eng
osseointegration
nanomedicine
nanotopography
gene expression
osteogenic activities
human jaw
well-defined nanotopography
titanium-dioxide nanotubes
gene-expression
follow-up
in-vivo
different diameters
dental
implants
tio2 nanotubes
osseointegration
surfaces
Materials Science
gene expression

Added entries (persons, corporate bodies, meetings, titles ...)

Omar, O.Imam Abdulrahman Bin Faisal University, Saudi Arabia,Imam Abdulrahman bin Faisal Univ, Saudi Arabia (author)
Petronis, SarunasRISE,Metodik för produktframtagning,RISE Res Inst Sweden, Sweden(Swepub:ri)sarunaspe@ri.se (author)
Thomsen, Peter,1953Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap,Institute of Clinical Sciences, Department of Biomaterials,University of Gothenburg, Sweden,Univ Gothenburg, Sweden(Swepub:gu)xthope (author)
Rasmusson, Lars,1962Linköpings universitet,Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap,Institutionen för odontologi, sektion 1,Institute of Clinical Sciences, Department of Biomaterials,Institute of Odontology, Section 1,University of Gothenburg, Sweden; Linköping University Hospital, Sweden,Avdelningen för sinnesorgan och kommunikation,Medicinska fakulteten,Region Östergötland, Käkkliniken US,Univ Gothenburg, Sweden; Univ Gothenburg, Sweden(Swepub:liu)larra35 (author)
Göteborgs universitetInstitutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap (creator_code:org_t)

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In:Acs Biomaterials Science & Engineering: American Chemical Society (ACS)7:12, s. 5878-58892373-9878

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