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Using Distributed L...
Using Distributed Lag Non-Linear Models to Estimate Exposure Lag-Response Associations between Long-Term Air Pollution Exposure and Incidence of Cardiovascular Disease
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- Kriit, Hedi Katre (author)
- Umeå universitet,Avdelningen för hållbar hälsa
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- Andersson, Eva M., 1968 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine,Occupational and Environmental Medicine, Department of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden
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- Carlsen, Hanne Krage (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine,Occupational and Environmental Medicine, Department of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden
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- Andersson, N. (author)
- Karolinska Institutet
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- Stockfelt, Leo, 1981 (author)
- Gothenburg University,Göteborgs universitet,Karolinska Institutet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine
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- Pershagen, G. (author)
- Karolinska Institutet
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- Segersson, D. (author)
- Swedish Meteorological and Hydrological Institute, Norrköping, Sweden
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- Eneroth, K. (author)
- Karolinska Institutet
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- Gidhagen, L. (author)
- Swedish Meteorological and Hydrological Institute, Norrköping, Sweden
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- Spanne, M. (author)
- Environmental Department of the City of Malmö, Malmo, Sweden
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- Molnár, Peter, 1967 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine,Occupational and Environmental Medicine, Department of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden
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- Wennberg, Patrik, 1972- (author)
- Umeå universitet,Allmänmedicin
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- Rosengren, Annika, 1951 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden
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- Rizzuto, D. (author)
- Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Ageing Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden; Stockholm Gerontology Research Center, Stockholm, Sweden
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- Leander, K. (author)
- Karolinska Institutet
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- Yacamán-Méndez, D. (author)
- Karolinska Institutet
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Magnusson, P. K. E. (author)
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- Forsberg, Bertil, professor, 1956- (author)
- Umeå universitet,Avdelningen för hållbar hälsa
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- Stockfelt, Leo, 1981 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine
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- Nilsson Sommar, Johan (author)
- Umeå universitet,Avdelningen för hållbar hälsa
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(creator_code:org_t)
- 2022-02-24
- 2022
- English.
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In: International Journal of Environmental Research and Public Health. - : MDPI AG. - 1661-7827 .- 1660-4601. ; 19:5
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Abstract
Subject headings
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- Long-term air pollution exposure increases the risk for cardiovascular disease, but little is known about the temporal relationships between exposure and health outcomes. This study aims to estimate the exposure-lag response between air pollution exposure and risk for ischemic heart disease (IHD) and stroke incidence by applying distributed lag non-linear models (DLNMs). Annual mean concentrations of particles with aerodynamic diameter less than 2.5 µm (PM2.5 ) and black carbon (BC) were estimated for participants in five Swedish cohorts using dispersion models. Simultaneous estimates of exposure lags 1–10 years using DLNMs were compared with separate year specific (single lag) estimates and estimates for lag 1–5-and 6–10-years using moving average exposure. The DLNM estimated no exposure lag-response between PM2.5 total, BC, and IHD. However, for PM2.5 from local sources, a 20% risk increase per 1 µg/m3 for 1-year lag was estimated. A risk increase for stroke was suggested in relation to lags 2–4-year PM2.5 and BC, and also lags 8–9-years BC. No associations were shown in single lag models. Increased risk estimates for stroke in relation to lag 1–5-and 6–10-years BC moving averages were observed. Estimates generally supported a greater contribution to increased risk from exposure windows closer in time to incident IHD and incident stroke. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Keyword
- Air pollution
- Distributed lag non-linear models
- Ischemic heart disease
- Multicohort
- Particulate matter
- Stroke
- black carbon
- adult
- aged
- Article
- cardiovascular disease
- cardiovascular risk
- cerebrovascular accident
- cohort analysis
- comparative study
- dispersion
- female
- human
- incidence
- long term exposure
- major clinical study
- male
- mathematical model
- particle size
- particulate matter 2.5
- pathophysiology
- Swedish citizen
- particulate matter
- Public health
Publication and Content Type
- ref (subject category)
- art (subject category)
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Kriit, Hedi Katr ...
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Andersson, Eva M ...
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Carlsen, Hanne K ...
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Andersson, N.
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Stockfelt, Leo, ...
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Pershagen, G.
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Segersson, D.
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Eneroth, K.
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Gidhagen, L.
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Spanne, M.
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Molnár, Peter, 1 ...
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Wennberg, Patrik ...
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Rosengren, Annik ...
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Rizzuto, D.
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Leander, K.
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Yacamán-Méndez, ...
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Magnusson, P. K. ...
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Forsberg, Bertil ...
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Nilsson Sommar, ...
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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MEDICAL AND HEAL ...
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and Occupational Hea ...
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University of Gothenburg
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Stockholm University
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Umeå University
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Karolinska Institutet