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  • Arnardottir, SteinunnUppsala universitet,Uppsala University,Uppsala University Hospital,Endokrinologi och mineralmetabolism,Uppsala Univ Hosp, Dept Endocrinol & Diabet, Uppsala, Sweden. (author)

Long-term outcomes of patients with acromegaly: a report from the Swedish Pituitary Register

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • European Society of Endocrinology,2022

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/314232
  • https://gup.ub.gu.se/publication/314232URI
  • https://doi.org/10.1530/EJE-21-0729DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-192366URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:150142626URI
  • https://lup.lub.lu.se/record/4c14ee64-3c9d-4298-8fff-b7f17e6bc682URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-481676URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-187584URI

Supplementary language notes

  • Language:English

Part of subdatabase

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agencies|Swedish Association of Local Authorities and Regions
  • Objective: To describe the treatment and long-term outcomes of patients with acromegaly from all healthcare regions in Sweden. Design and methods: Analysis of prospectively reported data from the Swedish Pituitary Register of 698 patients (51% females) with acromegaly diagnosed from 1991 to 2011. The latest clinical follow-up date was December 2012, while mortality data were collected for 28.5 years until June 2019. Results: The annual incidence was 3.7/million; 71% of patients had a macroadenoma, 18% had visual field defects, and 25% had at least one pituitary hormone deficiency. Eighty-two percent had pituitary surgery, 10% radiotherapy, and 39% medical treatment. At the 5- and 10-year follow-ups, insulin-like growth factor 1 levels were within the reference range in 69 and 78% of patients, respectively. In linear regression, the proportion of patients with biochemical control including adjuvant therapy at 10 years follow-up increased over time by 1.23% per year. The standardized mortality ratio (SMR) (95% CI) for all patients was 1.29 (1.11-1.49). For patients with biochemical control at the latest follow-up, SMR was not increased, neither among patients diagnosed between 1991 and 2000, SMR: 1.06 (0.85-1.33) nor between 2001 and2011, SMR: 0.87 (0.61-1.24). In contrast, non-controlled patients at the latest follow-up from both decades had elevated SMR, 1.90 (1.33-2.72) and 1.98 (1.24-3.14), respectively. Conclusions: The proportion of patients with biochemical control increased over time. Patients with biochemically controlled acromegaly have normal life expectancy, while non-controlled patients still have increased mortality. The high rate of macroadenomas and unchanged age at diagnosis illustrates the need for improvements in the management of patients with acromegaly.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Järås, J.Regional Cancer Center (RCC) Stockholm Gotland, Stockholm, Sweden,Reg Canc Ctr RCC Stockholm Gotland, Stockholm, Sweden. (author)
  • Burman, PiaLund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,Skåne University Hospital,Lund Univ, Skanes Univ Hosp, Dept Endocrinol, Malmö, Sweden.(Swepub:lu)med-bap (author)
  • Berinder, K.Karolinska Institute,Karolinska Institutet,Karolinska University Hospital,Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Endocrinol, Stockholm, Sweden. (author)
  • Dahlqvist, PerUmeå University,Umeå universitet,Avdelningen för medicin,Umeå Univ, Dept Publ Hlth & Clin Med, Umeå, Sweden.(Swepub:umu)perdat96 (author)
  • Erfurth, Eva MarieLund University,Lunds universitet,Endokrin,Forskargrupper vid Lunds universitet,Endocrine,Lund University Research Groups,Skåne University Hospital,Lund Univ, Skanes Univ Hosp, Dept Endocrinol, Malmö, Sweden.(Swepub:lu)med-ee0 (author)
  • Höybye, C.Karolinska Institute,Karolinska Institutet,Karolinska University Hospital,Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Endocrinol, Stockholm, Sweden. (author)
  • Larsson, KarinUppsala universitet,Uppsala University,Uppsala University Hospital,Endokrinologi och mineralmetabolism,Uppsala Univ Hosp, Dept Endocrinol & Diabet, Uppsala, Sweden.(Swepub:lu)med-kil (author)
  • Ragnarsson, Oskar,1971Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Department of Internal Medicine and Clinical Nutrition, Institute of Medicine at Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Department of Endocrinology, Sahlgrenska University Hospital, Gothenburg, Sweden,Univ Gothenburg, Inst Med, Dept Internal Med & Clin Nutr, Sahlgrenska Acad, Gothenburg, Sweden.;Sahlgrens Univ Hosp, Dept Endocrinol, Gothenburg, Sweden.(Swepub:gu)xragos (author)
  • Ekman, BertilLinköpings universitet,Linköping University,Linköping Univ, Dept Endocrinol Linköping, Dept Internal Med Norrköping, Dept Hlth Med & Caring Sci, Linköping, Sweden.,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Endokrinmedicinska kliniken,Region Östergötland, Medicinkliniken ViN(Swepub:liu)berek83 (author)
  • Edén Engström, BrittUppsala universitet,Uppsala University,Uppsala University Hospital,Endokrinologi och mineralmetabolism,Uppsala Univ Hosp, Dept Endocrinol & Diabet, Uppsala, Sweden.(Swepub:uu)brittee (author)
  • Uppsala UniversityUppsala University Hospital (creator_code:org_t)

Related titles

  • In:European Journal of Endocrinology: European Society of Endocrinology186:3, s. 329-3391479-683X0804-4643

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