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Transcriptomic anal...
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Stratmann, Svea,1989-Uppsala universitet,Experimentell och klinisk onkologi,Linda Holmfeldt
(author)
Transcriptomic analysis reveals proinflammatory signatures associated with acute myeloid leukemia progression
- Article/chapterEnglish2022
Publisher, publication year, extent ...
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2022-01-07
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American Society of Hematology,2022
Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/313882
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https://gup.ub.gu.se/publication/313882URI
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https://doi.org/10.1182/bloodadvances.2021004962DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-191736URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-427202URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:148837264URI
Supplementary language notes
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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De två första författarna delar förstaförfattarskapet
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Numerous studies have been performed over the last decade to exploit the complexity of genomic and transcriptomic lesions driving the initiation of acute myeloid leukemia (AML). These studies have helped improve risk classification and treatment options. Detailed molecular characterization of longitudinal AML samples is sparse, however; meanwhile, relapse and therapy resistance represent the main challenges in AML care. To this end, we performed transcriptome-wide RNA sequencing of longitudinal diagnosis, relapse, and/or primary resistant samples from 47 adult and 23 pediatric AML patients with known mutational background. Gene expression analysis revealed the association of short event-free survival with overexpression of GLI2 and IL1R1, as well as downregulation of ST18. Moreover, CR1 downregulation and DPEP1 upregulation were associated with AML relapse both in adults and children. Finally, machine learning–based and network-based analysis identified overexpressed CD6 and downregulated INSR as highly copredictive genes depicting important relapse-associated characteristics among adult patients with AML. Our findings highlight the importance of a tumor-promoting inflammatory environment in leukemia progression, as indicated by several of the herein identified differentially expressed genes. Together, this knowledge provides the foundation for novel personalized drug targets and has the potential to maximize the benefit of current treatments to improve cure rates in AML. ß 2022 by The American Society of Hematology. Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0), permitting only noncommercial, nonderivative use with attribution. All other rights reserved.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Yones, Sara A.Gothenburg University,Göteborgs universitet,Uppsala universitet,Science for Life Laboratory, SciLifeLab,Beräkningsbiologi och bioinformatik,Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics(Swepub:gu)xabrjo
(author)
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Garbulowski, MateuszUppsala universitet,Beräkningsbiologi och bioinformatik,Science for Life Laboratory, SciLifeLab(Swepub:uu)matga374
(author)
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Sun, JitongUppsala universitet,Experimentell och klinisk onkologi(Swepub:uu)jitsu170
(author)
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Skaftason, A.Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
(author)
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Mayrhofer, Markus,1981-Uppsala universitet,Science for Life Laboratory, SciLifeLab,National Bioinformatics Infrastructure Sweden(Swepub:uu)marra353
(author)
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Norgren, NinaUmeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Department of Molecular Biology, National Bioinformatics Infrastructure Sweden; Science for Life Laboratory, Umeå University, Sweden(Swepub:umu)niakan04
(author)
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Herlin, M. K.Department of Clinical Medicine, Department of Pediatrics and Adolescent Medicine, Aarhus University, Denmark
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Sundström, ChristerUppsala universitet,Klinisk och experimentell patologi(Swepub:uu)chrisund
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Eriksson, Anna,1977-Uppsala universitet,Hematologi(Swepub:uu)anner268
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Höglund, MartinUppsala universitet,Hematologi(Swepub:uu)martinhl
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Palle, Josefine,1964-Uppsala universitet,Barnonkologisk och neurologisk forskning(Swepub:uu)jopal516
(author)
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Abrahamsson, Jonas,1954Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics(Swepub:gu)xabrjo
(author)
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Jahnukainen, K.Children’s Hospital, University of Helsinki, Helsinki University Central Hospital, Helsinki, Finland
(author)
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Munthe-Kaas, M. C.Norwegian Institute of Public Health, Oslo, Norway; Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway
(author)
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Zeller, B.Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway
(author)
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Tamm, K. P.Karolinska Institutet
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Cavelier, LuciaUppsala universitet,Medicinsk genetik och genomik(Swepub:uu)lucicava
(author)
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Komorowski, JanUppsala universitet,Science for Life Laboratory, SciLifeLab,Beräkningsbiologi och bioinformatik,Kollegiet för avancerade studier (SCAS),Institutionen för medicinska vetenskaper,Institutionen för kvinnors och barns hälsa,The Institute of Computer Science, Polish Academy of Sciences, Warsaw, Poland; Washington National Primate Research Center, Seattle, WA, USA; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden; Department of Molecular Biology, National Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Umeå University, Umeå, Sweden; Department of Clinical Medicine and Department of Pediatrics and Adolescent Medicine, Aarhus University, Aarhus, Denmark; Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden; Children's Hospital, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland; Norwegian Institute of Public Health, Oslo, Norway; Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway; Department of Oncology and Pathology, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden(Swepub:uu)jakom133
(author)
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Holmfeldt, LindaUppsala universitet,Experimentell och klinisk onkologi,Linda Holmfeldt(Swepub:uu)linho781
(author)
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Uppsala universitetExperimentell och klinisk onkologi
(creator_code:org_t)
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In:Blood Advances: American Society of Hematology6:1, s. 152-1642473-95292473-9537
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Stratmann, Svea, ...
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Yones, Sara A.
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Garbulowski, Mat ...
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Sun, Jitong
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Skaftason, A.
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Mayrhofer, Marku ...
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Norgren, Nina
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Herlin, M. K.
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Sundström, Chris ...
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Eriksson, Anna, ...
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Höglund, Martin
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Palle, Josefine, ...
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Abrahamsson, Jon ...
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Jahnukainen, K.
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Munthe-Kaas, M. ...
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Zeller, B.
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Tamm, K. P.
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Cavelier, Lucia
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Komorowski, Jan
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Holmfeldt, Linda
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University of Gothenburg
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Umeå University
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