Search: id:"swepub:oai:gup.ub.gu.se/313347" >
Concentration of st...
-
He, XiulanGothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology
(author)
Concentration of stimulant regulates initial exocytotic molecular plasticity at single cells
- Article/chapterEnglish2022
Publisher, publication year, extent ...
-
2022
-
Royal Society of Chemistry (RSC),2022
Numbers
-
LIBRIS-ID:oai:gup.ub.gu.se/313347
-
https://gup.ub.gu.se/publication/313347URI
-
https://doi.org/10.1039/d1sc05278kDOI
Supplementary language notes
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
Activity-induced synaptic plasticity has been intensively studied, but is not yet well understood. We examined the temporal and concentration effects of exocytotic molecular plasticity during and immediately after chemical stimulation (30 s K+ stimulation) via single cell amperometry. Here the first and the second 15 s event periods from individual event traces were compared. Remarkably, we found that the amount of catecholamine release and release dynamics depend on the stimulant concentration. No changes were observed at 10 mM K+ stimulation, but changes observed at 30 and 50 mM (i.e., potentiation, increased number of molecules) were opposite to those at 100 mM (i.e., depression, decreased number of events), revealing changes in exocytotic plasticity based on the concentration of the stimulant solution. These results show that molecular changes initiating exocytotic plasticity can be regulated by the concentration strength of the stimulant solution. These different effects on early plasticity offer a possible link between stimulation intensity and synaptic (or adrenal) plasticity.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Ewing, Andrew G,1957Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology(Swepub:gu)xewian
(author)
-
Göteborgs universitetInstitutionen för kemi och molekylärbiologi
(creator_code:org_t)
Related titles
-
In:Chemical Science: Royal Society of Chemistry (RSC)13, s. 1815-18222041-65202041-6539
Internet link
Find in a library
To the university's database