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Predicting progress...
Predicting progression to dementia in persons with mild cognitive impairment using cerebrospinal fluid markers
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- Handels, Ron L. H. (author)
- Department of Psychiatry and Neuropsychology, Alzheimer Centre Limburg, School for Mental Health and Neurosciences, Maastricht University, Maastricht, The Netherlands,Paris-Sorbonne University
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- Vos, Stephanie J. B. (author)
- Karolinska Institutet,Maastricht University
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- Kramberger, Milica G. (author)
- Department of Neurology, Ljubljana University Medical Centre, Ljubljana, Slovenia
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- Jelic, Vesna (author)
- Karolinska Institutet
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- Blennow, Kaj (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- van Buchem, Mark (author)
- Department of Radiology, Leiden University Medical Centre, Leiden, The Netherlands
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- van der Flier, Wiesje (author)
- Alzheimer Centre and Department of Neurology, Neuroscience Campus Amsterdam, VU University Medical Centre, Amsterdam, The Netherlands; Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, The Netherlands,Amsterdam UMC - Vrije Universiteit Amsterdam
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- Freund-Levi, Yvonne, 1956- (author)
- Karolinska Institutet
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- Hampel, Harald (author)
- AXA Research Fund & UPMC Chair, Paris, France; Sorbonne Universités Pierre et Marie Curie (UPMC) Paris 06, Inserm, CNRS, Institut du cerveau et de la moelle (ICM), Département de Neurologie, Institut de la Mémoire et de la Maladie d'Alzheimer (IM2A), Hôpital Pitié-Salpêtrière, Paris, France
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- Olde Rikkert, Marcel (author)
- Department of Geriatrics, Radboudumc Alzheimer Centre, Donders Institute for Brain Cognition and Behavior, Radboud University Medical Centre, Nijmegen, The Netherlands
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- Oleksik, Ania (author)
- Department of Radiology, Leiden University Medical Centre, Leiden, The Netherlands
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- Pirtosek, Zvezdan (author)
- Department of Neurology, Ljubljana University Medical Centre, Ljubljana, Slovenia
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- Scheltens, Philip (author)
- Alzheimer Centre and Department of Neurology, Neuroscience Campus Amsterdam, VU University Medical Centre, Amsterdam, The Netherlands,Amsterdam UMC - Vrije Universiteit Amsterdam
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- Soininen, Hilkka (author)
- Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Neurocenter–Neurology, Kuopio University Hospital, Kuopio, Finland
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- Teunissen, Charlotte (author)
- Neurochemistry Laboratory and Biobank, Department of Clinical Chemistry, VU University Medical Centre, Amsterdam, The Netherlands,Amsterdam UMC - Vrije Universiteit Amsterdam
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- Tsolaki, Magda (author)
- Memory and Dementia Outpatient Clinic, 3rd Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece
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- Wallin, Asa K. (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups
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- Winblad, Bengt (author)
- Karolinska Institutet
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- Verhey, Frans R. J. (author)
- Department of Psychiatry and Neuropsychology, Alzheimer Centre Limburg, School for Mental Health and Neurosciences, Maastricht University, Maastricht, The Netherlands
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- Visser, Pieter Jelle (author)
- Department of Psychiatry and Neuropsychology, Alzheimer Centre Limburg, School for Mental Health and Neurosciences, Maastricht University, Maastricht, The Netherlands; Alzheimer Centre and Department of Neurology, Neuroscience Campus Amsterdam, VU University Medical Centre, Amsterdam, The Netherlands,Amsterdam UMC - Vrije Universiteit Amsterdam
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(creator_code:org_t)
- 2017-02-16
- 2017
- English.
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In: Alzheimer's & Dementia. - : Elsevier. - 1552-5260 .- 1552-5279. ; 13:8, s. 903-912
- Related links:
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http://dx.doi.org/10...
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Abstract
Subject headings
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- INTRODUCTION: We aimed to determine the added value of cerebrospinal fluid (CSF) to clinical and imaging tests to predict progression from mild cognitive impairment (MCI) to any type of dementia.METHODS: The risk of progression to dementia was estimated using two logistic regression models based on 250 MCI participants: the first included standard clinical measures (demographic, clinical, and imaging test information) without CSF biomarkers, and the second included standard clinical measures with CSF biomarkers.RESULTS: Adding CSF improved predictive accuracy with 0.11 (scale from 0-1). Of all participants, 136 (54%) had a change in risk score of 0.10 or higher (which was considered clinically relevant), of whom in 101, it was in agreement with their dementia status at follow-up.DISCUSSION: An individual person's risk of progression from MCI to dementia can be improved by relying on CSF biomarkers in addition to recommended clinical and imaging tests for usual care.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Alzheimer's disease
- Conversion
- Dementia
- Mild cognitive impairment
- Predict
- Prognosis
- Progression
- Reclassification
- Risk
- Risk prediction model
- Alzheimer's disease
- Conversion
- Dementia
- Mild cognitive impairment
- Predict
- Prognosis
- Progression
- Reclassification
- Risk
- Risk prediction model
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Handels, Ron L. ...
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Vos, Stephanie J ...
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Kramberger, Mili ...
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Jelic, Vesna
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Blennow, Kaj
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van Buchem, Mark
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van der Flier, W ...
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Freund-Levi, Yvo ...
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Hampel, Harald
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Olde Rikkert, Ma ...
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Oleksik, Ania
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Pirtosek, Zvezda ...
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Scheltens, Phili ...
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Soininen, Hilkka
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Teunissen, Charl ...
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Tsolaki, Magda
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Wallin, Asa K.
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Winblad, Bengt
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Verhey, Frans R. ...
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Visser, Pieter J ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Geriatrics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Alzheimer's & De ...
- By the university
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Örebro University
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Karolinska Institutet
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Lund University
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University of Gothenburg