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  • Belda, E.Sorbonne Université,Sorbonne University (author)

Impairment of gut microbial biotin metabolism and host biotin status in severe obesity: effect of biotin and prebiotic supplementation on improved metabolism

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • 2022-01-11
  • BMJ,2022

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/313369
  • https://gup.ub.gu.se/publication/313369URI
  • https://doi.org/10.1136/gutjnl-2021-325753DOI
  • https://research.chalmers.se/publication/528402URI

Supplementary language notes

  • Language:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Objectives Gut microbiota is a key component in obesity and type 2 diabetes, yet mechanisms and metabolites central to this interaction remain unclear. We examined the human gut microbiome's functional composition in healthy metabolic state and the most severe states of obesity and type 2 diabetes within the MetaCardis cohort. We focused on the role of B vitamins and B7/B8 biotin for regulation of host metabolic state, as these vitamins influence both microbial function and host metabolism and inflammation. Design We performed metagenomic analyses in 1545 subjects from the MetaCardis cohorts and different murine experiments, including germ-free and antibiotic treated animals, faecal microbiota transfer, bariatric surgery and supplementation with biotin and prebiotics in mice. Results Severe obesity is associated with an absolute deficiency in bacterial biotin producers and transporters, whose abundances correlate with host metabolic and inflammatory phenotypes. We found suboptimal circulating biotin levels in severe obesity and altered expression of biotin-associated genes in human adipose tissue. In mice, the absence or depletion of gut microbiota by antibiotics confirmed the microbial contribution to host biotin levels. Bariatric surgery, which improves metabolism and inflammation, associates with increased bacterial biotin producers and improved host systemic biotin in humans and mice. Finally, supplementing high-fat diet-fed mice with fructo-oligosaccharides and biotin improves not only the microbiome diversity, but also the potential of bacterial production of biotin and B vitamins, while limiting weight gain and glycaemic deterioration. Conclusion Strategies combining biotin and prebiotic supplementation could help prevent the deterioration of metabolic states in severe obesity.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Voland, L.Sorbonne Université,Sorbonne University (author)
  • Tremaroli, Valentina,1978Gothenburg University,Göteborgs universitet,Center for Cardiovascular and Metabolic Research (CMR),Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberglaboratoriet,Institute of Medicine, Department of Molecular and Clinical Medicine,Wallenberg Laboratory,University of Gothenburg(Swepub:gu)xtreva (author)
  • Falony, G.VIB,Katholieke Universiteit Leuven (author)
  • Adriouch, S.Sorbonne Université,Sorbonne University (author)
  • Assmann, K. E.Sorbonne Université,Sorbonne University (author)
  • Prifiti, E.Sorbonne Université,Sorbonne University (author)
  • Aron-Wisnewsky, J.Sorbonne Université,Sorbonne University,Hôpital de la Salpêtrière (author)
  • Debedat, J.Sorbonne Université,Sorbonne University (author)
  • Le Roy, T.Sorbonne Université,Sorbonne University (author)
  • Nielsen, T.Köpenhamns universitet,University of Copenhagen (author)
  • Amouyal, C.Sorbonne Université,Sorbonne University (author)
  • Andre, S.Sorbonne Université,Sorbonne University (author)
  • Andreelli, F.Sorbonne Université,Sorbonne University (author)
  • Bluher, M.Universität Leipzig,Leipzig University (author)
  • Chakaroun, R.Universität Leipzig,Leipzig University (author)
  • Chilloux, J.Imperial College of Science, Technology and Medicine (author)
  • Coelho, L. P.European Molecular Biology Laboratory,Sorbonne Université,Sorbonne University (author)
  • Dao, M. C.Sorbonne Université,Sorbonne University (author)
  • Das, Promi,1990Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)promi (author)
  • Fellahi, S.Sorbonne Université,Sorbonne University,Assistance publique – Hôpitaux de Paris (AP-HP) (author)
  • Forslund, S.Max Delbrueck Centrum Fuer Molekulare Medizin,The Max Delbrück Center for Molecular Medicine (author)
  • Galleron, N.Université Paris-Saclay,University Paris-Saclay (author)
  • Hansen, T. H.Köpenhamns universitet,University of Copenhagen,Syddansk Universitet,University of Southern Denmark (author)
  • Holmes, B.Danone Nutricia Research (author)
  • Ji, Boyang,1983Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)bojand (author)
  • Pedersen, H. K.Köpenhamns universitet,University of Copenhagen (author)
  • Le, P. (author)
  • Le Chatelier, E.Université Paris-Saclay,University Paris-Saclay (author)
  • Lewinter, C.Rigshospitalet (author)
  • Mannerås Holm, Louise,1980Gothenburg University,Göteborgs universitet,Center for Cardiovascular and Metabolic Research (CMR),Wallenberglaboratoriet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberg Laboratory,Institute of Medicine, Department of Molecular and Clinical Medicine,University of Gothenburg(Swepub:gu)xmanlo (author)
  • Marquet, F.Sorbonne Université,Sorbonne University (author)
  • Myridakis, A.Imperial College of Science, Technology and Medicine (author)
  • Pelloux, V.Sorbonne Université,Sorbonne University (author)
  • Pons, N.Université Paris-Saclay,University Paris-Saclay (author)
  • Quinquis, B.Université Paris-Saclay,University Paris-Saclay (author)
  • Rouault, C.Sorbonne Université,Sorbonne University (author)
  • Roume, H.Université Paris-Saclay,University Paris-Saclay (author)
  • Salem, J. E.Hôpital de la Salpêtrière (author)
  • Sokolovska, N.Sorbonne Université,Sorbonne University (author)
  • Sondertoft, N. B.Köpenhamns universitet,University of Copenhagen (author)
  • Touch, S.Sorbonne Université,Sorbonne University (author)
  • Vieira-Silva, S.VIB,Katholieke Universiteit Leuven (author)
  • Galan, P.Université Sorbonne Paris North (author)
  • Holst, J.Köpenhamns universitet,University of Copenhagen (author)
  • Gotze, J. P.Rigshospitalet (author)
  • Kober, L.Rigshospitalet (author)
  • Vestergaard, H.Steno Diabetes Center,Köpenhamns universitet,University of Copenhagen (author)
  • Hansen, T. (author)
  • Hercberg, S.Université Sorbonne Paris North (author)
  • Oppert, J. M.Hôpital de la Salpêtrière (author)
  • Nielsen, Jens B,1962Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)nielsenj (author)
  • Letunic, I.Biobyte Solutions GmbH (author)
  • Dumas, M. E.Imperial College of Science, Technology and Medicine (author)
  • Stumvoll, M.Universität Leipzig,Leipzig University (author)
  • Pedersen, O. B.Köpenhamns universitet,University of Copenhagen (author)
  • Bork, P.European Molecular Biology Laboratory (author)
  • Ehrlich, S. D.King's College London,Université Paris-Saclay,University Paris-Saclay (author)
  • Zucker, J. D.Sorbonne Université,Sorbonne University (author)
  • Bäckhed, Fredrik,1973Gothenburg University,Göteborgs universitet,Center for Cardiovascular and Metabolic Research (CMR),Wallenberglaboratoriet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberg Laboratory,Institute of Medicine, Department of Molecular and Clinical Medicine,University of Gothenburg(Swepub:gu)xbafre (author)
  • Raes, J.Katholieke Universiteit Leuven,VIB (author)
  • Clement, K.Hôpital de la Salpêtrière,Sorbonne Université,Sorbonne University (author)
  • Sorbonne UniversitéCenter for Cardiovascular and Metabolic Research (CMR) (creator_code:org_t)

