Efficient, mild and completely regioselective synthesis of substituted pyridines

• Addition of Grignard reagents to pyridine N-oxides in THF at low temperature (-78 to -20 °C) and treatment with TFAA provides an efficient general procedure for synthesis of substituted pyridines. The method is compatible with a range of functional groups such as esters, halogens and nitriles.

Ämnesord

NATURVETENSKAP  -- Kemi (hsv//swe)

NATURAL SCIENCES  -- Chemical Sciences (hsv//eng)

Nyckelord

Molecular Structure

Organometallic Compounds

chemistry

Pyridines

chemical synthesis

chemistry

Stereoisomerism

Temperature

Chemistry

Kemi

Molecular Structure

Organometallic Compounds

chemistry

Pyridines

chemical synthesis

Stereoisomerism

Temperature

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ref (ämneskategori)

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