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Is amyloid involved...
Is amyloid involved in acute neuroinflammation? A CSF analysis in encephalitis
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Padovani, A. (author)
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Canale, A. (author)
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Schiavon, L. (author)
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Masciocchi, S. (author)
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Imarisio, A. (author)
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Risi, B. (author)
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Bonzi, G. (author)
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De Giuli, V. (author)
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Di Luca, M. (author)
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- Ashton, Nicholas J. (author)
- Gothenburg University,Göteborgs universitet,Wallenberg Centre for Molecular and Translational Medicine,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Pilotto, A. (author)
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(creator_code:org_t)
- 2022-01-27
- 2022
- English.
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In: Alzheimers & Dementia. - : Wiley. - 1552-5260 .- 1552-5279. ; 18:11, s. 2167-2175
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Abstract
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- Introduction Several investigations have argued for a strong relationship between neuroinflammation and amyloid metabolism but it is still unclear whether inflammation exerts a pro-amyloidogenic effect, amplifies the neurotoxic effect of amyloid, or is protective. Methods Forty-two patients with acute encephalitis (ENC) and 18 controls underwent an extended cerebrospinal fluid (CSF) panel of inflammatory, amyloid (A beta 40, 42, and 38, sAPP-alpha, sAPP-beta), glial, and neuronal biomarkers. Linear and non-linear correlations between CSF biomarkers were evaluated studying conditional independence relationships. Results CSF levels of inflammatory cytokines and neuronal/glial markers were higher in ENC compared to controls, whereas the levels of amyloid-related markers did not differ. Inflammatory markers were not associated with amyloid markers but exhibited a correlation with glial and neuronal markers in conditional independence analysis. Discussion By an extensive CSF biomarkers analysis, this study showed that an acute neuroinflammation state, which is associated with glial activation and neuronal damage, does not influence amyloid homeostasis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- acute inflammation
- amyloid
- glial cells
- neuroinflammation
- tau
- cerebrospinal-fluid biomarkers
- alzheimers-disease
- microglial
- activation
- beta-secretase
- inflammation
- expression
- gamma
- Neurosciences & Neurology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Padovani, A.
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Canale, A.
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Schiavon, L.
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Masciocchi, S.
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Imarisio, A.
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Risi, B.
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show more...
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Bonzi, G.
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De Giuli, V.
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Di Luca, M.
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Ashton, Nicholas ...
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Blennow, Kaj, 19 ...
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Zetterberg, Henr ...
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Pilotto, A.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Alzheimers & Dem ...
- By the university
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University of Gothenburg