Related titles

  • In:Gut: BMJ71:120017-57491468-3288

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By the author/editor
Belda, E.
Voland, L.
Tremaroli, Valen ...
Falony, G.
Adriouch, S.
Assmann, K. E.
show more...
Prifiti, E.
Aron-Wisnewsky, ...
Debedat, J.
Le Roy, T.
Nielsen, T.
Amouyal, C.
Andre, S.
Andreelli, F.
Bluher, M.
Chakaroun, R.
Chilloux, J.
Coelho, L. P.
Dao, M. C.
Das, Promi, 1990
Fellahi, S.
Forslund, S.
Galleron, N.
Hansen, T. H.
Holmes, B.
Ji, Boyang, 1983
Pedersen, H. K.
Le, P.
Le Chatelier, E.
Lewinter, C.
Mannerås Holm, L ...
Marquet, F.
Myridakis, A.
Pelloux, V.
Pons, N.
Quinquis, B.
Rouault, C.
Roume, H.
Salem, J. E.
Sokolovska, N.
Sondertoft, N. B ...
Touch, S.
Vieira-Silva, S.
Galan, P.
Holst, J.
Gotze, J. P.
Kober, L.
Vestergaard, H.
Hansen, T.
Hercberg, S.
Oppert, J. M.
Nielsen, Jens B, ...
Letunic, I.
Dumas, M. E.
Stumvoll, M.
Pedersen, O. B.
Bork, P.
Ehrlich, S. D.
Zucker, J. D.
Bäckhed, Fredrik ...
Raes, J.
Clement, K.
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