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Incident cardiovasc...
Incident cardiovascular disease and long-term exposure to source-specific air pollutants in a Swedish cohort
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- Carlsen, Hanne Krage (författare)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine,Occupational and Environmental Medicine, School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
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- Andersson, Eva M., 1968 (författare)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine,Sahlgrenska Academy,Sahlgrenska University Hospital
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- Molnár, Peter, 1967 (författare)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine,Sahlgrenska University Hospital,Sahlgrenska Academy
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- Oudin, Anna (författare)
- Umeå University,Lund University,Lunds universitet,Umeå universitet,Avdelningen för hållbar hälsa,Occupational and Environmental Medicine, Department of Laboratory Medicine, Lund University, Sweden,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine
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- Xu, Yiyi (författare)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine
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- Wichmann, J. (författare)
- University of Pretoria
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- Spanne, M. (författare)
- City of Malmö
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- Stroh, Emilie (författare)
- Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine
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- Engström, Gunnar (författare)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine,Skåne University Hospital
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- Stockfelt, Leo, 1981 (författare)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine,Sahlgrenska Academy,Sahlgrenska University Hospital
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(creator_code:org_t)
- Elsevier BV, 2022
- 2022
- Engelska.
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Ingår i: Environmental Research. - : Elsevier BV. - 0013-9351 .- 1096-0953. ; 209
- Relaterad länk:
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http://dx.doi.org/10...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Background: Air pollution is associated with cardiovascular morbidity and mortality, but its role in the development of congestive heart failure (CHF) and the role of different pollution sources in cardiovascular disease remain uncertain. Methods: Participants were enrolled in the Malmö Diet and Cancer cohort in 1991–1996 with information on lifestyle and clinical indicators of cardiovascular disease. The cohort participants were followed through registers until 2016. Annual total and local source-specific concentrations of particulate matter less than 10 μm and 2.5 μm (PM10 and PM2.5), black carbon (BC), and nitrogen oxides (NOx) from traffic, residential heating, and industry were assigned to each participant's address throughout the study period. Cox proportional hazards models adjusted for possible confounders was used to estimate associations between air pollution 1–5 years prior to outcomes of incident CHF, fatal myocardial infarction (MI), major adverse coronary events (MACE), and ischemic stroke. Results: Air pollution exposure levels (mean annual exposures to PM2.5 of 11 μg/m3 and NOx of 26 μg/m3) within the cohort were moderate in terms of environmental standards. After adjusting for confounders, we observed statistically significant associations between NOx and CHF (hazard ratio [HR] 1.11, 95% confidence interval [CI] 1.01–1.22) and NOx and fatal MI (HR 1.10, 95%CI 1.01–1.20) per interquartile range (IQR) of 9.6 μg/m3. In fully adjusted models, the estimates were similar, but the precision worse. In stratified analyses, the associations were stronger in males, ever-smokers, older participants, and those with baseline carotid artery plaques. Locally emitted and traffic-related air pollutants generally showed positive associations with CHF and fatal MI. There were no associations between air pollution and MACE or stroke. Discussion/conclusion: In an area with low to moderate air pollution exposure, we observed significant associations of long-term residential NOx with increased risk of incident CHF and fatal MI, but not with coronary events and stroke. © 2022
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Nyckelord
- Air pollution
- Cohort study
- Heart failure
- Myocardial infarction
- Source-specific
- Survival analysis
- antihypertensive agent
- antilipemic agent
- black carbon
- hydroxymethylglutaryl coenzyme A reductase inhibitor
- nitrogen oxide
- atmospheric pollution
- cardiovascular disease
- cohort analysis
- disease incidence
- morbidity
- mortality
- particulate matter
- spatiotemporal analysis
- accuracy
- adult
- age distribution
- air pollutant
- Article
- atherosclerosis
- cardiovascular risk factor
- congestive heart failure
- environmental exposure
- exhaust gas
- female
- heart infarction
- heating
- human
- industry
- ischemic stroke
- long term exposure
- major adverse cardiac event
- major clinical study
- male
- middle aged
- particulate matter 10
- particulate matter 2.5
- sex difference
- smoking
- Swedish citizen
- traffic
- Sweden
- Air pollution
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Carlsen, Hanne K ...
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Andersson, Eva M ...
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Molnár, Peter, 1 ...
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Oudin, Anna
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Xu, Yiyi
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Wichmann, J.
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Spanne, M.
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Stroh, Emilie
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Engström, Gunnar
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Stockfelt, Leo, ...
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