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The Majority of Chi...
The Majority of Children Sensitized Before School-Age Develop Allergic Disease Before Adulthood: A Longitudinal Population-Based Study
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- Bunne, Joakim (författare)
- Umeå universitet,Avdelningen för hållbar hälsa
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- Hedman, Linnea, 1979- (författare)
- Umeå universitet,Avdelningen för hållbar hälsa
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- Perzanowski, M. (författare)
- Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, NY, New York, United States
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- Bjerg, A. (författare)
- Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden
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- Winberg, Anna, 1966- (författare)
- Umeå universitet,Pediatrik
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- Andersson, Martin (författare)
- Umeå universitet,Avdelningen för hållbar hälsa
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- Lundbäck, Bo, 1948 (författare)
- Gothenburg University,Göteborgs universitet,Krefting Research Centre,Krefting Research Centre, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden
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- Platts-Mills, T. (författare)
- Division of Allergy & Clinical Immunology, University of Virginia, Va, Charlottesville, United States
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- Rönmark, Eva (författare)
- Umeå universitet,Avdelningen för hållbar hälsa
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(creator_code:org_t)
- Elsevier BV, 2022
- 2022
- Engelska.
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Ingår i: Journal of Allergy and Clinical Immunology: In Practice. - : Elsevier BV. - 2213-2198 .- 2213-2201. ; 10:2
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Abstract
Ämnesord
Stäng
- Background: Allergic sensitization increases the risk of asthma and allergic rhinitis, but the impact of age at onset of sensitization is less studied. Objective: To examine the cumulative incidence of asthma and rhinitis up to age 19 years in relation to age at onset of sensitization to airborne allergens. Method: All children in grade 1 and 2 (median age, 8 years) in 2 municipalities in Northern Sweden were invited to undergo skin prick tests and answer a questionnaire about allergic diseases, and 88% participated. At ages 12 and 19 years, the protocol was repeated, and 1510 individuals participated in all 3 examinations. Specific IgE data were collected in a random sample at age 19 years (n = 770). Onset of sensitization was defined: 8 years or less, 8 to 12 years, 12 to 19 years, and never sensitized. Adjusted Poisson regression was used to calculate risk ratios (RRs). Results: At 19 years, those sensitized at 8 years of age or earlier had the highest risk of asthma (RR, 4.68; 95% CI, 3.15-6.97) and rhinitis (RR, 22.3; 95% CI, 13.3-37.6), and 84% had developed either asthma or rhinitis. The combination of sensitization at age 8 years or earlier and family history of allergic diseases rendered high risks for asthma (RR, 10.6; 95% CI, 6.71-16.7) and rhinitis (RR, 36.3; 95% CI, 18.9-69.7). Individuals sensitized at age 8 years or earlier showed significantly highest level of sensitization, as judged by number of positive skin test results and titers of specific IgE. Conclusions: Most individuals with sensitization at age 8 years or earlier developed asthma or rhinitis before young adulthood. The high level of sensitization in those sensitized early contributes to the high incidence of allergic airway conditions. © 2021 The Authors
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Nyckelord
- Allergic sensitization
- Asthma
- Cohort study
- Longitudinal study
- Rhinitis
- Allergic sensitization
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Bunne, Joakim
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Hedman, Linnea, ...
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Perzanowski, M.
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Bjerg, A.
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Winberg, Anna, 1 ...
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Andersson, Marti ...
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Lundbäck, Bo, 19 ...
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Platts-Mills, T.
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Rönmark, Eva
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Pediatrik
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Lungmedicin och ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Immunologi inom ...
- Artiklar i publikationen
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Journal of Aller ...
- Av lärosätet
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Göteborgs universitet
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Umeå universitet
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Karolinska Institutet