Low health-related quality of life in hypoparathyroidism and need for PTH analog

• Objective: Hypoparathyroidism (HypoPT) is a rare endocrine disorder in which insufficient levels of parathyroid hormone (PTH) lead to low serum calcium (S-Ca) levels and muscular cramps. The aim was to study the health-related quality of life (HRQoL) and comorbidities in patients with HypoPT compared with the general population and to estimate the need of treatment with PTH analog. Design: Patients with HypoPT were identified and compared with a population sample. Short Form-36 (SF-36) and EuroQol-5 Dimensions Visual Analogue Scale questionnaires were used. All patients were followed up at the Sahlgrenska University Hospital outpatient clinic. Methods: From the medical records between 2007 and 2020, 203 patients with HypoPT were identified and compared with a population sample (n = 414) from the World Health Organization’s (WHO) MONICA project, Gothenburg, Sweden. Of the 203 patients who met the diagnostic criteria, 164 were alive and 65% answered the HRQoL questionnaires. Results: Patients with HypoPT, 80% postsurgical, and controls had similar age (60 years) and sex distribution (80% women). Patients had lower SF-36 summary component scores for physical (40.0 (interquartile range (IQR): 21) vs 51.2 (IQR: 14.6); P < 0.001) and mental (43.1 (IQR:17.4) vs 56.1(IQR:13.3); P < 0.001) well-being, irrespective of etiology or calcium levels. Individuals with HypoPT had more medications and lower renal function but not higher mortality than controls. Low HRQoL together with low calcium was present in 23% of individuals with HypoPT. Conclusion: HRQoL was markedly lower in patients with HypoPT than in controls and independent of S-Ca levels. Treatment with PTH analog could be considered at least among patients with both low HRQoL and low calcium levels. © 2022 The authors.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

Nyckelord

Calcium

Comorbidity

Hypoparathyroidism

Parathyroid hormone

Quality of life

25 hydroxyvitamin D

calcium ion

creatinine

levothyroxine

thyrotropin

vitamin D

adult

Article

blood biochemistry

blood pressure

blood sampling

body mass

body weight

calcium blood level

calcium metabolism

cardiovascular disease

controlled study

creatinine blood level

depression

female

fracture

gastric bypass surgery

human

hypocalcemia

kidney calcification

kidney failure

kidney function

major clinical study

male

medical record

mental disease

mental health

middle aged

morbidity

mortality

muscle cramp

myalgia

parathyroid hormone blood level

photometry

prevalence

psychological well-being

questionnaire

retrospective study

social interaction

soft tissue calcification

sphygmomanometry

thyrotropin blood level

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)