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  • Liu, S. X.Karolinska Institutet (author)

Neurodevelopmental Disorders, Glycemic Control, and Diabetic Complications in Type 1 Diabetes: a Nationwide Cohort Study

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • 2021-06-25
  • Cary, NC :The Endocrine Society,2021

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/312197
  • https://gup.ub.gu.se/publication/312197URI
  • https://doi.org/10.1210/clinem/dgab467DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-92681URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-45915URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:148146576URI

Supplementary language notes

  • Language:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding agency:Karolinska Institutet, Strategic Research Program in Neuroscience (StratNeuro)
  • Funding: The Swedish Research Council (No 2017-00788), Stockholm Region Council (No 20180718) and Karolinska Institutet, Strategic Research Program in Neuroscience (StratNeuro).
  • Context: Neurodevelopmental disorders are more prevalent in childhood-onset type 1 diabetes than in the general population, and the symptoms may limit the individual's ability for diabetes management. Objective: This study investigated whether comorbid neurodevelopmental disorders are associated with long-term glycemic control and risk of diabetic complications. Methods: This population-based cohort study used longitudinally collected data from Swedish registers. We identified 11 326 individuals born during 1973-2013, diagnosed with type 1 diabetes during 1990-2013 (median onset age: 9.6 years). Among them, 764 had a comorbid neurodevelopmental disorder, including attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder, and intellectual disability. We used multinomial logistic regression to calculate odds ratios (ORs) of having poor glycemic control (assessed by glycated hemoglobin [HbA(1c)]) and Cox regression to estimate hazard ratios (HRs) of nephropathy and retinopathy. Results: The median follow-up was 7.5 years (interquartile range [IQR] 3.9, 11.2). Having any neurodevelopmental disorder (ORadjusted 1.51 [95% CI 1.13, 2.03]), or ADHD (ORadjusted 2.31 [95% CI 1.54, 3.45]) was associated with poor glycemic control (mean HbA(1c) > 8.5%). Increased risk of diabetic complications was observed in patients with comorbid neurodevelopmental disorders (HRadjusted 1.72 [95% CI 1.21, 2.44] for nephropathy, HRadjusted 1.18 [95% CI 1.00, 1.40] for retinopathy) and patients with ADHD (HRadjusted 1.90 [95% CI 1.20, 3.00] for nephropathy, HRadjusted 1.33 [95% CI 1.07, 1.66] for retinopathy). Patients with intellectual disability have a particularly higher risk of nephropathy (HRadjusted 2.64 [95% CI 1.30, 5.37]). Conclusion: Comorbid neurodevelopmental disorders, primarily ADHD and intellectual disability, were associated with poor glycemic control and a higher risk of diabetic complications in childhood-onset type 1 diabetes.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Kuja-Halkola, R.Karolinska Institutet (author)
  • Larsson, Henrik,1975-Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Solna, Sweden; School of Medical Sciences, Örebro University, Örebro, Sweden(Swepub:oru)hiln (author)
  • Lichtenstein, P.Karolinska Institutet (author)
  • Ludvigsson, Jonas F.,1969-Karolinska Institutet(Swepub:oru)jsln (author)
  • Svensson, Ann-Marie,1961Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Swedish National Diabetes Register, Centre of Registers, Gothenburg, Sweden; School of Health and Social Science, Halmstad University, Halmstad, Sweden,Swedish National Diabetes Register, Centre of Registers, Gothenburg, Sweden; Department of Molecular and Clinical Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden(Swepub:gu)xsannh (author)
  • Gudbjörnsdottir, Soffia,1962Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Swedish National Diabetes Register, Centre of Registers, Gothenburg, Sweden; Department of Molecular and Clinical Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden(Swepub:gu)xgudso (author)
  • Tideman, Magnus,1959-Högskolan i Halmstad,Wigforss-gruppen(Swepub:hh)mati (author)
  • Serlachius, E.Karolinska Institutet (author)
  • Butwicka, A.Karolinska Institutet (author)
  • Karolinska InstitutetInstitutionen för medicinska vetenskaper (creator_code:org_t)

Related titles

  • In:Journal of Clinical Endocrinology & MetabolismCary, NC : The Endocrine Society106:110021-972X1945-7197

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