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Type 1 diabetes, co...
Type 1 diabetes, cognitive ability and incidence of cardiovascular disease and death over 60 years of follow-up time in men
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- Dybjer, Elin (författare)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Lund Univ, Sweden
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- Dahl Aslan, Anna K., 1975- (författare)
- Karolinska Institutet,University of Skövde,Högskolan i Skövde,Jönköping University,HHJ, Institutet för gerontologi,HHJ. ARN-J (Aging Research Network - Jönköping),Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden, School of Health Sciences, University of Skövde, Skövde, Sweden,Institutionen för hälsovetenskaper,Forskningsmiljön hälsa, hållbarhet och digitalisering,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden ; Institute of Gerontology, School of Health and Welfare, Jönköping University, Sweden,Välbefinnande vid långvariga hälsoproblem (WeLHP), Wellbeing in Long-term Health Problems,Univ Skovde, Sweden; Karolinska Inst, Sweden; Jonkoping Univ, Sweden
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- Engström, Gunnar (författare)
- Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups,Lund Univ, Sweden
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- Nilsson, Erik D (författare)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Lund Univ, Sweden
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- Nägga, Katarina (författare)
- Linköpings universitet,Linköping University,Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Avdelningen för prevention, rehabilitering och nära vård,Medicinska fakulteten,Region Östergötland, Medicinska och geriatriska akutkliniken,Lund Univ, Sweden
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- Nilsson, Peter M (författare)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Lund Univ, Sweden
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- Hassing, Linda, 1967 (författare)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Centrum för åldrande och hälsa (AgeCap),Psykologiska institutionen,Centre for Ageing and Health (Agecap),Department of Psychology,Department of Psychology, University of Gothenburg, Sweden ; Centre for Ageing and Health, University of Gothenburg, Sweden,Univ Gothenburg, Sweden; Univ Gothenburg, Sweden
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(creator_code:org_t)
- 2022-02-13
- 2022
- Engelska.
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Ingår i: Diabetic Medicine. - : Wiley. - 0742-3071 .- 1464-5491. ; 39:8
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Abstract
Ämnesord
Stäng
- Aims There are few cohorts of type 1 diabetes that follow individuals over more than half a century in terms of health outcomes. The aim of this study was to examine associations between type 1 diabetes, diagnosed before age 18, and long-term morbidity and mortality, and to investigate whether cognitive ability plays a role in long-term morbidity and mortality risk. Methods In a Swedish cohort, 120 men with type 1 diabetes and 469 without type 1 diabetes were followed between 18 and 77 years of age as regards morbidity and mortality outcomes, and impact of cognitive ability at military conscription for the outcomes. In Cox regression analyses and Kaplan-Meier analyses with log-rank tests, associations between diabetes and cognitive ability respectively, and outcomes (mortality, cardiovascular morbidity and diabetes complications) were investigated. Results Men with type 1 diabetes suffered from dramatically higher mortality (HR 4.62, 95% CI: 3.56-5.60), cardiovascular mortality (HR 5.60, 95% CI: 3.27-9.57), and cardiovascular events (HR 3.97, 95% CI: 2.79-5.64) compared to men without diabetes. Higher cognitive ability at military conscription was associated with lower mortality in men without diabetes, but was not associated with any outcome in men with diabetes. Conclusions In this historical cohort study with 60 years of follow-up time and a less effective treatment of diabetes than today, mortality rates and cardiovascular outcomes were high for men with type 1 diabetes. Morbidity or mortality did not differ between those that had low to normal or high cognitive ability among men with type 1 diabetes.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Nyckelord
- cardiovascular events
- cognition
- diabetes mellitus type 1
- epidemiology
- mortality
- prognosis
- coronary-heart-disease
- middle-age
- mortality
- cohort
- association
- mellitus
- iq
- Endocrinology & Metabolism
- cardiovascular events
- Wellbeing in long-term health problems (WeLHP)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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