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PET/CT imaging of s...
PET/CT imaging of spinal inflammation and microcalcification in patients with low back pain: A pilot study on the quantification by artificial intelligence-based segmentation
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- Piri, R. (författare)
- Syddansk Universitet,University of Southern Denmark
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Noddeskou-Fink, A. H. (författare)
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- Gerke, O. (författare)
- Syddansk Universitet,University of Southern Denmark
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Larsson, Måns, 1989 (författare)
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- Edenbrandt, Lars, 1957 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,University of Gothenburg,Sahlgrenska universitetssjukhuset,Sahlgrenska University Hospital
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- Enqvist, Olof, 1981 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Hoilund-Carlsen, P. F. (författare)
- Syddansk Universitet,University of Southern Denmark
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- Stochkendahl, M. J. (författare)
- Syddansk Universitet,University of Southern Denmark
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(creator_code:org_t)
- 2022-04
- 2022
- Engelska.
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Ingår i: Clinical Physiology and Functional Imaging. - : Wiley. - 1475-0961 .- 1475-097X. ; 42:4, s. 225-232
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Abstract
Ämnesord
Stäng
- Background Current imaging modalities are often incapable of identifying nociceptive sources of low back pain (LBP). We aimed to characterize these by means of positron emission tomography/computed tomography (PET/CT) of the lumbar spine region applying tracers F-18-fluorodeoxyglucose (FDG) and F-18-sodium fluoride (NaF) targeting inflammation and active microcalcification, respectively. Methods Using artificial intelligence (AI)-based quantification, we compared PET findings in two sex- and age-matched groups, a case group of seven males and five females, mean age 45 +/- 14 years, with ongoing LBP and a similar control group of 12 pain-free individuals. PET/CT scans were segmented into three distinct volumes of interest (VOIs): lumbar vertebral bodies, facet joints and intervertebral discs. Maximum, mean and total standardized uptake values (SUVmax, SUVmean and SUVtotal) for FDG and NaF uptake in the 3 VOIs were measured and compared between groups. Holm-Bonferroni correction was applied to adjust for multiple testing. Results FDG uptake was slightly higher in most locations of the LBP group including higher SUVmean in the intervertebral discs (0.96 +/- 0.34 vs. 0.69 +/- 0.15). All NaF uptake values were higher in cases, including higher SUVmax in the intervertebral discs (11.63 +/- 3.29 vs. 9.45 +/- 1.32) and facet joints (14.98 +/- 6.55 vs. 10.60 +/- 2.97). Conclusion Observed intergroup differences suggest acute inflammation and microcalcification as possible nociceptive causes of LBP. AI-based quantification of relevant lumbar VOIs in PET/CT scans of LBP patients and controls appears to be feasible. These promising, early findings warrant further investigation and confirmation.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Biomedicinsk laboratorievetenskap/teknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Biomedical Laboratory Science/Technology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Ortopedi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Orthopaedics (hsv//eng)
Nyckelord
- fluorodeoxyglucose
- low back pain
- lumbar vertebrae
- positron emission
- tomography
- sodium fluoride
- facet joint osteoarthritis
- atherosclerotic plaque
- vascular
- calcification
- disc degeneration
- features
- Physiology
- fluorodeoxyglucose
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Piri, R.
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Noddeskou-Fink, ...
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Gerke, O.
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Larsson, Måns, 1 ...
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Edenbrandt, Lars ...
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Enqvist, Olof, 1 ...
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Hoilund-Carlsen, ...
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Stochkendahl, M. ...
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Göteborgs universitet
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Chalmers tekniska högskola